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    Haematococcus pluvialis Microalgae Extract Inhibits Proliferation, Invasion, and Induces Apoptosis in Breast Cancer Cells

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    Date
    2022
    Author
    Alateyah, Nouralhuda
    Ahmad, Salma M. S.
    Gupta, Ishita
    Fouzat, Arij
    Thaher, Mahmoud Ibrahim
    Das, Probir
    Al Moustafa, Ala-Eddin
    Ouhtit, Allal
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    Abstract
    Breast cancer (BC) is the most common malignant cancer in females worldwide. Drug resistance, toxicity, and the failure of current therapies to completely cure BC has challenged conventional medicine. Consequently, complementary alternative medicine has become popular due to its safety and efficacy. Haematococcus pluvialis (H. pulvialis) is a green microalga living in fresh water, and its crude extract is rich of bioactives, including carotenoids, known to inhibit cancer cell growth. In the present study, we investigated the effects of a methanol crude extract called "T1" of H. pulvialis on cell growth and migration/invasion of the BC cell line MDA-MB-231 in comparison to the fibroblast control cells. TI significantly suppressed BC cell growth, inhibited migration and invasion and induced apoptosis. Interestingly, apoptosis was mediated by a significant loss of mutant p53 protein, and increased Bax/Bcl2 ratio. Our findings support our hypothesis that T1 exerts its anti-cancer effects by inhibiting BC invasion and inducing apoptosis mediated, at least, via the p53/Bax/Bcl2 pathway. Ongoing experiments aim to identify the molecular mechanisms underpinning T1-inhibited BC cell invasion using pre-designed metastasis gene-based array method.
    DOI/handle
    http://dx.doi.org/10.3389/fnut.2022.882956
    http://hdl.handle.net/10576/38683
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    • Biological & Environmental Sciences [‎660‎ items ]
    • Biomedical Research Center Research [‎537‎ items ]
    • Medicine Research [‎732‎ items ]
    • Pharmacy Research [‎820‎ items ]

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