تصفح Biomedical Research Center Research حسب المؤلف "Al-Khal, Abdullatif"
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A new One Health Framework in Qatar for future emerging and re-emerging zoonotic diseases preparedness and response
Devendra, Bansal; Jaffrey, Shariq; Al-Emadi, Noora Abdulla; Hassan, Mahmoud; Islam, Md. Mazharul; Al-Baker, Wasan Abdulla A.; Radwan, Eman; Hamdani, Dhouha; Haroun, Mohammed Ismail; Enan, Khalid; Nour, Mohammed; Coyle, Peter Valentine; Al Marri, Abdulla; Al-Zeyara, Abdul Aziz; Younus, Nidal M.; Yassine, Hadi Mohamad; Al Thani, Asmaa Ali; Darkhshan, Fatima; Khalid, Minahil; Marhous, Heba; Tibbo, Markos; Alhosani, Mohamed; Taha, Tariq; Wannous, Chadia; Al Hajri, Mohamed; Bertollini, Roberto; Al-Maslamani, Muna A.; Al Khal, Abdullatif; Al Romaihi, Hamad Eid; Al Thani, Sheikh Mohammed Bin Hamad Bin J.; El Idrissi, Ahmed; Farag, Elmoubashar Abd... more authors ... less authors ( Elsevier , 2023 , Article)One Health is increasingly recognized as an optimal approach to address the global risk of health threats originating at the human, animal, and ecosystem interface, and their impact. Qatar has successfully practiced One ... -
One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar
Benslimane, Fatiha M; Al Khatib, Hebah A; Al-Jamal, Ola; Albatesh, Dana; Boughattas, Sonia; Ahmed, Ayeda A; Bensaad, Meryem; Younuskunju, Shameem; Mohamoud, Yasmin A; Al Badr, Mashael; Mohamed, Abdalla A; El-Kahlout, Reham A; Al-Hamad, Tasneem; Elgakhlab, Dina; Al-Kuwari, Fatima H; Saad, Chadi; Jeremijenko, Andrew; Al-Khal, Abdullatif; Al-Maslamani, Muna A; Bertollini, Roberto; Al-Kuwari, Einas A; Al-Romaihi, Hamad E; Al-Marri, Salih; Al-Thani, Mohammed; Badji, Radja M; Mbarek, Hamdi; Al-Sarraj, Yasser; Malek, Joel A; Ismail, Said I; Abu-Raddad, Laith J; Coyle, Peter V; Thani, Asmaa A Al; Yassine, Hadi M... more authors ... less authors ( Frontiers , 2021 , Article)Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome ... -
Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies
Hadi M., Yassine; Al-Jighefee, Hadeel; Al-Sadeq, Duaa W.; Dargham, Soha R.; Younes, Salma N.; Shurrab, Farah; Marei, Reham M.; Hssain, Ali Ait; Taleb, Sara; Alhussain, Hashim A.; Al-Nesf, Maryiam A.; Al-Khal, Abdullatif; Qotba, Hamda; Althani, Asmaa A.; Tang, Patrick; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2020 , Article)ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ... -
Population immunity of natural infection, primary-series vaccination, and booster vaccination in Qatar during the COVID-19 pandemic: an observational study
Suelen H., Qassim; Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Khatib, Hebah A.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A.; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Elsevier , 2023 , Article)BackgroundWaning of natural infection protection and vaccine protection highlight the need to evaluate changes in population immunity over time. Population immunity of previous SARS-CoV-2 infection or of COVID-19 vaccination ... -
Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications
Al-Nesf, Maryam A. Y.; Abdesselem, Houari B.; Bensmail, Ilham; Ibrahim, Shahd; Saeed, Walaa A. H.; Mohammed, Sara S. I.; Razok, Almurtada; Alhussain, Hashim; Aly, Reham M. A.; Al Maslamani, Muna; Ouararhni, Khalid; Khatib, Mohamad Y.; Hssain, Ali Ait; Omrani, Ali S.; Al-Kaabi, Saad; Al Khal, Abdullatif; Al-Thani, Asmaa A.; Samsam, Waseem; Farooq, Abdulaziz; Al-Suwaidi, Jassim; Al-Maadheed, Mohammed; Al-Siddiqi, Heba H.; Butler, Alexandra E.; Decock, Julie V.; Mohamed-Ali, Vidya; Al-Ejeh, Fares... more authors ... less authors ( Nature Research , 2022 , Article)COVID-19 complications still present a huge burden on healthcare systems and warrant predictive risk models to triage patients and inform early intervention. Here, we profile 893 plasma proteins from 50 severe and 50 ... -
Protection against Reinfection with the Omicron BA.2.75 Subvariant
