Browsing Biomedical Research Center Research by Author "Yalcin, Huseyin C."
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Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish.
Benslimane, Fatiha M; Alser, Maha; Zakaria, Zain Z; Sharma, Anju; Abdelrahman, Hana A; Yalcin, Huseyin C... more authors ... less authors ( Frontiers Media , 2019 , Article)Ultrasonography is the most widely used imaging technique in cardiovascular medicine. In this technique, a piezoelectric crystal produces, sends, and receives high frequency ultrasound waves to the body to create an image ... -
Application of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber
Shurbaji, Samar; Al-Ruweidi, Mahmoud Khatib A.A.; Ali, Fatma Hassan; Benslimane, Fatiha M.; Yalcin, Huseyin C. ( MDPI , 2020 , Article)© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications ... -
Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
Amindari, Armin; Saltik, Levent; Kirkkopru, Kadir; Yacoub, Magdi; Yalcin, Huseyin C. ( Elsevier , 2017 , Article)Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via ... -
Assessment of calcified aortic valve leaflet deformations and blood flow dynamics using fluid-structure interaction modeling
Armin, Amindari; Saltik, Levent; Kirkkopru, Kadir; Yacoub, Magdi; Yalcin, Huseyin C. ( Elsevier , 2017 , Article)Aortic valve diseases are among the most common cardiovascular defects. Since a non-functioning valve results in disturbed blood flow conditions, the diagnosis of such defects is based on identification of stenosis via ... -
Assessment of Human Fetal Left Heart Hemodynamics during Prenatal Development
Yalcin, Huseyin C.; Salman, Huseyin E; Kamal, Reema Y. ( Qatar University Press , 2021 , Poster)The hemodynamic forces and wall shear stresses (WSS) play an important role during the fetal heart development. Abnormal levels of flow-driven shear stress can deteriorate the proper functioning of the cells responsible ... -
Autoimmune Diseases of the GI Tract Part I: Etiology and Pathophysiology
Al-Ruweidi, Mahmoud Khatib A.A.; Khater, Nada; Alkaabi, Haya Rashid; Hasan, Maram; Yalcin, Huseyin C. ( IntechOpen , 2022 , Book chapter)Autoimmune diseases have emerged as a pandemic in our modern societies, especially after World War II. There are currently more than 80 autoimmune diseases that compromise the lives of millions of patients around the world. ... -
Autoimmune Diseases of the GI Tract Part II: Emergence of Diagnostic Tools and Treatments
Al-Ruweidi, Mahmoud Khatib A.A.; Khater, Nada; Alkaabi, Haya Rashid; Hasan, Maram; Murtaza, Mohammed; Yalcin, Huseyin C.... more authors ... less authors ( IntechOpen , 2022 , Book chapter)Autoimmune diseases (AD) have emerged as a pandemic in our modern societies, especially after the World War II. In part I, we have reviewed five main diseases and shed light on different aspects from introducing the concept ... -
Cardiac function and blood flow hemodynamics assessment of zebrafish (Danio rerio) using high-speed video microscopy
Fatiha M., Benslimane; Zakaria, Zain Z.; Shurbaji, Samar; Abdelrasool, Mahmoud Khatib Ali; Al-Badr, Mashael Ali H.I.; Al Absi, Enas Said Khalil; Yalcin, Huseyin C.... more authors ... less authors ( Elsevier , 2020 , Article)BackgroundIn the last few decades, zebrafish (Danio rerio) were introduced as a model organism to investigate human diseases including cardiovascular and neuronal disorders. In most zebrafish investigations, cardiac function ... -
Characterization of Endothelial Cilia Distribution During Cerebral-Vascular Development in Zebrafish (Danio rerio)
Eisa-Beygi, Shahram; Benslimane, Fatiha M.; El-Rass, Suzan; Prabhudesai, Shubhangi; Abdelrasoul, Mahmoud Khatib Ali; Simpson, Pippa M.; yalcin, Huseyin C.; Burrows, Patricia E.; Ramchandran, Ramani... more authors ... less authors ( American Heart Association , 2018 , Article)Objective—Endothelial cells (ECs) sense and respond to flow-induced mechanical stress, in part, via microtubule-based projections called primary cilia. However, many critical steps during vascular morphogenesis occur ... -
Characterization of MXene as a Cancer Photothermal Agent Under Physiological Conditions
Shurbaji, Samar; Manaph, Nimshitha P. Abdul; Ltaief, Samia M.; Al-Shammari, Abeer R.; Elzatahry, Ahmed; Yalcin, Huseyin C.... more authors ... less authors ( Frontiers Media , 2021 , Article)A growing interest has recently emerged in the use of nanomaterials in medical applications. Nanomaterials, such as MXene, have unique properties due to their 2D ultra-thin structure, which is potentially useful in cancer ... -
Cilia proteins are biomarkers of altered flow in the vasculature
