Browsing Biomedical Research Center Research by Publisher "Multidisciplinary Digital Publishing Institute (MDPI)"
Now showing items 1-20 of 30
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A Snapshot of Antimicrobial Resistance in Semi-Wild Oryx: Baseline Data from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background/Objectives: The spread of antimicrobial resistance (AMR) is a growing global health concern. Wild animals can play an important role in the amplification and dissemination of AMR and in conservation efforts ... -
Adipose-Derived Stromal Cells and Cancer-Associated Fibroblasts: Interactions and Implications in Tumor Progression
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Adipose-derived stromal cells (ASCs) and cancer-associated fibroblasts (CAFs) play pivotal roles in the tumor microenvironment (TME), significantly influencing cancer progression and metastasis. This review explores the ... -
Alterations in Choline Metabolism in Non-Obese Individuals with Insulin Resistance and Type 2 Diabetes Mellitus
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The prevalence of non-obese individuals with insulin resistance (IR) and type 2 diabetes (T2D) is increasing worldwide. This study investigates the metabolic signature of phospholipid-associated metabolites in non-obese ... -
Characterization of the Efficacy of a Split Swine Influenza A Virus Nasal Vaccine Formulated with a Nanoparticle/STING Agonist Combination Adjuvant in Conventional Pigs
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Swine influenza A viruses (SwIAVs) are pathogens of both veterinary and medical significance. Intranasal (IN) vaccination has the potential to reduce flu infection. We investigated the efficacy of split SwIAV H1N2 antigens ... -
Comparative Analysis of In Vitro Pumps Used in Cardiovascular Investigations: Focus on Flow Generation Principles and Characteristics of Generated Flows
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)A comprehensive analysis of in vitro pumps used in cardiovascular research is provided in this review, with a focus on the characteristics of generated flows and principles of flow generations. The cardiovascular system, ... -
Enhancing Influenza Detection through Integrative Machine Learning and Nasopharyngeal Metabolomic Profiling: A Comprehensive Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Background/Objectives: Nasal and nasopharyngeal swabs are commonly used for detecting respiratory viruses, including influenza, which significantly alters host cell metabolites. This study aimed to develop a machine learning ... -
Evaluating the Effects of BSA-Coated Gold Nanorods on Cell Migration Potential and Inflammatory Mediators in Human Dermal Fibroblasts
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Albumin-coated gold nanoparticles display potential biomedical applications, including cancer research, infection treatment, and wound healing; however, elucidating their interaction with normal cells remains an area with ... -
Evaluation of Efficacy of Surface Coated versus Encapsulated Influenza Antigens in Mannose–Chitosan Nanoparticle-Based Intranasal Vaccine in Swine
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)This study focuses on the development and characterization of an intranasal vaccine platform using adjuvanted nanoparticulate delivery of swine influenza A virus (SwIAV). The vaccine employed whole inactivated H1N2 SwIAV ... -
Exercise Metabolome: Insights for Health and Performance
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Exercise has many benefits for physical and mental well-being. Metabolomics research has allowed scientists to study the impact of exercise on the body by analyzing metabolites released by tissues such as skeletal muscle, ... -
Functional Characterization of Novel MC4R Variants Identified in Two Unrelated Patients with Morbid Obesity in Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)The leptin–melanocortin pathway is pivotal in appetite and energy homeostasis. Pathogenic variants in genes involved in this pathway lead to severe early-onset monogenic obesity (MO). The MC4R gene plays a central role in ... -
Generation of Novel Tumour-Selective SEA Superantigen-Based Peptides with Improved Safety and Efficacy for Precision Cancer Immunotherapy
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Bacterial superantigens are T-cell-stimulatory protein molecules which produce massive cytokines and cause human diseases. Due to their ability to activate up to 20% of resting T-cells, they have effectively killed ... -
gnas Knockdown Induces Obesity and AHO Features in Early Zebrafish Larvae
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)GNAS (Guanine Nucleotide-Binding Protein, Alpha Stimulating) is a complex gene that encodes the alpha subunit of the stimulatory G protein (Gsα), critical for signaling through various G protein-coupled receptors. Inactivating ... -
Identification of KSR2 Variants in Pediatric Patients with Severe Early-Onset Obesity from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)The kinase suppressor of Ras 2 (KSR2) gene is associated with monogenic obesity, and loss-of-function variants in KSR2 have been identified in individuals with severe early-onset obesity. This study investigated KSR2 ... -
The impact of microbial composition on postprandial glycaemia and lipidaemia: A systematic review of current evidence
( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Postprandial hyperglycaemia is associated with increased risk of cardiovascular disease. Recent studies highlight the role of the gut microbiome in influencing postprandial glycaemic (PPG) and lipidaemic (PPL) responses. ... -
Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular Targets
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)Obesity, characterized by excessive body fat, is closely linked to endoplasmic reticulum (ER) stress, leading to insulin resistance and type 2 diabetes. Inflammatory pathways like c-Jun N-terminal kinase (JNK) worsen insulin ... -
Indoleacetylglutamine Pathway Is a Potential Biomarker for Cardiovascular Diseases
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality. Metabolomics allows for the identification of important biomarkers for CVDs, essential for early detection and risk assessment. This ... -
Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ... -
Latest Developments in Adapting Deep Learning for Assessing TAVR Procedures and Outcomes
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Aortic valve defects are among the most prevalent clinical conditions. A severely damaged or non-functioning aortic valve is commonly replaced with a bioprosthetic heart valve (BHV) via the transcatheter aortic valve ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1? Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Melatonin Ameliorates Organellar Calcium Homeostasis, Improving Endoplasmic Reticulum Stress-Mediated Apoptosis in the Vastus Lateralis Muscle of Both Sexes of Obese Diabetic Rats
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)Endoplasmic reticulum (ER) stress is a crucial factor in the progression of obesity-related type 2 diabetes (diabesity), contributing to skeletal muscle (SKM) dysfunction, calcium imbalance, metabolic inflexibility, and ...