Chemaitelly, Hiam; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al-Khatib, Hebah A.; Smatti, Maria K.; Hasan, Mohammad R.; Ayoub, Houssein H.; Altarawneh, Heba N.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H.; Latif, Ali N.; Shaik, Riyazuddin M.; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed G.; Butt, Adeel A.; Al-Romaihi, Hamad E.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Massachusetts Medical Society , 2023 , Other)The BA.2.75 sublineage of the B.1.1.529 (omicron) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may escape neutralizing antibodies. The BA.2.75 sublineage (primarily the BA.2.75.2 subvariant) ... -
Protection against the omicron variant from previous SARS-CoV-2 infection
Altarawneh, Heba N.; Chemaitelly, Hiam; Hasan, Mohammad R.; Ayoub, Houssein H.; Qassim, Suelen; AlMukdad, Sawsan; Coyle, Peter; Yassine, Hadi M.; Al-Khatib, Hebah A.; Benslimane, Fatiha M.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H.; Latif, Ali N.; Shaik, Riyazuddin M.; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed G.; Butt, Adeel A.; Al-Romaihi, Hamad E.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Tang, Patrick; Abu-Raddad, Laith J.... more authors ... less authors ( Massachusetts Medical Society , 2022 , Other)Natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits strong protection against reinfection with the B.1.1.7 (alpha),1,2 B.1.351 (beta),1 and B.1.617.2 (delta)3 variants. However, the ... -
Protection from previous natural infection compared with mRNA vaccination against SARS-CoV-2 infection and severe COVID-19 in Qatar: a retrospective cohort study
Hiam, Chemaitelly; Ayoub, Houssein H; AlMukdad, Sawsan; Coyle, Peter; Tang, Patrick; Yassine, Hadi M; Al-Khatib, Hebah A; Smatti, Maria K; Hasan, Mohammad R; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F; Nasrallah, Gheyath K; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J... more authors ... less authors ( Elsevier , 2022 , Article)BackgroundUnderstanding protection conferred by natural SARS-CoV-2 infection versus COVID-19 vaccination is important for informing vaccine mandate decisions. We compared protection conferred by natural infection versus ... -
Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage
Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; Al-Khatib, Hebah A.; Smatti, Maria K.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A.; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Nature Research , 2022 , Article)There is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other ... -
Protective Effect of Previous SARS-CoV-2 Infection against Omicron BA.4 and BA.5 Subvariants.
Altarawneh, Heba N; Chemaitelly, Hiam; Ayoub, Houssein H; Hasan, Mohammad R; Coyle, Peter; Yassine, Hadi M; Al-Khatib, Hebah A; Smatti, Maria K; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H; Latif, Ali N; Shaik, Riyazuddin M; Abdul-Rahim, Hanan F; Nasrallah, Gheyath K; Al-Kuwari, Mohamed G; Butt, Adeel A; Al-Romaihi, Hamad E; Al-Thani, Mohamed H; Al-Khal, Abdullatif; Bertollini, Roberto; Tang, Patrick; Abu-Raddad, Laith J... more authors ... less authors ( Massachusetts Medical Society , 2022 , Article)The BA.4 and BA.5 subvariants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 (omicron) variant have shown the capacity of escaping from neutralizing antibodies.1 These subvariants had an ... -
Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar
R. Hasan, Mohammad; K.R. Kalikiri, Mahesh; Mirza, Faheem; Sundararaju, Sathyavathi; Sharma, Anju; Xaba, Thabisile; Lorenz, Stephan; Chemaitelly, Hiam; A. El-Kahlout, Reham; Ming Tsui, Kin; M. Yassine, Hadi; V. Coyle, Peter; Al Khal, Abdullatif; Bertollini, Roberto; H. Al Thani, Mohamed; J. Abu-Raddad, Laith; Tang, Patrick... more authors ... less authors ( Elsevier , 2021 , Article)Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves ... -
Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections.
