عرض بسيط للتسجيلة

المؤلفRinchai, Darawan
المؤلفDeola, Sara
المؤلفZoppoli, Gabriele
المؤلفKabeer, Basirudeen Syed Ahamed
المؤلفTaleb, Sara
المؤلفPavlovski, Igor
المؤلفMaacha, Selma
المؤلفGentilcore, Giusy
المؤلفToufiq, Mohammed
المؤلفMathew, Lisa
المؤلفLiu, Li
المؤلفVempalli, Fazulur Rehaman
المؤلفMubarak, Ghada
المؤلفLorenz, Stephan
المؤلفSivieri, Irene
المؤلفCirmena, Gabriella
المؤلفDentone, Chiara
المؤلفCuccarolo, Paola
المؤلفGiacobbe, Daniele Roberto
المؤلفBaldi, Federico
المؤلفGarbarino, Alberto
المؤلفCigolini, Benedetta
المؤلفCremonesi, Paolo
المؤلفBedognetti, Michele
المؤلفBallestrero, Alberto
المؤلفBassetti, Matteo
المؤلفHejblum, Boris P.
المؤلفAugustine, Tracy
المؤلفVan Panhuys, Nicholas
المؤلفThiebaut, Rodolphe
المؤلفBranco, Ricardo
المؤلفChew, Tracey
المؤلفShojaei, Maryam
المؤلفShort, Kirsty
المؤلفFeng, Carl G.
المؤلفZughaier, Susu M.
المؤلفDe Maria, Andrea
المؤلفTang, Benjamin
المؤلفHssain, Ali Ait
المؤلفBedognetti, Davide
المؤلفGrivel, Jean Charles
المؤلفChaussabel, Damien
تاريخ الإتاحة2023-01-11T08:36:24Z
تاريخ النشر2022-11-11
اسم المنشورScience Advances
المعرّفhttp://dx.doi.org/10.1126/sciadv.abp9961
الاقتباسRinchai D, Deola S, Zoppoli G, Kabeer BSA, Taleb S, Pavlovski I, Maacha S, Gentilcore G, Toufiq M, Mathew L, Liu L, Vempalli FR, Mubarak G, Lorenz S, Sivieri I, Cirmena G, Dentone C, Cuccarolo P, Giacobbe DR, Baldi F, Garbarino A, Cigolini B, Cremonesi P, Bedognetti M, Ballestrero A, Bassetti M, Hejblum BP, Augustine T, Van Panhuys N, Thiebaut R, Branco R, Chew T, Shojaei M, Short K, Feng CG; PREDICT-19 Consortium; Zughaier SM, De Maria A, Tang B, Ait Hssain A, Bedognetti D, Grivel JC, Chaussabel D. High-temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines. Sci Adv. 2022 Nov 11;8(45):eabp9961. doi: 10.1126/sciadv.abp9961.
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85141670852&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/38314
الملخصKnowledge of the mechanisms underpinning the development of protective immunity conferred by mRNA vaccines is fragmentary. Here, we investigated responses to coronavirus disease 2019 (COVID-19) mRNA vaccination via high–temporal resolution blood transcriptome profiling. The first vaccine dose elicited modest interferon and adaptive immune responses, which peaked on days 2 and 5, respectively. The second vaccine dose, in contrast, elicited sharp day 1 interferon, inflammation, and erythroid cell responses, followed by a day 5 plasmablast response. Both post-first and post-second dose interferon signatures were associated with the subsequent development of antibody responses. Yet, we observed distinct interferon response patterns after each of the doses that may reflect quantitative or qualitative differences in interferon induction. Distinct interferon response phenotypes were also observed in patients with COVID-19 and were associated with severity and differences in duration of intensive care. Together, this study also highlights the benefits of adopting high-frequency sampling protocols in profiling vaccine-elicited immune responses.
اللغةen
الناشرAmerican Association for the Advancement of Science
الموضوعmRNA vaccine
SARS-CoV2
COVID19
Transcriptomics
Immune responses
العنوانHigh–temporal resolution profiling reveals distinct immune trajectories following the first and second doses of COVID-19 mRNA vaccines
النوعArticle
رقم العدد45
رقم المجلد8
ESSN2375-2548
dc.accessType Open Access


الملفات في هذه التسجيلة

Thumbnail

هذه التسجيلة تظهر في المجموعات التالية

عرض بسيط للتسجيلة