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المؤلفElsayed, Abdalla Moustafa
المؤلفAl-Kaabi, Latifa Saad
المؤلفAl-Abdulla, Noora Mohammed
المؤلفAl-Kuwari, Moza Salem
المؤلفAl-Mulla, Asmaa Abdulsamad
المؤلفAl-Shamari, Raghad Shaher
المؤلفAlhusban, Ahmed Khaled
المؤلفAlNajjar, Ali Ahmed
المؤلفDoi, Suhail A.R.
تاريخ الإتاحة2023-06-18T10:00:34Z
تاريخ النشر2023-05-22
اسم المنشورReproductive Sciences
المعرّفhttp://dx.doi.org/10.1007/s43032-023-01262-4
الاقتباسElsayed, A. M., Al-Kaabi, L. S., Al-Abdulla, N. M., Al-Kuwari, M. S., Al-Mulla, A. A., Al-Shamari, R. S., ... & AlNajjar, A. A. (2023). Clinical Phenotypes of PCOS: a Cross-Sectional Study. Reproductive Sciences, 1-12.
الرقم المعياري الدولي للكتاب1933-7191
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85160050471&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/44513
الملخصThis cross-sectional study examines the Doi-Alshoumer PCOS clinical phenotype classification in relation to measured clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Two cohorts of women (Kuwait and Rotterdam) diagnosed with PCOS (FAI > 4.5%) were examined. These phenotypes were created using neuroendocrine dysfunction (IRMA LH/FSH ratio > 1 or LH > 6 IU/L) and menstrual cycle status (oligo/amenorrhea) to create three phenotypes: (A) neuroendocrine dysfunction and oligo/amenorrhea, (B) without neuroendocrine dysfunction but with oligo/amenorrhea, and (C) without neuroendocrine dysfunction and with regular cycles. These phenotypes were compared in terms of hormonal, biochemical, and anthropometric measures. The three suggested phenotypes (A, B, and C) were shown to be sufficiently distinct in terms of hormonal, biochemical, and anthropometric measures. Patients who were classified as phenotype A had neuroendocrine dysfunction, excess LH (and LH/FSH ratio), irregular cycles, excess A4, infertility, excess T, highest FAI and E2, and excess 17αOHPG when compared to the other phenotypes. Patients classified as phenotype B had irregular cycles, no neuroendocrine dysfunction, obesity, acanthosis nigricans, and insulin resistance. Lastly, patients classified as phenotype C had regular cycles, acne, hirsutism, excess P4, and the highest P4 to E2 molar ratio. The differences across phenotypes suggested distinct phenotypic expression of this syndrome, and the biochemical and clinical correlates of each phenotype are likely to be useful in the management of women with PCOS. These phenotypic criteria are distinct from criteria used for diagnosis.
اللغةen
الناشرSpringer
الموضوعAndrostenedione
Doi-Alshoumer classification
Hirsutism
Insulin resistance
Phenotype
Polycystic ovary syndrome
Rotterdam criteria
العنوانClinical Phenotypes of PCOS: a Cross-Sectional Study
النوعArticle
الصفحات1-12
ESSN1933-7205
dc.accessType Open Access


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