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Chemical Analysis and Investigation of Biological Effects of Salvia officinalis Essential Oils at Three Phenological Stages
(
MDPI
, 2022 , Article)
Salvia officinalis is a medicinal plant used to treat some diseases, including microbial infections and diabetes. Different studies showed the biological and pharmacological properties of this species. The aim of this study ...
Nanoparticles: Attractive tools to treat colorectal cancer
(
Elsevier
, 2022 , Article)
Colorectal Cancer (CRC) is one of the leading causes of cancer-related deaths worldwide. Despite the notable advances achieved over the last few decades, CRC remains a hard-to-treat deadly disease in many patients. This ...
Dexamethasone Promotes a Stem-Like Phenotype in Human Melanoma Cells via Tryptophan 2,3 Dioxygenase
(
Frontiers Media
, 2022 , Article)
In addition to its well-established immunosuppressive actions, tryptophan 2,3-dioxygenase (TDO) appears to elicit direct effects on tumor cell function. Although TDO has been associated with cancer stemness, its involvement ...
Does the Sex of the Firstborn Child Affect the Breast Cancer Risk and Survival: A Systematic Review and Meta-analysis of Over 1 Million Cases
(
Galenos Yayinevi
, 2022 , Article)
Background: Reports on the risk and prognosis of breast cancer in relation to the sex of a child have been conflicting. Since medical sciences play an important role in informing sociocultural understandings of health and ...
A Delphi consensus study introducing a Problem And attRibutes‐bAsed DIabetes self‐manaGeMent (PARADIGM) intervention for patients with type 2 diabetes
(
Elsevier
, 2022 , Article)
AimEncouraging patients to improve their self-management behavior based on a strict definition of the intervention is important for a standardized delivery but, until recently, there was no consensus on the core attributes ...
Assessing the consistency of iPSC and animal models in cystic fibrosis modelling: A metaanalysis
(
Public Library of Science
, 2022 , Article)
Introduction Cystic fibrosis (CF) is a hereditary autosomal recessive disorder caused by a range of mutations in the CF Transmembrane Conductance Regulator (CFTR) gene. This gene encodes the CFTR protein, which acts as a ...
PTRH2 is Necessary for Purkinje Cell Differentiation and Survival and its Loss Recapitulates Progressive Cerebellar Atrophy and Ataxia Seen in IMNEPD Patients
(
Springer
, 2022 , Article)
Homozygous variants in the peptidyl-tRNA hydrolase 2 gene (PTRH2) cause infantile-onset multisystem neurologic, endocrine, and pancreatic disease. The objective is to delineate the mechanisms underlying the core cerebellar ...
Duration of COVID-19 mRNA Vaccine Effectiveness against Severe Disease
(
MDPI
, 2022 , Article)
Waning immunity following administration of mRNA-based COVID-19 vaccines remains a concern for many health systems. We undertook a study to determine if recent reports of waning for severe disease could have been attributed ...
Data reproducibility issues and their potential impact on conclusions from evidence syntheses of randomized controlled trials in sleep medicine
(
Elsevier
, 2022 , Article)
In this study, we examined the data reproducibility issues in systematic reviews in sleep medicine. We searched for systematic reviews of randomized controlled trials published in sleep medicine journals. The metadata in ...
Should studies with no events in both arms be excluded in evidence synthesis?
(
Elsevier
, 2022 , Article)
ObjectivesIn safety assessment, studies with no events are a frequent occurrence when conducting meta-analyses. The current approach in meta-analysis is to exclude double-zero studies from the synthesis. In this study, we ...