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المؤلفMir, Fayaz Ahmad
المؤلفMall, Raghvendra
المؤلفIskandarani, Ahmad
المؤلفUllah, Ehsan
المؤلفSamra, Tareq A
المؤلفCyprian, Farhan
المؤلفParray, Aijaz
المؤلفAlkasem, Meis
المؤلفAbdalhakam, Ibrahem
المؤلفFarooq, Faisal
المؤلفAbou-Samra, Abdul-Badi
تاريخ الإتاحة2023-07-09T10:40:04Z
تاريخ النشر2022-07
اسم المنشورFrontiers in Endocrinology
المعرّف10.3389/fendo.2022.937089
المعرّفhttp://dx.doi.org/10.3389/fendo.2022.937089
الاقتباسMir, F. A., Mall, R., Iskandarani, A., Ullah, E., Samra, T. A., Cyprian, F., ... & Abou-Samra, A. B. (2022). Characteristic MicroRNAs linked to dysregulated metabolic pathways in qatari adult subjects with obesity and metabolic syndrome. Frontiers in Endocrinology, 13, 937089.‏
معرّف المصادر الموحدhttp://hdl.handle.net/10576/45166
الملخصObesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in obese Qatari individuals. We analyzed a dataset of 39 age-matched patients that includes 18 subjects with obesity only (OBO) and 21 subjects with obesity and metabolic syndrome (OBM). We measured 754 well-characterized human microRNAs (miRNAs) and identified differentially expressed miRNAs along with their significant associations with clinical markers in these patients. A total of 64 miRNAs were differentially expressed between metabolically healthy obese (OBO) versus metabolically unhealthy obese (OBM) patients. Thirteen out of 64 miRNAs significantly correlated with at least one clinical trait of the metabolic syndrome. Six out of the thirteen demonstrated significant association with HbA1c levels; miR-331-3p, miR-452-3p, and miR-485-5p were over-expressed, whereas miR-153-3p, miR-182-5p, and miR-433-3p were under-expressed in the OBM patients with elevated HbA1c levels. We also identified, miR-106b-3p, miR-652-3p, and miR-93-5p that showed a significant association with creatinine; miR-130b-5p, miR-363-3p, and miR-636 were significantly associated with cholesterol, whereas miR-130a-3p was significantly associated with LDL. Additionally, miR-652-3p's differential expression correlated significantly with HDL and creatinine. MicroRNAs associated with metabolic syndrome in obese subjects may have a pathophysiologic role and can serve as markers for obese individuals predisposed to various metabolic diseases like diabetes.
اللغةen
الناشرFrontiers
الموضوعHbA1c
metabolic disorder
miRNA
mirDIP
network analysis
obesity
العنوانCharacteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome.
النوعArticle
رقم المجلد13
dc.accessType Open Access


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