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    Inflammatory protein signatures in individuals with obesity and metabolic syndrome

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    s41598-023-49643-8.pdf (3.546Mb)
    Date
    2023-12-13
    Author
    Mir, Fayaz Ahmad
    Abdesselem, Houari B.
    Cyprian, Farhan
    Iskandarani, Ahmad
    Doudin, Asmma
    Samra, Tareq A.
    Alkasem, Meis
    Abdalhakam, Ibrahem
    Taheri, Shahrad
    Abou-Samra, Abdul Badi
    ...show more authors ...show less authors
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    Abstract
    There is variability in the metabolic health status among individuals presenting with obesity; some may be metabolically healthy, while others may have developed the metabolic syndrome, a cluster including insulin resistance, hypertension, dyslipidemia, and increased risk of cardiovascular disease and type 2 diabetes. The mechanisms contributing to this metabolic heterogeneity are not fully understood. To address this question, plasma samples from 48 individuals with BMI ≥ 35 kg/m2 were examined (27 with and 21 without metabolic syndrome). Fasting plasma samples were subjected to Olink proteomics analysis for 184 cardiometabolic and inflammation-enriched proteins. Data analysis showed a clear differentiation between the two groups with distinct plasma protein expression profiles. Twenty-four proteins were differentially expressed (DEPs) between the two groups. Pathways related to immune cell migration, leukocyte chemotaxis, chemokine signaling, mucosal inflammatory response, tissue repair and remodeling were enriched in the group with metabolic syndrome. Functional analysis of DEPs revealed upregulation of 15 immunological pathways. The study identifies some of the pathways that are altered and reflect metabolic health in individuals with obesity. This provides valuable insights into some of the underlying mechanisms and can lead to identification of therapeutic targets to improve metabolic health in individuals with obesity.
    URI
    https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85179743116&origin=inward
    DOI/handle
    http://dx.doi.org/10.1038/s41598-023-49643-8
    http://hdl.handle.net/10576/53063
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    • Medicine Research [‎1819‎ items ]

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