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Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
(
Frontiers Media
, 2020 , Article)
The global pandemic of COVID-19 disease caused by infection with the SARS-CoV-2 coronavirus, has produced an urgent requirement and search for improved treatments while effective vaccines are developed. A strategy for ...
Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals
(
MDPI
, 2020 , Article)
Abstract: To support the deployment of serology assays for population screening during the
COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i® (target: spike [S] ...
Visfatin: A Possible Role in Cardiovasculo-Metabolic Disorders
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2020 , Article)
Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is an adipocytokine with several intriguing properties. It was first identified as pre-B-cell colony-enhancing factor but turned out to possess enzymatic functions ...
Polypharmacy and drug interactions amongst cirrhotic patients discharged from a tertiary center: Results from a national quality improvement audit
(
Elsevier
, 2020 , Article)
Background and Study AimsAuditing of polypharmacy is particularly essential in patients with cirrhosis because of the crucial role of liver in drug metabolism. The aim of this study was to audit the drug prescribed in this ...
An investigation into the avoidability of adverse drug reactions using the LAAT and modified Hallas tools
(
Wolters Kluwer Health
, 2020 , Article)
An adverse drug reactions avoidability tool called the Liverpool ADR avoidability assessment tool (LAAT) was recently developed (for research purposes), and subsequently validated with mixed interrater reliability (IRR). ...
Myxedema psychosis: A protocol for a systematic review and a pooled analysis
(
Wolters Kluwer Health
, 2020 , Article)
Background: Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability ...
An investigation into the impact of enteric coated of aspirin in patients with newly diagnosed ischemic stroke (ECASIS)
(
Wolters Kluwer Health
, 2020 , Article)
Introduction:Uncertainty remains regarding the impact of enteric-coated (EC) aspirin as it relates to the reduction of cardiovascular risk. We hypothesize that EC formulation based on a previous report may blunt aspirin ...
An unusual case of modified Lemierre’s syndrome caused by staphylococcus aureus cellulitis
(
International Scientific Literature Inc.
, 2020 , Article)
Patient: Male, 31-year-old
Final Diagnosis: Lemierre’s Disease
Symptoms: Conjunctival injection • eye pain and redness • fever • nasal swelling • periorbital oedema • ptosis • vesicular lesions nose
Medication: — Clinical ...
Fetal holoprosencephaly
(
Jaypee Brothers Medical Publishers (P) Ltd
, 2020 , Article)
Holoprosencephaly is a birth defect that leads to an abnormal brain development where the brain fails to divide into two hemispheres. Possible causes are environmental or genetic factors. Holoprosencephaly can include ...
Pregnancy and Neonatal Outcomes in SARS-CoV-2 Infection: A Systematic Review
(
Hindawi
, 2020 , Article)
With the emergence of SARS-CoV-2 and its rapid spread, concerns regarding its effects on pregnancy outcomes have been growing. We reviewed 245 pregnancies complicated by maternal SARS-CoV-2 infection across 48 studies ...