Biomedical Research Center Research: Recent submissions

Now showing items 261-280 of 738

    • Introduction and expansion of the SARS-CoV-2 B.1.1.7 variant and reinfections in Qatar: A nationally representative cohort study 

      J. Abu-Raddad, Laith; Chemaitelly, Hiam; H. Ayoub, Houssein; Coyle, Peter; A. Malek, Joel; ... more authors ( Public Library of Science , 2021 , Article)
      Background The epidemiology of the SARS-CoV-2 B.1.1.7 (or Alpha) variant is insufficiently understood. This study’s objective was to describe the introduction and expansion of this variant in Qatar and to estimate the ...

    • Reporting of RT-PCR cycle threshold (Ct) values during the first wave of COVID-19 in Qatar improved result interpretation in clinical and public health settings 

      V. Coyle, Peter; Hassan Al Molawi, Naema; Ali Ben Hadj Kacem, Mohamed; Awni El Kahlout, Reham; Al Kuwari, Einas; ... more authors ( Microbiology Society , 2022 , Article)
      Introduction. The cycle threshold (Ct) value in real-time PCR (RT-PCR) is where a target-specific amplification signal becomes detectable and can infer viral load, risk of transmission and recovery. Use of Ct values in ...

    • Assessing the performance of a serological point-of-care test in measuring detectable antibodies against SARS-CoV-2 

      El Kahlout, Reham Awni; Coyle, Peter V.; Dargham, Soha R.; Chemaitelly, Hiam; Kacem, Mohamed Ali Ben Hadj; ... more authors ( Public Library of Science , 2022 , Article)
      This study investigated the performance of a rapid point-of-care antibody test, the BioMedomics COVID-19 IgM/IgG Rapid Test, in comparison with a high-quality, validated, laboratory-based platform, the Roche Elecsys ...

    • COVID-19 risk score as a public health tool to guide targeted testing: A demonstration study in Qatar 

      J. Abu-Raddad, Laith; Dargham, Soha; Chemaitelly, Hiam; Coyle, Peter; Al Kanaani, Zaina; ... more authors ( Public Library of Science , 2022 , Article)
      We developed a Coronavirus Disease 2019 (COVID-19) risk score to guide targeted RTPCR testing in Qatar. The Qatar national COVID-19 testing database, encompassing a total of 2,688,232 RT-PCR tests conducted between February ...

    • Effectiveness of mRNA booster doses against the omicron variant 

      Hadeel T, Zedan; Nasrallah, Gheyath K ( Elsevier , 2022 , Article)
      Since its emergence in November, 2021, the omicron (B.1.1.529) variant of SARS-CoV-2 has rapidly spread and quickly overtaken the delta (B.1.617.2) variant as the most common cause of infection.1 Due to numerous spike ...

    • Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model 

      Zakaria, Zain Z; Mahmoud, Nouf N; Benslimane, Fatiha M; Yalcin, Huseyin C.; Al Moustafa, Ala-Eddin; ... more authors ( American Chemical Society , 2022 , Article)
      Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ...

    • Impacts on Student Learning and Skills and Implementation Challenges of Two Student-Centered Learning Methods Applied in Online Education 

      soubra, lama; al Ghouti, Mohamed; Abu diyeh, Mohamed; Crovella, sergio; Abou saleh, Haissam ( MDPI , 2022 , Article)
      Online education became more prevalent during the COVID-19 pandemic in many countries around the world, including the Gulf Cooperation Council (GCC) countries. This study aims at assessing the impacts on learning and skills ...

    • Ziziphus nummularia: A Comprehensive Review of Its Phytochemical Constituents and Pharmacological Properties 

      Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Maresca, Marc; Shaito, Abdullah; ... more authors ( MDPI , 2022 , Article Review)
      Ziziphus nummularia, a small bush of the Rhamnaceae family, has been widely used in traditional folk medicine, is rich in bioactive molecules, and has many reported pharmacological and therapeutic properties. Objective: ...

    • Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells 

      AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; ... more authors ( Frontiers Media , 2022 , Article)
      Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ...

    • Design and Microinjection of Morpholino Antisense Oligonucleotides and mRNA into Zebrafish Embryos to Elucidate Specific Gene Function in Heart Development 

      Zakaria, Zain Zaki; Eisa-Beygi, Shahram; Benslimane, Fatiha; Ramchandran4, Ramani; Yalcin, Huseyin C. ( MyJove Corporation , 2022 , Article)
      The morpholino oligomer-based knockdown system has been used to identify the function of various gene products through loss or reduced expression. Morpholinos (MOs) have the advantage in biological stability over DNA oligos ...

