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المؤلفShouk, Reem
المؤلفAbdou, Aya
المؤلفShetty, Kalidas
المؤلفSarkar, Dipayan
المؤلفEid, Ali H.
تاريخ الإتاحة2016-04-18T08:10:04Z
تاريخ النشر2014-02
اسم المنشورNutrition Research
المصدرScopus
المعرّفhttp://dx.doi.org/10.1016/j.nutres.2013.12.005
الاقتباسShouk, R., Abdou, A., Shetty, K., Sarkar, D., Eid, A.H. "Mechanisms underlying the antihypertensive effects of garlic bioactives" (2014) Nutrition Research, 34 (2), pp. 106-115.
الرقم المعياري الدولي للكتاب0271-5317
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4394
الملخصCardiovascular disease remains the leading cause of death worldwide with hypertension being a major contributing factor to cardiovascular disease–associated mortality. On a population level, non-pharmacological approaches, such as alternative/complementary medicine, including phytochemicals, have the potential to ameliorate cardiovascular risk factors, including high blood pressure. Several epidemiological studies suggest an antihypertensive effect of garlic (Allium sativum) and of many its bioactive components. The aim of this review is to present an in-depth discussion regarding the molecular, biochemical and cellular rationale underlying the antihypertensive properties of garlic and its bioactive constituents with a primary focus on S-allyl cysteine and allicin. Key studies, largely from PubMed, were selected and screened to develop a comprehensive understanding of the specific role of garlic and its bioactive constituents in the management of hypertension. We also reviewed recent advances focusing on the role of garlic bioactives, S-allyl cysteine and allicin, in modulating various parameters implicated in the pathogenesis of hypertension. These parameters include oxidative stress, nitric oxide bioavailability, hydrogen sulfide production, angiotensin converting enzyme activity, expression of nuclear factor–κB and the proliferation of vascular smooth muscle cells. This review suggests that garlic and garlic derived bioactives have significant medicinal properties with the potential for ameliorating hypertension and associated morbidity; however, further clinical and epidemiological studies are required to determine completely the specific physiological and biochemical mechanisms involved in disease prevention and management.
راعي المشروعgrant # NPRP 4-571-3-171 from the Qatar National Research Fund (a member of Qatar Foundation).
اللغةen
الناشرElsevier Inc.
الموضوعAllicin
Allium sativum
Garlic
Hypertension
S-Allyl cysteine
Angiotensin-converting enzyme
Cardiovascular disease
Diastolic blood pressure
Systolic blood pressure
Vascular smooth muscle cell
العنوانMechanisms underlying the antihypertensive effects of garlic bioactives
النوعArticle
الصفحات106-115
رقم العدد2
رقم المجلد34
dc.accessType Abstract Only


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