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AuthorElsayed, Abdalla Moustafa
AuthorAl-Kaabi, Latifa Saad
AuthorAl-Abdulla, Noora Mohammed
AuthorAl-Kuwari, Moza Salem
AuthorAl-Mulla, Asmaa Abdulsamad
AuthorAl-Shamari, Raghad Shaher
AuthorAlhusban, Ahmed Khaled
AuthorAlNajjar, Ali Ahmed
AuthorDoi, Suhail A.R.
Available date2023-06-18T10:00:34Z
Publication Date2023-05-22
Publication NameReproductive Sciences
Identifierhttp://dx.doi.org/10.1007/s43032-023-01262-4
CitationElsayed, A. M., Al-Kaabi, L. S., Al-Abdulla, N. M., Al-Kuwari, M. S., Al-Mulla, A. A., Al-Shamari, R. S., ... & AlNajjar, A. A. (2023). Clinical Phenotypes of PCOS: a Cross-Sectional Study. Reproductive Sciences, 1-12.
ISSN1933-7191
URIhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85160050471&origin=inward
URIhttp://hdl.handle.net/10576/44513
AbstractThis cross-sectional study examines the Doi-Alshoumer PCOS clinical phenotype classification in relation to measured clinical and biochemical characteristics of women with polycystic ovary syndrome (PCOS). Two cohorts of women (Kuwait and Rotterdam) diagnosed with PCOS (FAI > 4.5%) were examined. These phenotypes were created using neuroendocrine dysfunction (IRMA LH/FSH ratio > 1 or LH > 6 IU/L) and menstrual cycle status (oligo/amenorrhea) to create three phenotypes: (A) neuroendocrine dysfunction and oligo/amenorrhea, (B) without neuroendocrine dysfunction but with oligo/amenorrhea, and (C) without neuroendocrine dysfunction and with regular cycles. These phenotypes were compared in terms of hormonal, biochemical, and anthropometric measures. The three suggested phenotypes (A, B, and C) were shown to be sufficiently distinct in terms of hormonal, biochemical, and anthropometric measures. Patients who were classified as phenotype A had neuroendocrine dysfunction, excess LH (and LH/FSH ratio), irregular cycles, excess A4, infertility, excess T, highest FAI and E2, and excess 17αOHPG when compared to the other phenotypes. Patients classified as phenotype B had irregular cycles, no neuroendocrine dysfunction, obesity, acanthosis nigricans, and insulin resistance. Lastly, patients classified as phenotype C had regular cycles, acne, hirsutism, excess P4, and the highest P4 to E2 molar ratio. The differences across phenotypes suggested distinct phenotypic expression of this syndrome, and the biochemical and clinical correlates of each phenotype are likely to be useful in the management of women with PCOS. These phenotypic criteria are distinct from criteria used for diagnosis.
Languageen
PublisherSpringer
SubjectAndrostenedione
Doi-Alshoumer classification
Hirsutism
Insulin resistance
Phenotype
Polycystic ovary syndrome
Rotterdam criteria
TitleClinical Phenotypes of PCOS: a Cross-Sectional Study
TypeArticle
Pagination1-12
ESSN1933-7205
dc.accessType Open Access


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