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AuthorWedn, Abdalla M.
AuthorEl-Bassossy, Hany M.
AuthorEid, Ali H.
AuthorEl-Mas, Mahmoud M.
Available date2023-05-10T03:55:28Z
Publication Date2021-10-01
Publication NameBiochemical Pharmacology
Identifierhttp://dx.doi.org/10.1016/j.bcp.2021.114703
ISSN00062952
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85111552730&origin=inward
URIhttp://hdl.handle.net/10576/42520
AbstractThe cholinergic anti-inflammatory pathway (CAP) is vital for the orchestration of the immune and inflammatory responses under normal and challenged conditions. Over the past two decades, peripheral and central circuits of CAP have been shown to be critically involved in dampening the inflammatory reaction in a wide array of inflammatory disorders. Additionally, emerging evidence supports a key role for CAP in the regulation of the female reproductive system during gestation as well as in the advent of serious pregnancy-related inflammatory insults such as preeclampsia (PE). Within this framework, the modulatory action of CAP encompasses the perinatal maternal and fetal adverse consequences that surface due to antenatal PE programming. Albeit, a considerable gap still exists in our knowledge of the precise cellular and molecular underpinnings of PE/CAP interaction, which hampered global efforts in safeguarding effective preventive or therapeutic measures against PE complications. Here, we summarize reports in the literature regarding the roles of peripheral and reflex cholinergic neuroinflammatory pathways of nicotinic acetylcholine receptors (nAChRs) in reprogramming PE complications in mothers and their progenies. The possible contributions of α7-nAChRs, cholinesterases, immune cells, adhesion molecules, angiogenesis, and endothelial dysfunction to the interaction have also been reviewed.
SponsorSupported by the Science and Technology Development Fund, Egypt (STDF Grant No. 14895).
Languageen
PublisherElsevier
SubjectCholinergic anti-inflammatory pathway
Fetal complications
Inflammation
Nicotinic acetylcholine receptors
Placenta
Preeclampsia
TitleModulation of preeclampsia by the cholinergic anti-inflammatory pathway: Therapeutic perspectives
TypeArticle Review
Volume Number192
dc.accessType Open Access


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