Abu-Raddad, Laith J; Chemaitelly, Hiam; Ayoub, Houssein H; Tang, Patrick; Coyle, Peter; Hasan, Mohammad R; Yassine, Hadi M; Benslimane, Fatiha M; Al-Khatib, Hebah A; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F; Nasrallah, Gheyath K; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A; Al-Romaihi, Hamad Eid; Al-Khal, Abdullatif; Al-Thani, Mohametabd H; Bertollini, Roberto... more authors ... less authors ( Springer , 2022 , Article)SARS-CoV-2 breakthrough infections in vaccinated individuals and in those who had a prior infection have been observed globally, but the transmission potential of these infections is unknown. The RT-qPCR cycle threshold ... -
Reporting of RT-PCR cycle threshold (Ct) values during the first wave of COVID-19 in Qatar improved result interpretation in clinical and public health settings
V. Coyle, Peter; Hassan Al Molawi, Naema; Ali Ben Hadj Kacem, Mohamed; Awni El Kahlout, Reham; Al Kuwari, Einas; Al Khal, Abdullatif; Gillani, Imtiaz; Jeremijenko, Andrew; Saeb, Hatoun; Al Thani, Mohammad; Bertollini, Roberto; F. Abdul Rahim, Hanan; Chemaitelly, Hiam; Tang, Patrick; Nizar Latif, Ali; Al Kaabi, Saad; A. Rahman S. Al Maslamani, Muna; David Morris, Brendan; Al-Ansari, Nasser; Hassan Kaleeckal, Anvar; J. Abu Raddad, Laith... more authors ... less authors ( Microbiology Society , 2022 , Article)Introduction. The cycle threshold (Ct) value in real-time PCR (RT-PCR) is where a target-specific amplification signal becomes detectable and can infer viral load, risk of transmission and recovery. Use of Ct values in ... -
SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy
Laith J., Abu-Raddad; Chemaitelly, Hiam; Coyle, Peter; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; Younuskunju, Shameem; Ayoub, Houssein H.; Al Kanaani, Zaina; Al Kuwari, Einas; Butt, Adeel A.; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Nasrallah, Gheyath K.; Yassine, Hadi M.; Al Kuwari, Mohamed Ghaith; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al Khal, Abdullatif; Bertollini, Roberto... more authors ... less authors ( Elsevier , 2021 , Article)Background Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns. SARS-CoV-2 reinfections were assessed in a cohort of antibody-positive persons ... -
SARS-CoV-2 Infection Is at Herd Immunity in the Majority Segment of the Population of Qatar.
Al-Thani, Mohamed H; Farag, Elmoubasher; Bertollini, Roberto; Al Romaihi, Hamad Eid; Abdeen, Sami; Abdelkarim, Ashraf; Daraan, Faisal; Elhaj Ismail, Ahmed Ibrahim Hashim; Mostafa, Nahid; Sahl, Mohamed; Suliman, Jinan; Tayar, Elias; Kasem, Hasan Ali; Agsalog, Meynard J A; Akkarathodiyil, Bassam K; Alkhalaf, Ayat A; Alakshar, Mohamed Morhaf M H; Al-Qahtani, Abdulsalam Ali A H; Al-Shedifat, Monther H A; Ansari, Anas; Ataalla, Ahmad Ali; Chougule, Sandeep; Gopinathan, Abhilash K K V; Poolakundan, Feroz J; Ranbhise, Sanjay U; Saefan, Saed M A; Thaivalappil, Mohamed M; Thoyalil, Abubacker S; Umar, Inayath M; Al Kanaani, Zaina; Al Khal, Abdullatif; Al Kuwari, Einas; Butt, Adeel A; Coyle, Peter; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F; Yassine, Hadi M; Nasrallah, Gheyath K; Al Kuwari, Mohamed Ghaith; Chaghoury, Odette; Chemaitelly, Hiam; Abu-Raddad, Laith J... more authors ... less authors ( Oxford University Press , 2021 , Article)Qatar experienced a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic that disproportionately affected the craft and manual worker (CMW) population, who comprise 60% of the total population. This study ... -
SARS-CoV-2 seroprevalence in the urban population of Qatar: An analysis of antibody testing on a sample of 112,941 individuals
Peter V., Coyle; Chemaitelly, Hiam; Ben Hadj Kacem, Mohamed Ali; Abdulla Al Molawi, Naema Hassan; El Kahlout, Reham Awni; Gilliani, Imtiaz; Younes, Nourah; Al Anssari, Ghada Ali A.A.; Al Kanaani, Zaina; Al Khal, Abdullatif; Al Kuwari, Einas; Butt, Adeel A.; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Nasrallah, Gheyath K.; Yassine, Hadi M.; Al Kuwari, Mohamed Ghaith; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Elsevier , 2021 , Article)The study objective was to the assess level of detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the urban population of Qatar. Antibody testing was performed on residual blood specimens ... -
Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months
Laith J., Abu-Raddad; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; Younuskunju, Shameem; Al Kanaani, Zaina; Al Khal, Abdullatif; Al Kuwari, Einas; Butt, Adeel A.; Coyle, Peter; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Yassine, Hadi M.; Al Kuwari, Mohamed G.; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Bertollini, Roberto... more authors ... less authors ( Elsevier , 2021 , Article)We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ... -
Within-Host Diversity of SARS-CoV-2 in COVID-19 Patients With Variable Disease Severities.
Al Khatib, Hebah A; Benslimane, Fatiha M; Elbashir, Israa E; Coyle, Peter V; Al Maslamani, Muna A; Al-Khal, Abdullatif; Al Thani, Asmaa A; Yassine, Hadi M... more authors ... less authors ( Frontiers Media , 2020 , Article)The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients either are asymptomatic or have mild symptoms. Yet, about 15% of the cases experience ...