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المؤلفNader, Ahmed M.
المؤلفFoster, David R.
تاريخ الإتاحة2015-11-05T10:11:54Z
تاريخ النشر2014
اسم المنشورJournal of Clinical Pharma
المصدرWiley Online library
الاقتباسNader, A. M. and Foster, D. R. (2014), Suitability of digoxin as a P-glycoprotein probe: Implications of other transporters on sensitivity and specificity. Journal of Clinical Pharma, 54: 3–13.
الرقم المعياري الدولي للكتاب1552-4604
معرّف المصادر الموحدhttp://dx.doi.org/10.1002/jcph.200
معرّف المصادر الموحدhttp://hdl.handle.net/10576/3693
الملخصThe study of transporter-mediated drug–drug interactions (DDI) requires use of appropriate probes to reflect transporter function. Digoxin is often used as a probe in DDI studies involving P-glycoprotein (P-gp) and is recommended by FDA for this purpose, despite several lingering questions regarding suitability of digoxin as P-gp probe. This review aims to critically evaluate use of digoxin as a probe for P-gp-mediated clinical DDI studies, with focus on sensitivity and specificity of digoxin for P-gp. Although previous reviews have evaluated digoxin transport by P-gp, the purpose of the current review is to critically evaluate such literature in light of newly evolving literature suggesting digoxin transport by non-P-gp transporters.
اللغةen
الناشرJohn Wiley & Sons Ltd.
الموضوعdigoxin
P-glycoprotein
drug–drug interaction
transporter
OATP
العنوانSuitability of digoxin as a P-glycoprotein probe: Implications of other transporters on sensitivity and specificity
النوعArticle
رقم العدد1
رقم المجلد54
dc.accessType Abstract Only


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