College of Medicine: Recent submissions
Now showing items 761-780 of 1514
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Direct oral anticoagulants are effective and safe in the treatment of venous thromboembolism and atrial fibrillation in morbidly obese patients
( Springer , 2020 , Article)There has always been unresolved uncertainty regarding the therapeutic utility of direct oral anticoagulants (DOACs) in morbidly obese patients (BMI > 40 kg/m2 or weight > 120 kg) with clinical indications for anticoagulant's ... -
Effectiveness of Integrated Diabetes Care Interventions Involving Diabetes Specialists Working in Primary and Community Care Settings: A Systematic Review and Meta-Analysis
( Ubiquity Press , 2022 , Article)Introduction: Evidence that integrated diabetes care interventions can substantially improve clinical outcomes is mixed. However, previous systematic reviews have not focussed on clinical effectiveness where the endocrinologist ... -
Comparative effectiveness and safety of direct oral anticoagulants compared to warfarin in morbidly obese patients with acute venous thromboembolism: systematic review and a meta-analysis
( Springer , 2021 , Article)Direct oral anticoagulant (DOAC) agents are becoming the anticoagulation strategy of choice. However, their use in the treatment of acute venous thromboembolism (VTE) in morbidly obese patients (bodyweight of > 120 kg or ... -
Structures, processes and outcomes of objective structured clinical examinations in dental education during the COVID-19 pandemic: A scoping review
( Wiley-Blackwell , 2022 , Article)Introduction: Objective structured clinical examinations (OSCEs) are an essential examination tool within undergraduate dental education. Fear of spread of the COVID-19 virus led to dental institutions exploring alternative ... -
Evidence on the Heroin-Mediated Impairment of the Oxidative Status of Erythrocytes
( Hindawi , 2022 , Article)Away from hemorheological properties, the effect of heroin addiction on erythrocytes is poorly investigated. This study aimed to investigate the oxidative impacts of heroin administration on erythrocytes. Study subjects ... -
Screening and diagnostic testing protocols for HIV and Syphilis infections in health care setting in Qatar: Evaluation and recommendations
( Public Library of Science , 2023 , Article)Background HIV and Syphilis are common STIs, which have become a concern and burden on healthcare systems, as many infections go untreated and lead to potentially serious complications. HIV is usually diagnosed with Western ... -
Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study
( Frontiers Media , 2023 , Article)Introduction: The BNT162b2 mRNA-based vaccine has shown high efficacy in preventing COVID-19 infection but there are limited data on the types and persistence of the humoral and T cell responses to such a vaccine. Methods: ... -
Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm
( MDPI , 2023 , Article)Mammalian oocyte activation is initiated by intracellular calcium (Ca2+) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation ... -
Epac as a tractable therapeutic target
( Elsevier , 2023 , Article)In 1957, cyclic adenosine monophosphate (cAMP) was identified as the first secondary messenger, and the first signaling cascade discovered was the cAMP-protein kinase A (PKA) pathway. Since then, cAMP has received increasing ... -
Dicarbonyl stress, protein glycation and the unfolded protein response
( Springer , 2021 , Article Review)The reactive dicarbonyl metabolite, methylglyoxal (MG), is increased in obesity and diabetes and is implicated in the development of insulin resistance, type 2 diabetes mellitus and vascular complications of diabetes. ... -
Efficiency and productivity of health systems in prevention and control of non-communicable diseases in China, 2008–2015
( Springer , 2021 , Article)This article examines the health system performance impact of China’s new round of healthcare reform adopted in 2009. Specifically, we evaluated productivity and efficiency of health production pre- and post-reform period, ... -
COVID-19 exit strategy during vaccine implementation: a balance between social distancing and herd immunity
( Springer , 2022 , Article Review)Currently, health authorities around the world are struggling to limit the spread of COVID-19. Since the beginning of the pandemic, social distancing has been the most important strategy used by most countries to control ... -
Correction to: Metabolic reprogramming of T regulatory cells in the hypoxic tumor microenvironment (Cancer Immunology, Immunotherapy, (2021), 70, 8, (2103-2121), 10.1007/s00262-020-02842-y)
( Springer , 2021 , Article)in the hypoxic tumor microenvironment, written by Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Farhan S. Cyprian and Eyad Elkord, was originally published electronically on the publisher’s internet portal on 03 ... -
Correction to: 68Ga-PSMA PET/CT tumour intensity pre-operatively predicts adverse pathological outcomes and progression-free survival in localised prostate cancer
( Springer , 2021 , Article)Figure 2b is incorrect in the original paper, the correct Fig. 2 is shown below: (Figure presented.). -
Oral Vaccine Delivery: The Coming Age of Particulate Vaccines to Elicit Mucosal Immunity
( Springer , 2020 , Book chapter)With the evolution of different challenging diseases, there is an urgent need of vaccine development against them to save millions of lives around the world. Particlulate delivery system plays an important role by acting ... -
Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
( Wiley , 2022 , Article Review)The metabolic syndrome comprises a family of clinical and laboratory findings, including insulin resistance, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein cholesterol levels, and hypertension, in addition ... -
Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort
( Wiley , 2021 , Article)Background: Tangible efforts have been made to identify biomarkers for Parkinson's disease (PD) diagnosis and progression, with α-synuclein (α-syn) related biomarkers being at the forefront. Objectives: The objectives of ... -
Neurotrauma investigation through spatial omics guided by mass spectrometry imaging: Target identification and clinical applications
( Wiley , 2023 , Article Review)Traumatic brain injury (TBI) represents one of the major public health concerns worldwide due to the increase in TBI incidence as a result of injuries from daily life accidents such as sports and motor vehicle transportation ... -
A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer
( Wiley , 2020 , Article)Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ... -
Therapeutic effects of statins on osteoarthritis: A review
( Wiley , 2022 , Article Review)Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ...
