College of Medicine: Recent submissions
Now showing items 781-800 of 1516
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A possible role for inducible arginase isoform (AI) in the pathogenesis of chronic venous leg ulcer
( Wiley , 2020 , Article)Chronic venous ulcer (CVU) is a major cause of chronic wounds of lower extremities and presents a significant financial and resource burden to health care systems worldwide. Defects in the vasculature, matrix deposition, ... -
Therapeutic effects of statins on osteoarthritis: A review
( Wiley , 2022 , Article Review)Osteoarthritis (OA) is a progressive joint disease. The etiology of OA is considered to be multifactorial. Currently, there is no definitive treatment for OA, and the existing treatments are not very effective. ... -
Clinical presentation and outcomes of peripartum cardiomyopathy in the Middle East: a cohort from seven Arab countries
( Wiley , 2020 , Article)Aims: Published data on the clinical presentation of peripartum cardiomyopathy (PPCM) are very limited particularly from the Middle East. The aim of this study was to examine the clinical presentation, management, and ... -
Isolation and identification in human blood serum of the proteins possessing the ability to bind with 48 kDa form of unconventional myosin 1c and their possible diagnostic and prognostic value
( Wiley , 2021 , Article)We firstly identified 48 kDa molecular form of the unconventional myosin 1c (p48/Myo1C), and isolated it from blood serum of multiple sclerosis patients. The amount of p48/Myo1C in human blood serum correlated with some ... -
Novel Post-translational Modifications in Human Serum Albumin
( Bentham , 2022 , Article)Aim: This study aims to identify novel post-translational modifications in human serum albumin by mass spectrometry. Background: Serum albumin is the most abundant protein in plasma, has many physiological functions, and ... -
Targeted and systemic insights into the crosstalk between DNA-dependent protein kinase catalytic subunit and receptors of estrogen, progesterone and epidermal growth factor in the context of cancer
( Springer , 2021 , Article)DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has emerged as a regulator of carcinogenesis. Increased expression of DNA-PKcs correlates with metastatic cancers. Here we review recently reported crosstalk of ... -
Ultrasound controlled paclitaxel releasing system—A novel method for improving the availability of coronary artery drug coated balloon
( Wiley , 2020 , Article)Objectives: The aim of this study is to improve local-drug delivery efficiency and tissue absorption using the ultrasound (US)-responsible drug coating based on a newly developed US-controlled paclitaxel release balloon. ... -
Association of Habitual Alcohol Intake with Risk of Cardiovascular Disease
( American Medical Association , 2022 , Article)Importance: Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible ... -
Sociocultural insights on dementia care-giving in Arab and Muslim communities: The perspectives of family care-givers
( Cambridge University Press , 2022 , Article)Little is known about the experiences of informal family care-giving for persons with ADRD in the context of Arab and Muslim communities. This paper offers fresh insight into the less-studied private sphere of the home, ... -
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
( Walter de Gruyter , 2022 , Article)Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ... -
Screening for diabetes and impaired glucose metabolism in Qatar: Models’ development and validation
( Elsevier , 2021 , Article)AimTo establish two scoring models for identifying individuals at risk of developing Impaired Glucose Metabolism (IGM) or Type two Diabetes Mellitus (T2DM) in Qatari. Materials and methodsA sample of 2000 individuals, from ... -
Review of Post-translational Modification of Human Serum Albumin
( Bentham , 2022 , Article)Post-translational modifications (PTMs) may affect the functions of human serum albumin. Here we review reports of novel PTMs of human serum albumin. This study reviewed one hundred twenty-three recently reported novel ... -
Rare coding variants in 35 genes associate with circulating lipid levels—A multi-ancestry analysis of 170,000 exomes
( Elsevier , 2022 , Article)Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele ... -
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
( Elsevier , 2023 , Article)AimsTraumatic brain injury (TBI) constitutes a serious public health concern. Although TBI targets the brain, it can exert several systemic effects which can worsen the complications observed in TBI subjects. Currently, ... -
Diagnostic Value of Non-invasive Liver Function Tests in Liver Fibrosis and Changes in These Parameters Post-metabolic Surgery
( Springer , 2023 , Article)Purpose: This study aimed to ascertain the diagnostic accuracy of non-invasive liver function tests in liver fibrosis and assess their changes after metabolic surgery. Materials and Methods: 1005 individuals with severe ... -
Papaver Plants: Current Insights on Phytochemical and Nutritional Composition Along with Biotechnological Applications
( Hindawi , 2022 , Article)The genus Papaver is highly esteemed in the pharmacy industry, in the culinary field, and as ornamental plants. These plants are also valued in traditional medicine. Among all Papaver species, Papaver somniferum L. (opium ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
G protein estrogen receptor as a potential therapeutic target in Raynaud’s phenomenon
( Frontiers Media , 2022 , Article)Exaggerated cold-induced vasoconstriction can precipitate a pathogenesis called Raynaud’s phenomenon (RP). Interestingly, RP is significantly more prevalent in females than age-matched men, highlighting the potential ... -
Estrogen receptor and the gender bias in Raynaud's phenomenon.
( Bentham Science Publishers , 2023 , Article)Cold-induced vasoconstriction is a normal physiological reaction aiming at redirecting blood into internal more vital body organs [1]. It is mediated by sympathetic release of norepinephrine as well as by local effectors ... -
The effect of nuts consumption on circulating oxidized low-density lipoproteins: A systematic review and meta-analysis of randomized controlled trials.
( Wiley , 2023 , Article Review)This systematic review and meta-analysis evaluated the effect of nuts in decreasing circulating levels of oxidized low-density lipoproteins (ox-LDL). A literature search was performed of major electronic databases ...
