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AuthorMir, Fayaz Ahmad
AuthorMall, Raghvendra
AuthorIskandarani, Ahmad
AuthorUllah, Ehsan
AuthorSamra, Tareq A
AuthorCyprian, Farhan
AuthorParray, Aijaz
AuthorAlkasem, Meis
AuthorAbdalhakam, Ibrahem
AuthorFarooq, Faisal
AuthorAbou-Samra, Abdul-Badi
Available date2023-07-09T10:40:04Z
Publication Date2022-07
Publication NameFrontiers in Endocrinology
Identifier10.3389/fendo.2022.937089
Identifierhttp://dx.doi.org/10.3389/fendo.2022.937089
CitationMir, F. A., Mall, R., Iskandarani, A., Ullah, E., Samra, T. A., Cyprian, F., ... & Abou-Samra, A. B. (2022). Characteristic MicroRNAs linked to dysregulated metabolic pathways in qatari adult subjects with obesity and metabolic syndrome. Frontiers in Endocrinology, 13, 937089.‏
URIhttp://hdl.handle.net/10576/45166
AbstractObesity-associated dysglycemia is associated with metabolic disorders. MicroRNAs (miRNAs) are known regulators of metabolic homeostasis. We aimed to assess the relationship of circulating miRNAs with clinical features in obese Qatari individuals. We analyzed a dataset of 39 age-matched patients that includes 18 subjects with obesity only (OBO) and 21 subjects with obesity and metabolic syndrome (OBM). We measured 754 well-characterized human microRNAs (miRNAs) and identified differentially expressed miRNAs along with their significant associations with clinical markers in these patients. A total of 64 miRNAs were differentially expressed between metabolically healthy obese (OBO) versus metabolically unhealthy obese (OBM) patients. Thirteen out of 64 miRNAs significantly correlated with at least one clinical trait of the metabolic syndrome. Six out of the thirteen demonstrated significant association with HbA1c levels; miR-331-3p, miR-452-3p, and miR-485-5p were over-expressed, whereas miR-153-3p, miR-182-5p, and miR-433-3p were under-expressed in the OBM patients with elevated HbA1c levels. We also identified, miR-106b-3p, miR-652-3p, and miR-93-5p that showed a significant association with creatinine; miR-130b-5p, miR-363-3p, and miR-636 were significantly associated with cholesterol, whereas miR-130a-3p was significantly associated with LDL. Additionally, miR-652-3p's differential expression correlated significantly with HDL and creatinine. MicroRNAs associated with metabolic syndrome in obese subjects may have a pathophysiologic role and can serve as markers for obese individuals predisposed to various metabolic diseases like diabetes.
Languageen
PublisherFrontiers
SubjectHbA1c
metabolic disorder
miRNA
mirDIP
network analysis
obesity
TitleCharacteristic MicroRNAs Linked to Dysregulated Metabolic Pathways in Qatari Adult Subjects With Obesity and Metabolic Syndrome.
TypeArticle
Volume Number13
dc.accessType Open Access


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