Biomedical Research Center Research: Recent submissions
Now showing items 1-20 of 808
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Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders
( Frontiers Media , 2022 , Article)The ryanodine receptor (RyR) is a homotetrameric channel mediating sarcoplasmic reticulum Ca<sup>2+</sup> release required for skeletal and cardiac muscle contraction. Mutations in RyR1 and RyR2 lead to life-threatening ... -
Disparate molecular mechanisms in cardiac ryanodine receptor channelopathies
( Frontiers Media , 2024 , Article)Aims: Mutations in the cardiac ryanodine receptor (RyR2) are associated with catecholaminergic polymorphic ventricular tachycardia (CPVT). This study investigates the underlying molecular mechanisms for CPVT mutations ... -
Centrifugal and Solution Blow Spinning Techniques in Tissue Engineering
( Bentham Science Publishers , 2024 , Book chapter)Nanofibers are a necessary source for fibrous materials and other useful applications such as tissue engineering, filtration, safety fabrics, batteries for the production of nanofibers so far. However, due to its low ... -
Exploring the link between environmental chemical exposures and epigenetic modifications in diabetes mellitus.
( The Association of Basic Medical Sciences , 2025 , Article Review)Diabetes mellitus (DM) is a globally prevalent metabolic disorder characterized by impaired glucose homeostasis and insulin secretion. Beyond traditional risk factors like lifestyle and genetics, environmental pollutants, ... -
Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity
( Microbiology Society , 2025 , Article)Introduction. Pre-existing immunity to human coronaviruses (HCoVs) may shape the immune response in COVID-19 patients. Increasing evidence suggests that immune cross-reactivity between SARS-CoV-2 and other coronaviruses ... -
Antibody-dependent enhancement of SARS-CoV-2, the impact of variants and vaccination
( Taylor and Francis Group , 2025 , Article)This study characterized antibody-dependent enhancement (ADE) in serum samples from individuals exposed to SARS-CoV-2 via infection or vaccination and evaluated its association with SARS-CoV-2 variants (Wuhan and Omicron), ... -
The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages
( Microbiology Society , 2025 , Article)The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced ... -
Glucosamine Schiff bases as fluorescent sensors for recognition of Al+3 and Zn+2 ions
( Elsevier , 2025 , Article)Glucosamine salicylidene (GAS) and Glucosamine-4-nitrosalicylidene (GANS) were synthesized using microwave and investigated as water-soluble chemosensors for aluminum and zinc ions. UV–vis, fluorescence titration, binding ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1? Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Protection conferred by SARS-CoV-2 infection across a spectrum of reinfection symptoms and severities
( BMJ Publishing Group , 2025 , Article)Background SARS-CoV-2 infection is associated with protection against reinfection. This study analysed this protection across different reinfection symptoms and severities, comparing the preomicron and omicron eras. Methods ... -
N-Lactoyl amino acids as metabolic biomarkers differentiating low and high exercise response
( Institute of Sport , 2025 , Article)Aerobic physical exercise has significant benefits for cardiovascular health; however, some individuals experience no benefit or even adverse effects. One reason for poor tolerance to aerobic exercise may be a low percentage ... -
A Snapshot of Antimicrobial Resistance in Semi-Wild Oryx: Baseline Data from Qatar
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background/Objectives: The spread of antimicrobial resistance (AMR) is a growing global health concern. Wild animals can play an important role in the amplification and dissemination of AMR and in conservation efforts ... -
Accre 8 emerging point of care CLIA system for vitamin B12 assessment compared with three established assays
( Nature Research , 2025 , Article)Accurate Vitamin B12 (Vit B12) quantification is essential for diagnosing deficiencies linked to neurological and hematological disorders. The Accre 8 Point-of-Care (POC) Chemiluminescent Immunoassay (CLIA) system offers ... -
Indoleacetylglutamine Pathway Is a Potential Biomarker for Cardiovascular Diseases
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality. Metabolomics allows for the identification of important biomarkers for CVDs, essential for early detection and risk assessment. This ... -
Silicone Quaterium-22 Surfactant as an Eco-Friendly Carbon Steel Anticorrosive: Assessment of Corrosion Inhibition Properties and Ecotoxicity in Zebrafish Embryos
( Elsevier , 2025 , Article)Corrosion of carbon steel pipelines in the oil and gas industry presents operational and environmental challenges, requiring safer alternatives to toxic corrosion inhibitors. This study evaluates Silicon-Q-22 (SQ22) as a ... -
Optimization of UAE of phenolic and antioxidant compounds from Ephedra foeminea by RSM
( Qatar University , 2025 , Poster)Ephedra foeminea Forssk, a widely distributed shrub in the East Mediterranean, possesses numerous traditional medicinal applications and is an abundant source of bioactive phytochemical metabolites. In this study, ult ... -
Utilization of Complementary Medicine Among Type 2 Diabetes Patients in Qatar: A Cross Sectional Study
( Elsevier , 2025 , Article)BackgroundDiabetes Mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to inadequate insulin production or ineffective insulin utilization. The prevalence of DM is rising globally, ... -
Phytochemical Composition and Anticancer Properties of Haplophyllum tuberculatum Growing in Qatar and Oman Against Human Triple-Negative Breast Cancer Cells
( Qatar University , 2025 , Poster)Introduction: Breast cancer ranks as the most frequently diagnosed cancer globally, with the triple-negative breast cancer (TNBC) subtype linked to a notably poor prognosis. The absence of optimal therapeutic regimens ... -
Developmental toxicity of Peganum harmala seed extractsin zebrafish embryos
( Qatar University , 2025 , Poster)Introduction: Peganum harmala L. is a widely utilized plant in traditional medicine in many countries, including Qatar. Nevertheless, there have been several reports of toxic effects associated with the use of P. harmala ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1α Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( MDPI , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ...
