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SPERM FACTORS AND EGG ACTIVATION The structure and function relationship of sperm PLCZ1
(
BioScientifica
, 2022 , Article Review)
In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection ...
Deregulation of cell growth and apoptosis in UV-induced melanomagenesis
(
Frontiers in Bioscience
, 2020 , Article Review)
We have previously characterized the role of p16/Rb in coordinating the early events in UVB-irradiated skin. As an extension to this work, normal melanocytes and mutant p16-inducible melanoma cell models were employed to ...
KYNU, a novel potential target that underpins CD44-promoted breast tumour cell invasion
(
Blackwell Publishing Inc.
, 2021 , Article Review)
Using a validated tetracycline-off-inducible CD44 expression system in mouse model, we have previously demonstrated that the hyaluronan (HA) receptor CD44 promotes breast cancer (BC) metastasis to the liver. To unravel the ...
The power of phytochemicals combination in cancer chemoprevention
(
Ivyspring International Publisher
, 2020 , Article Review)
Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ...
Antibody-Dependent Enhancement (ADE) and the role of complement system in disease pathogenesis
(
Elsevier Ltd
, 2022 , Article Review)
Antibody-dependent enhancement (ADE) has been associated with severe disease outcomes in several viral infections, including respiratory infections. In vitro and in vivo studies showed that antibody-response to SARS-CoV ...
The Association between Early Opioids Prescribing and the Length of Disability in Acute Lower Back Pain: A Systematic Review and Narrative Synthesis
(
MDPI
, 2022 , Article Review)
Background: There is conflicting evidence with respect to whether early opioid prescribing (EOP) within the first two weeks of acute Low Back Pain (LBP) onset is associated with the length of disability (LOD). The aim of ...
Metabolic aspects of surgical subcutaneous fat removal: an umbrella review and implications for future research.
(
Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
, 2022 , Article Review)
Although obesity is a preventable disease, maintaining a normal body weight can be very challenging and difficult, which has led to a significant increase in the demand for surgical subcutaneous fat removal (SSFR) to improve ...
Metabolic changes after surgical fat removal: A dose–response meta-analysis
(
Elsevier
, 2023 , Article Review)
BackgroundBariatric surgery averts obesity-induced insulin resistance and the metabolic syndrome. By contrast, surgical fat removal is considered merely an esthetic endeavor. The aim of this article was to establish whether ...
Metabolic changes after nonsurgical fat removal: A dose response meta-analysis
(
Elsevier
, 2023 , Article Review)
BackgroundObesity-induced insulin resistance leads to the metabolic syndrome. Both bariatric surgery and surgical fat removal have been shown to improve metabolic health, but the metabolic benefits of nonsurgical fat removal ...
Evolution of gastroesophageal reflux disease symptoms after bariatric surgery: A dose–response meta-analysis
(
Elsevier
, 2022 , Article Review)
BackgroundObesity is associated with increased prevalence of gastroesophageal reflux disease, with recent reports suggesting improvement in gastroesophageal reflux disease symptoms and weight loss following bariatric ...