Suitability of digoxin as a P-glycoprotein probe: Implications of other transporters on sensitivity and specificity
Author | Nader, Ahmed M. |
Author | Foster, David R. |
Available date | 2015-11-05T10:11:54Z |
Publication Date | 2014 |
Publication Name | Journal of Clinical Pharma |
Resource | Wiley Online library |
Citation | Nader, A. M. and Foster, D. R. (2014), Suitability of digoxin as a P-glycoprotein probe: Implications of other transporters on sensitivity and specificity. Journal of Clinical Pharma, 54: 3–13. |
ISSN | 1552-4604 |
Abstract | The study of transporter-mediated drug–drug interactions (DDI) requires use of appropriate probes to reflect transporter function. Digoxin is often used as a probe in DDI studies involving P-glycoprotein (P-gp) and is recommended by FDA for this purpose, despite several lingering questions regarding suitability of digoxin as P-gp probe. This review aims to critically evaluate use of digoxin as a probe for P-gp-mediated clinical DDI studies, with focus on sensitivity and specificity of digoxin for P-gp. Although previous reviews have evaluated digoxin transport by P-gp, the purpose of the current review is to critically evaluate such literature in light of newly evolving literature suggesting digoxin transport by non-P-gp transporters. |
Language | en |
Publisher | John Wiley & Sons Ltd. |
Subject | digoxin P-glycoprotein drug–drug interaction transporter OATP |
Type | Article |
Issue Number | 1 |
Volume Number | 54 |
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Pharmacy Research [1261 items ]