Biomedical Research Center Research: Recent submissions

Now showing items 321-340 of 708

    • Reinfections in COVID-19 Patients: Impact of Virus Genetic Variability and Host Immunity 

      Fakhroo, Aisha; AlKhatib, Hebah A; Al Thani, Asmaa A; Yassine, Hadi M ( MDPI , 2021 , Article)
      The COVID-19 pandemic is still posing a devastating threat to social life and economics. Despite the modest decrease in the number of cases during September-November 2020, the number of active cases is on the rise again. ...

    • Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities 

      Wehbe, Zena; Wehbe, Maya; Iratni, Rabah; Pintus, Gianfranco; Zaraket, Hassan; ... more authors ( Frontiers Media , 2021 , Article)
      As of January 2021, SARS-CoV-2 has killed over 2 million individuals across the world. As such, there is an urgent need for vaccines and therapeutics to reduce the burden of COVID-19. Several vaccines, including mRNA, ...

    • Epidemiology of SARS-CoV2 in Qatar's primary care population aged 10 years and above 

      Syed, Mohamed Ahmed; Al Nuaimi, Ahmed Sameer; A/Qotba, Hamda Abdulla; Nasrallah, Gheyath K; Althani, Asmaa A; ... more authors ( BMC , 2021 , Article)
      There is an urgent need to elucidate the epidemiology of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) and characterize its potential impact. Investing in characterising the SARS-CoV2 will help plan and ...

    • Effect of Water-Pipe Smoking on the Normal Development of Zebrafish 

      Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; ... more authors ( MDPI , 2021 , Article)
      Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ...

    • BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar. 

      Tang, Patrick; Hasan, Mohammad R; Chemaitelly, Hiam; Yassine, Hadi M; Benslimane, Fatiha M; ... more authors ( Nature Researc , 2021 , Article)
      With the global expansion of the highly transmissible SARS-CoV-2 Delta (B.1.617.2) variant, we conducted a matched test-negative case-control study to assess the real-world effectiveness of COVID-19 messenger RNA vaccines ...

    • Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar. 

      Abu-Raddad, Laith J; Chemaitelly, Hiam; Ayoub, Houssein H; Yassine, Hadi M; Benslimane, Fatiha M; ... more authors ( American Medical Association , 2021 , Article)
      The effect of prior SARS-CoV-2 infection on vaccine protection remains poorly understood. To assess protection from SARS-CoV-2 breakthrough infection after mRNA vaccination among persons with vs without prior SARS-CoV-2 ...

    • Real-Time SARS-CoV-2 Genotyping by High-Throughput Multiplex PCR Reveals the Epidemiology of the Variants of Concern in Qatar 

      R. Hasan, Mohammad; K.R. Kalikiri, Mahesh; Mirza, Faheem; Sundararaju, Sathyavathi; Sharma, Anju; ... more authors ( Elsevier , 2021 , Article)
      Complementing whole genome sequencing strategies with high-throughput multiplex RT-qPCR genotyping allows for more comprehensive and real-time tracking of SARS-CoV-2 variants of concern. During the second and third waves ...

    • Screening the growth inhibition mechanism of sulfate reducing bacteria by chitosan/lignosulfonate nanocomposite (CS@LS) in seawater media 

      Kashif, Rasool; Pandey, Ravi P.; Rasheed, P. Abdul; Gomez, Tricia; Al-Absi, Enas S.; ... more authors ( Elsevier , 2021 , Article)
      Sulfate-reducing bacteria (SRBs) induced biofilm formation is a global industrial concern due to its role in the development of microbial-induced corrosion (MIC). Herein, we have developed a biodegradable chitosan/lignosulfonate ...

    • Editorial: Unconventional Animal Models in Infectious Disease Research 

      Kamareddine, Layla ( Frontiers Media , 2021 , Other)
      Beyond an in vitro setting, the use of a biological system is considered imperious to unravel the enigma of host-pathogen interactions, particularly those eventuating in an infectious disease scenery. In the past two-decades, ...

    • The effect of surface-modified gold nanorods on the early stage of embryonic development and angiogenesis: Insight into the molecular pathways 

      Mahmoud, Nouf N.; Zakaria, Zain Zaki; Kheraldine, Hadeel; Gupta, Ishita; Vranic, Semir; ... more authors ( MDPI , 2021 , Article)
      Gold nanorods have been implicated in several biomedical applications. Herein, the effect of two surface-modified gold nanorods on the early stages of embryogenesis and angiogenesis was investigated using avian embryos at ...

