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AuthorParray, Aijaz
AuthorMir, Fayaz A.
AuthorDoudin, Asmma
AuthorIskandarani, Ahmad
AuthorDanjuma, Ibn M.
AuthorKuni, Rahim A.
AuthorAbdelmajid, Alaaedin
AuthorAbdelhafez, Ibrahim
AuthorArif, Rida
AuthorMulhim, Mohammad
AuthorAbukhattab, Mohammad
AuthorDar, Shoukat R.
AuthorMoustafa, Ala-Eddin A.
AuthorElkord, Eyad
AuthorAl Khal, Abdul L.
AuthorElzouki, Abdel-Naser
AuthorCyprian, Farhan
Available date2023-01-23T05:30:13Z
Publication Date2021
Publication NameVaccines
ResourceScopus
URIhttp://dx.doi.org/10.3390/vaccines9101056
URIhttp://hdl.handle.net/10576/38687
AbstractThere is a lack of predictive markers for early and rapid identification of disease progression in COVID-19 patients. Our study aims at identifying microRNAs (miRNAs)/small nucleolar RNAs (snoRNAs) as potential biomarkers of COVID-19 severity. Using differential expression analysis of microarray data (n = 29), we identified hsa-miR-1246, ACA40, hsa-miR-4532, hsa-miR-145-5p, and ACA18 as the top five differentially expressed transcripts in severe versus asymptomatic, and ACA40, hsa-miR-3609, ENSG00000212378 (SNORD78), hsa-miR-1231, hsa-miR-885-3p as the most significant five in severe versus mild cases. Moreover, we found that white blood cell (WBC) count, absolute neutrophil count (ANC), neutrophil (%), lymphocyte (%), red blood cell (RBC) count, hemoglobin, hematocrit, D-Dimer, and albumin are significantly correlated with the identified differentially expressed miRNAs and snoRNAs. We report a unique miRNA and snoRNA profile that is associated with a higher risk of severity in a cohort of SARS-CoV-2 infected patients. Altogether, we present a differential expression analysis of COVID-19-associated microRNA (miRNA)/small nucleolar RNA (snoRNA) signature, highlighting their importance in SARS-CoV-2 infection.
SponsorQatar University QUST-1-CMED-2021-2 (FC). We gratefully acknowledge Hashim Alhussain for providing support in the BSL-3 laboratory at Qatar University.
Languageen
PublisherMDPI
SubjectAnalogs
Chalcone
Colorectal cancer
Epithelial-mesenchymal transition (EMT)
KRAS mutation
Metastasis
TitleSnornas and mirnas networks underlying covid-19 disease severity
TypeArticle
Issue Number10
Volume Number9
dc.accessType Open Access


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