    • Elevated Adipsin and Reduced C5a Levels in the Maternal Serum and Follicular Fluid During Implantation Are Associated With Successful Pregnancy in Obese Women 

      Ramanjaneya, Manjunath; Diboun, Ilhame; Rizwana, Najeha; Dajani, Yaser; Ahmed, Lina; ... more authors ( Frontiers Media , 2022 , Article)
      Introduction: Complement factors mediate the recruitment and activation of immune cells and are associated with metabolic changes during pregnancy. The aim of this study was to determine whether complement factors in the ...

    • Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; ... more authors ( Nature Research , 2022 , Article)
      There is significant genetic distance between SARS-CoV-2 Omicron (B.1.1.529) variant BA.1 and BA.2 sub-lineages. This study investigates immune protection of infection with one sub-lineage against reinfection with the other ...

    • A highly sensitive wearable pressure sensor capsule based on PVA/Mxene composite gel 

      Kallingal, Nithusha; Maurya, Muni Raj; Sajna, M. S.; Yalcin, Huseyin Cagatay; Ouakad, Hassen M.; ... more authors ( Springer , 2022 , Article)
      Wearable sensors have drawn considerable interest in the recent research world. However, simultaneously realizing high sensitivity and wide detection limits under changing surrounding environment conditions remains ...

    • Implications of Gut Microbiota in Epithelial–Mesenchymal Transition and Cancer Progression: A Concise Review 

      Gupta, Ishita; Pedersen, Shona; Vranic, Semir; Al Moustafa, Ala Eddin ( MDPI , 2022 , Article Review)
      Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial– mesenchymal transition (EMT) event. ...

    • Effects of Previous Infection and Vaccination on Symptomatic Omicron Infections. 

      Altarawneh, Heba N; Chemaitelly, Hiam; Ayoub, Houssein H; Tang, Patrick; Hasan, Mohammad R; ... more authors ( Massachusetts Medical Society , 2022 , Article)
      The protection conferred by natural immunity, vaccination, and both against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with the BA.1 or BA.2 sublineages of the omicron (B.1.1.529) ...

    • Protection against the omicron variant from previous SARS-CoV-2 infection 

      Altarawneh, Heba N.; Chemaitelly, Hiam; Hasan, Mohammad R.; Ayoub, Houssein H.; Qassim, Suelen; ... more authors ( Massachusetts Medical Society , 2022 , Other)
      Natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits strong protection against reinfection with the B.1.1.7 (alpha),1,2 B.1.351 (beta),1 and B.1.617.2 (delta)3 variants. However, the ...

    • Will Host Genetics Affect the Response to SARS-CoV-2 Vaccines? Historical Precedents 

      Smatti, Maria K.; Alkhatib, Hebah A.; Al Thani, Asmaa A.; Yassine, Hadi M. ( Frontiers Media , 2022 , Article Review)
      Recent progress in genomics and bioinformatics technologies have allowed for the emergence of immunogenomics field. This intersection of immunology and genetics has broadened our understanding of how the immune system ...

    • Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines 

      Fernandes, Queenie; Inchakalody, Varghese Philipose; Merhi, Maysaloun; Mestiri, Sarra; Taib, Nassiba; ... more authors ( Taylor and Francis , 2022 , Article)
      The emergence of novel and evolving variants of SARS-CoV-2 has fostered the need for change in the form of newer and more adaptive diagnostic methods for the detection of SARS-CoV-2 infections. On the other hand, developing ...

    • Editorial: OMICS-Based Approaches in Sports Research. 

      Elrayess, Mohamed A; Botrè, Francesco; Palermo, Amelia ( Frontiers Media , 2022 , Article)
      Genomics, transcriptomics and metabolomics are increasingly generating key insights for the development of precision approaches in heath and disease. Omics technologies have unlocked the high-throughput discovery of ...

    • Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar. 

      Chemaitelly, Hiam; Ayoub, Houssein H; AlMukdad, Sawsan; Coyle, Peter; Tang, Patrick; ... more authors ( Nature Research , 2022 , Article)
      SARS-CoV-2 Omicron BA.1 and BA.2 subvariants are genetically divergent. We conducted a matched, test-negative, case-control study to estimate duration of protection of the second and third/booster doses of mRNA COVID-19 ...