Gupta, Ankan; Thirugnanam, Karthikeyan; Thamilarasan, Madhan; Mohieldin, Ashraf M.; Zedan, Hadeel T.; Prabhudesai, Shubhangi; Griffin, Meghan R.; Spearman, Andrew D.; Pan, Amy; Palecek, Sean P.; Yalcin, Huseyin C.; Nauli, Surya M.; Rarick, Kevin R.; Zennadi, Rahima; Ramchandran, Ramani... more authors ... less authors ( American Society for Clinical Investigation , 2022 , Article)Cilia, microtubule-based organelles that project from the apical luminal surface of endothelial cells (ECs), are widely regarded as low-flow sensors. Previous reports suggest that upon high shear stress, cilia on the EC ... -
Computational Analysis of Wall Shear Stress Patterns on Calcified and Bicuspid Aortic Valves : Focus on Radial and Coaptation Patterns
Salman, Huseyin Enes; Saltik, Levent; Yalcin, Huseyin C. ( MDPI , 2021 , Article)Calcification and bicuspid valve formation are important aortic valve disorders that disturb the hemodynamics and the valve function. The detailed analysis of aortic valve hemodynamics would lead to a better understanding ... -
Deep Learning Technique for Congenital Heart Disease Detection Using Stacking-Based CNN-LSTM Models from Fetal Echocardiogram: A Pilot Study
Rahman, Tawsifur; Al-Ruweidi, Mahmoud Khatib A.A.; Sumon, Md Shaheenur Islam; Kamal, Reema Yousef; Chowdhury, Muhammad E.H.; Yalcin, Huseyin C.... more authors ... less authors ( IEEE , 2023 , Article)Congenital heart defects (CHDs) are a leading cause of death in infants under 1 year of age. Prenatal intervention can reduce the risk of postnatal serious CHD patients, but current diagnosis is based on qualitative criteria, ... -
Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development
Zakaria, Zain Zaki; Eisa-Beygi, Shahram; Benslimane, Fatiha; Ramchandran4, Ramani; Yalcin, Huseyin C. ( MyJove Corporation , 2022 , Article)The morpholino oligomer-based knockdown system has been used to identify the function of various gene products through loss or reduced expression. Morpholinos (MOs) have the advantage in biological stability over DNA oligos ... -
Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model
Zakaria, Zain Z; Mahmoud, Nouf N; Benslimane, Fatiha M; Yalcin, Huseyin C.; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( American Chemical Society , 2022 , Article)Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ... -
Dexamethasone and transdehydroandrosterone significantly reduce pulmonary epithelial cell injuries associated with mechanical ventilation.
Al-Ruweidi, Mahmoud Khatib A A; Ali, Fatma Hassan; Shurbaji, Samar; Popelka, Anton; Yalcin, Huseyin C ( American Physiological Society , 2021 , Article)Many patients who suffer from pulmonary diseases cannot inflate their lungs normally, as they need mechanical ventilation (MV) to assist them. The stress associated with MV can damage the delicate epithelium in small airways ... -
Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway
Maram, Hasan; Al-Thani, Hassan; El-Menyar, Ayman; Zeidan, Asad; Al-Thani, Asmaa; Yalcin, Huseyin C.... more authors ... less authors ( Elsevier , 2023 , Article Review)Hemodynamic shear stress is one of the major factors that are involved in the pathogenesis of many cardiovascular diseases including atherosclerosis and abdominal aortic aneurysm (AAA), through its modulatory effect on the ... -
Do changes in ace-2 expression affect sars-cov-2 virulence and related complications: A closer look into membrane-bound and soluble forms
Yalcin, Huseyin C.; Sukumaran, Vijayakumar; Al-Ruweidi, Mahmoud Khatib A.A.; Shurbaji, Samar ( MDPI , 2021 , Article Review)The SARS-CoV-2 virus utilizes angiotensin converting enzyme (ACE-2) for cell entry and infection. This enzyme has important functions in the renin-angiotensin aldosterone system to preserve cardiovascular function. In ... -
Editorial: Advances in techniques for measurement and assessment of physiological processes in developing animals
Yalcin, Huseyin C.; Khandoker, Ahsan H.; Kawakami, Koichi ( Frontiers Media , 2023 , Other)Developmental Physiology can be broadly defined as the field of science aiming to understand the physiological processes shaping a fertilized egg of a species into a wellstructured and functional multi-cellular organism. ... -
Editorial: Emerging mechanisms in cardiovascular disease
Yalcin, Huseyin C.; Caiazzo, Elisabetta; Ialenti, Armando; Eid, Ali H. ( Frontiers Media , 2023 , Other)Editorial on the Research Topic Emerging mechanisms in cardiovascular disease The leading cause of worldwide mortality is cardiovascular disease (CVD) (Aboukhater et al., 2023). Despite many significant advances in the ...