    • Emerging innate biological properties of nano-drug delivery systems: A focus on PAMAM dendrimers and their clinical potential 

      Kheraldine, Hadeel; Rachid, Ousama; M Habib, Abdella; Al Moustafa, Ala-Eddin; F. Benter, Ibrahim ( Elsevier , 2021 , Article)
      Drug delivery systems or vectors are usually needed to improve the bioavailability and effectiveness of a drug through improving its pharmacokinetics/pharmacodynamics at an organ, tissue or cellular level. However, emerging ...

    • Bio-vehicles of cytotoxic drugs for delivery to tumor specific targets for cancer precision therapy 

      Layla, Al-mansoori; Elsinga, Philip; Goda, Sayed K. ( Elsevier , 2021 , Article Review)
      Abnormal structural and molecular changes in malignant tissues were thoroughly investigated and utilized to target tumor cells, hence rescuing normal healthy tissues and lowering the unwanted side effects as non-specific ...

    • High Endurance Elite Athletes Show Age-dependent Lower Levels of Circulating Complements Compared to Low/Moderate Endurance Elite Athletes 

      Al-Muraikhy, S.; Al-Muraikhy, Shamma; Ramanjaneya, Manjunath; Dömling, Alexander S.; Bettahi, Ilham; ... more authors ( Frontiers Media , 2021 , Article)
      Introduction: Aerobic exercise activates the complement system in the peripheral blood. However, the effect of age and high intensity endurance training on the levels of circulating complements and sassociated inflammatory ...

    • Investigation of the effect of anticoagulant usage in the flow diverter stent treatment of the patient-specific cerebral aneurysm using the Lagrangian coherent structures 

      Muhammed Furkan, Tercanlı; Olcay, Ali Bahadır; Mutlu, Onur; Bilgin, Cem; Hakyemez, Bahattin ( Elsevier , 2021 , Article)
      Anticoagulants are prescribed to the flow diverter treated patients to diminish the risk of embolism in the arteries. In the present study, digital subtraction angiography images of a 49-year-old female patient with a left ...

    • A review of smart sensors coupled with Internet of Things and Artificial Intelligence approach for heart failure monitoring 

      Maurya, Muni Raj; Riyaz, Najam U.S.Sahar; Reddy, M. Sai Bhargava; Yalcin, Huseyin Cagatay; Ouakad, Hassen M.; ... more authors ( Springer Nature , 2021 , Article)
      Over the last decade, there has been a huge demand for health care technologies such as sensors-based prediction using digital health. With the continuous rise in the human population, these technologies showed to be ...

    • SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy 

      Laith J., Abu-Raddad; Chemaitelly, Hiam; Coyle, Peter; Malek, Joel A.; Ahmed, Ayeda A.; ... more authors ( Elsevier , 2021 , Article)
      Background Reinfection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been documented, raising public health concerns. SARS-CoV-2 reinfections were assessed in a cohort of antibody-positive persons ...

    • mRNA-1273 COVID-19 vaccine effectiveness against the B.1.1.7 and B.1.351 variants and severe COVID-19 disease in Qatar 

      Chemaitelly, Hiam; Yassine, Hadi M.; Benslimane, Fatiha M.; Al Khatib, Hebah A.; Tang, Patrick; ... more authors (2021 , Article)
      The SARS-CoV-2 pandemic continues to be a global health concern. The mRNA-1273 (Moderna) vaccine was reported to have an efficacy of 94.1% at preventing symptomatic COVID-19 due to infection with ‘wild-type’ variants in a ...

    • Epidemiological impact of prioritising SARS-CoV-2 vaccination by antibody status: Mathematical modelling analyses 

      Ayoub, H.H.; Ayoub, Houssein H.; Chemaitelly, Hiam; Makhoul, Monia; Al Kanaani, Zaina; ... more authors ( BMJ Publishing Group , 2021 , Article)
      Background Vaccines against SARS-CoV-2 have been developed, but their availability falls far short of global needs. This study aimed to investigate the impact of prioritising available doses on the basis of recipient ...

    • SARS-CoV-2 seroprevalence in the urban population of Qatar: An analysis of antibody testing on a sample of 112,941 individuals 

      Peter V., Coyle; Chemaitelly, Hiam; Ben Hadj Kacem, Mohamed Ali; Abdulla Al Molawi, Naema Hassan; El Kahlout, Reham Awni; ... more authors ( Elsevier , 2021 , Article)
      The study objective was to the assess level of detectable severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the urban population of Qatar. Antibody testing was performed on residual blood specimens ...

    • SARS-CoV-2 Infection Is at Herd Immunity in the Majority Segment of the Population of Qatar. 

      Al-Thani, Mohamed H; Farag, Elmoubasher; Bertollini, Roberto; Al Romaihi, Hamad Eid; Abdeen, Sami; ... more authors ( Oxford University Press , 2021 , Article)
      Qatar experienced a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic that disproportionately affected the craft and manual worker (CMW) population, who comprise 60% of the total population. This study ...