Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
Author | Dania, Kattan |
Author | Barsa, Chloe |
Author | Mekhijian, Sarin |
Author | Shakkour, Zaynab |
Author | Jammoul, Maya |
Author | Doumit, Mark |
Author | Zabala, Maria Camila Pareja |
Author | Darwiche, Nadine |
Author | Eid, Ali H. |
Author | Mechref, Yehia |
Author | Wang, Kevin K. |
Author | de Rivero Vaccari, Juan Pablo |
Author | Munoz Pareja, Jennifer C. |
Author | Kobeissy, Firas |
Available date | 2023-01-30T07:10:26Z |
Publication Date | 2023-01-31 |
Publication Name | Neuroscience & Biobehavioral Reviews |
Identifier | http://dx.doi.org/10.1016/j.neubiorev.2022.104969 |
Citation | Kattan D, Barsa C, Mekhijian S, et al. Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview. Neurosci Biobehav Rev. 2023;144:104969. doi:10.1016/j.neubiorev.2022.104969 |
ISSN | 01497634 |
Abstract | Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an increasing need to better understand the mechanisms of TBI. Recently, the roles of inflammasomes have been highlighted as both potential therapeutic targets and diagnostic markers in different neurodegenerative disorders. Indeed, inflammasome activation plays a pivotal function in the central nervous system (CNS) response to many neurological conditions, as well as to several neurodegenerative disorders, specifically, TBI. This comprehensive review summarizes and critically discusses the mechanisms that govern the activation and assembly of inflammasome complexes and the major methods used to study inflammasome activation in TBI and its implication for other neurodegenerative disorders. Also, we will review how inflammasome activation is critical in CNS homeostasis and pathogenesis, and how it can impact chronic TBI sequalae and increase the risk of developing neurodegenerative diseases. Additionally, we discuss the recent updates on inflammasome-related biomarkers and the potential to utilize inflammasomes as putative therapeutic targets that hold the potential to better diagnose and treat subjects with TBI. |
Sponsor | This work is partially supported by the grant "UL1TR002736, Miami Clinical, and Translational Science Institute, from the National Center for Advancing Translational Sciences and the National Institute on Minority Health and Health Disparities" (PI: J C. Munoz Pareja). Additionally, this work was also supported by grants from NIH for (PI: Yehia Mechref) (1R01GM112490-09, 1U01CA225753-05, and 1R01GM130091-04) and for (PI: JPdRV) (1R01NS113969-01, 1RF1NS125578-01). |
Language | en |
Publisher | Elsevier |
Subject | Inflammasomes Traumatic brain injury Neurodegenerative diseases Caspase-1 Pyroptosis Biomarkers Therapeutic targets NLPR1 |
Type | Article |
Volume Number | 144 |
Check access options
Files in this item
This item appears in the following Collection(s)
-
Medicine Research [1470 items ]