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Angry scientists, angry analysts and angry novelists
( Springer Nature , 2023 , Other)To the Editor: Professor Bonora has written a critique looking back at his career in diabetes research since the 1970s and we reflect on his critique by also looking back at our careers in clinical endocrinology (Professor ... -
Antibiotic prescriptions for oral diseases in India: evidence from national prescription data
( Springer Nature , 2023 , Article)Introduction: The key objective of this research was to describe the prescription rate of various antibiotics for dental problems in India and to study the relevance of the prescriptions by analysing antibiotic types ... -
Association of polypharmacy with incidence of CKD: a retrospective cohort study: a letter to the Editor
( Springer Nature , 2023 , Other)Kimura et al.’s recently published report on a retrospective examination of the Fukushima chronic kidney disease (CKD) patient cohort provides an interesting perspective on this rising therapeutic morbidity [1]. The study ... -
Effect of very long-term storage and multiple freeze and thaw cycles on 11-dehydro-thromboxane-B(2) and 8-iso-prostaglandin F(2α,) levels in human urine samples by validated enzyme immunoassays
( Springer Nature , 2024 , Article)Biological samples are often frozen and stored for years and/or thawed multiple times, thus assessing their stability on long-term storage and repeated freeze–thaw cycles is crucial. The study aims were to assess:—the ... -
Exploring use of unsupervised clustering to associate signaling profiles of GPCR ligands to clinical response.
( Springer Nature , 2019 , Article)Signaling diversity of G protein-coupled (GPCR) ligands provides novel opportunities to develop more effective, better-tolerated therapeutics. Taking advantage of these opportunities requires identifying which effectors ... -
Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity
( Springer Nature , 2020 , Article)Synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA) are characterized by pathological accumulation of α-synuclein (α-syn). Amongst the various approaches ... -
High-Risk Human Papillomaviruses (HPV) and Epstein - Barr virus (EBV) are Commonly Present in Rectal Cancer
( Springer Nature , 2020 , Conference Paper)Background: Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV) are well-established oncoviruses that can be co-present and cooperate in the initiation and/or progression of various human cancers. We recently reported ... -
Identification of potential transcription factors that enhance human iPSC generation
( Springer Nature , 2020 , Article)Although many factors have been identified and used to enhance the iPSC reprogramming process, its efficiency remains quite low. In addition, reprogramming efficacy has been evidenced to be affected by disease mutations ... -
The impact of enteric coating of aspirin on aspirin responsiveness in patients with suspected or newly diagnosed ischemic stroke: prospective cohort study: results from the (ECASIS) study
( Springer Nature , 2022 , Article)Background and purpose: Uncertainty remains regarding the impact of enteric-coated aspirin (EC-ASA) on secondary prevention of ischemic stroke compared to plain aspirin (P-ASA). Hence, this study was designed to investigate ... -
Inflammatory protein signatures in individuals with obesity and metabolic syndrome
( Springer Nature , 2023 , Article)There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, ... -
Influence of lack of blinding on the estimation of medication-related harms: a retrospective cohort study of randomized controlled trials.
( Springer Nature , 2024 , Article)Empirical evidence suggests that lack of blinding may be associated with biased estimates of treatment benefit in randomized controlled trials, but the influence on medication-related harms is not well-recognized. We aimed ... -
An integrated multi-omic approach demonstrates distinct molecular signatures between human obesity with and without metabolic complications: a case–control study
( Springer Nature , 2023 , Article)Objectives: To examine the hypothesis that obesity complicated by the metabolic syndrome, compared to uncomplicated obesity, has distinct molecular signatures and metabolic pathways. Methods: We analyzed a cohort of 39 ... -
Intersection between genes controlling vascularization and angiogenesis in renal cell carcinomas
( Springer Nature , 2018 , Article)To show that application of the systemic analysis may significantly improve comparison of different datasets. Different genes and proteins may converge on the same functional outputs. A comparison of 2 datasets by only ... -
An investigation into the avoidability of drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome
( Springer Nature , 2021 , Article)Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rising morbidity amongst hospitalized patients. Whilst clinical protocols for the management of individual DRESS cases have been well established, ... -
Machine learning and discriminant function analysis in the formulation of generic models for sex prediction using patella measurements
( Springer Nature , 2022 , Article)Sex prediction from bone measurements that display sexual dimorphism is one of the most important aspects of forensic anthropology. Some bones like the skull and pelvis display distinct morphological traits that are based ... -
Molecular characterization of cancers with NTRK gene fusions
( Springer Nature , 2019 , Article)Targeted inhibitors of neurotropic tyrosine kinases are highly effective in selected patients with gene fusions involving NTRK1, NTRK2, or NTRK3. These fusions are consistently detected in rare cancer types (e.g., secretory ... -
Molecular Profiling of Clear Cell Carcinoma of the Breast Reveals Novel Targetable Biomarkers
( Springer Nature , 2020 , Conference Paper)Background: Although clear cell morphology may be seen in various subtypes of breast cancer, a pure variant of clear cell carcinoma (usually glycogen-rich) is a very rare primary breast malignancy. It is characterized by ... -
The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.
( Springer Nature , 2020 , Article)Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, ... -
NDDNet: a deep learning model for predicting neurodegenerative diseases from gait pattern
( Springer Nature , 2023 , Article)Neurodegenerative diseases damage neuromuscular tissues and deteriorate motor neurons which affects the motor capacity of the patient. Particularly the walking gait is greatly influenced by the deterioration process. Early ... -
Neurological Complications of Local Anesthesia in Dentistry: A Review.
( Springer Nature , 2023 , Article)Local anesthesia is a technique that temporarily desensitizes a specific body area, typically for a surgical procedure, dental work, or pain management. It is described as a sensation loss in a specific area of the body ...