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Letter to the editor: From Min Gong et al: "Risk for infections during treatment with denosumab for osteoporosis: a systematic review and meta-analysis"
(
Endocrine Society
, 2020 , Other)
To the editor: We read with great interest the systematic review by Diker-Cohen et al (1) about the risk of infection under the treatment of denosumab for osteoporosis. This is a well-conducted systematic review that ...
Reactive oxygen species: Modulators of phenotypic switch of vascular smooth muscle cells
(
MDPI
, 2020 , Article Review)
Reactive oxygen species (ROS) are natural byproducts of oxygen metabolism in the cell. At physiological levels, they play a vital role in cell signaling. However, high ROS levels cause oxidative stress, which is implicated ...
Cardiac autonomic neuropathy: A progressive consequence of chronic low-grade inflammation in type 2 diabetes and related metabolic disorders
(
MDPI
, 2020 , Article Review)
Cardiac autonomic neuropathy (CAN) is one of the earliest complications of type 2 diabetes (T2D), presenting a silent cause of cardiovascular morbidity and mortality. Recent research relates the pathogenesis of cardiovascular ...
Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
(
Frontiers Media
, 2020 , Article)
The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for ...
Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals
(
MDPI
, 2020 , Article)
Abstract: To support the deployment of serology assays for population screening during the
COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i® (target: spike [S] ...
Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2020 , Article)
Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions ...
Polypharmacy and drug interactions amongst cirrhotic patients discharged from a tertiary center: Results from a national quality improvement audit
(
Elsevier
, 2020 , Article)
Background and Study AimsAuditing of polypharmacy is particularly essential in patients with cirrhosis because of the crucial role of liver in drug metabolism. The aim of this study was to audit the drug prescribed in this ...
QTc evaluation in COVID-19 patients treated with chloroquine/hydroxychloroquine: A letter to the editor
(
Wiley-Blackwell
, 2020 , Other)
We read with interest Monzani et al's report1 on QT pro-longation in COVID-19 patients on treatment with chloro-quine/hydroxychloroquine (CQ/HCQ). Her report highlights the therapeutic morbidities ...
An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
(
Wolters Kluwer Health
, 2020 , Article)
An adverse drug reactions avoidability tool called the Liverpool ADR avoidability assessment tool (LAAT) was recently developed (for research purposes), and subsequently validated with mixed interrater reliability (IRR). ...
Myxedema psychosis: A protocol for a systematic review and a pooled analysis
(
Wolters Kluwer Health
, 2020 , Article)
Background: Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability ...