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Assay-agnostic spatial profiling detects tumor microenvironment signatures: new diagnostic insights for triple-negative breast cancer
( John Wiley and Sons Ltd , 2023 , Article)The role of the tumor microenvironment (TME) in immuno-oncology has driven demand for technologies that deliver in situ, or spatial, molecular information. Compartmentalized heterogeneity that traditional methods miss is ... -
Clozapine prescribing practice and trends in Qatar: First national observational study
( John Wiley and Sons Ltd , 2022 , Article)Background: Clozapine is the gold standard in the management of treatment-resistant schizophrenia. Despite its clinically proven efficacy clozapine utilization is variable globally and published evidence is suggestive of ... -
Comment on a review of methods to assess publication and other reporting biases in meta-analysis
( John Wiley and Sons Ltd , 2022 , Article)We read with interest the well-written review on the assessment of publication and other reporting biases in meta-analysis by Page et al.1 in which both funnel plots and tests for its asymmetry were described. The decision ... -
Sex-based differences in severity and mortality in COVID-19
( John Wiley and Sons Ltd , 2021 , Article Review)The current coronavirus disease (COVID-19) pandemic caused by novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a male bias in severity and mortality. This is consistent with previous coronavirus ... -
Testosterone and Covid-19: An update
( John Wiley and Sons Ltd , 2023 , Article Review)There is overwhelming evidence to suggest that male gender is at a higher risk of developing more severe Covid-19 disease and thus having poorer clinical outcomes. However, the relationship between testosterone (T) and ... -
The purification and identification of human blood serum proteins with affinity to the antitumor active RL2 lactaptin using magnetic microparticles
( John Wiley and Sons Ltd , 2019 , Article)The cytopoxic effect of RL2 lactaptin (the recombinant analog of proteolytic fragment of human kappa‐casein) toward tumor cells in vitro and in vivo presents it as a novel promising antitumor drug. The binding of any drug ...