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AuthorBani-Ahmad, Mohammad A.
AuthorMustafa, Ayman G.
AuthorBani Ahmad, Abdelraheem A.
AuthorAlkhazali, Islam E.
AuthorRahim, Ahmad A.
Available date2023-03-28T10:16:40Z
Publication Date2022-09-28
Publication NameJournal of Toxicology
Identifierhttp://dx.doi.org/10.1155/2022/3996051
CitationBani-Ahmad, M. A., Mustafa, A. G., Bani Ahmad, A. A., Alkhazali, I. E., & Rahim, A. A. (2022). Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes. Journal of Toxicology, 2022.
ISSN1687-8191
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85139792160&origin=inward
URIhttp://hdl.handle.net/10576/41387
AbstractAway from hemorheological properties, the effect of heroin addiction on erythrocytes is poorly investigated. This study aimed to investigate the oxidative impacts of heroin administration on erythrocytes. Study subjects included chronic intravenous heroin addicts and control subjects. Hematological analysis and redox parameters were measured, including serum concentration of methemoglobin ([MethHb]), serum glutathione peroxidase-1 ([GPX-1]), serum glutathione peroxidase (GPX) activity, erythrocytic protein carbonyl content, and oxidized to reduced glutathione (GSSG/GSH) ratio. Hematological analysis revealed that addicts had a significantly higher red cell distribution width, consistent with the mild anisocytosis and poikilocytosis of erythrocytes. As compared to control subjects, significantly higher levels of serum [Met-Hb], [GPX-1], and GPX activity (p<0.001) were reported among addicted subjects. A significant association between [MetHb] and GPX activity was observed with r = 0.764 (p<0.001). Furthermore, significantly higher erythrocytic protein carbonyl contents and GSSG/GSH ratio were evident among heroin addicts (p<0.005) that were significantly associated with r = 0.429 (p=0.01). Results demonstrate preliminary evidence that heroin addiction is implicated in impaired redox status of erythrocytes. Considering the pharmacokinetics of heroin, erythrocytic antioxidant mechanisms, and turnover rate, further investigation is required to evaluate the extent and clinical outcomes, especially upon over-dose administration.
Languageen
PublisherHindawi
SubjectHeroin
edox status
erythrocytes
TitleEvidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes
TypeArticle
Volume Number2022
ESSN1687-8205
dc.accessType Open Access


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