Biomedical Research Center Research: Recent submissions

Now showing items 461-480 of 738

    • The Effects of Gum Acacia on the Composition of the Gut Microbiome and Plasma Levels of Short-Chain Fatty Acids in a Rat Model of Chronic Kidney Disease 

      Al-Asmakh, Maha; Sohail, Muhammad Umar; Al-Jamal, Ola; Shoair, Banan Mosaad; Al-Baniali, Asmaa Yousef; ... more authors ( Frontiers Media , 2020 , Article)
      Chronic kidney disease (CKD) may be fatal for its victims and is an important long-term public health problem. The complicated medical procedures and diet restrictions to which patients with CKD are subjected alter the gut ...

    • Epidemiological, molecular, and clinical features of rotavirus infections among pediatrics in Qatar 

      Mathew, Shilu; Al Ansari, Khalid; Al Thani, Asmaa A; Zaraket, Hassan; Yassine, Hadi M ( Springer , 2021 , Article)
      Acute gastroenteritis (AGE) remains a major cause of diarrhea in developing and developed countries. Rotavirus (RV) is a leading cause of severe pediatric diarrhea worldwide. Here we report on the prevalence of circulating ...

    • Platforms Exploited for SARS-CoV-2 Vaccine Development. 

      Mathew, Shilu; Faheem, Muhammed; Hassain, Neeraja A; Benslimane, Fatiha M; Thani, Asmaa A Al; ... more authors ( MDPI , 2020 , Article Review)
      The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only zoonotic-origin coronavirus (CoV) that has reached the pandemic stage. The virus uses its spike (S) glycoprotein to attach to the host cells ...

    • Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype. 

      Allouch, Soumaya; Gupta, Ishita; Malik, Shaza; Al Farsi, Halema F; Vranic, Semir; ... more authors ( Frontiers Media , 2020 , Article)
      Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular, gestational breast cancer is considered one of the most aggressive types of cancers, which is a rare but fatal disease. However, the ...

    • Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months 

      Laith J., Abu-Raddad; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; ... more authors ( Elsevier , 2021 , Article)
      We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ...

    • Advances in Cardiovascular Biomarker Discovery. 

      Ghantous, Crystal M; Kamareddine, Layla; Farhat, Rima; Zouein, Fouad A; Mondello, Stefania; ... more authors ( MDPI , 2020 , Article Review)
      Cardiovascular diseases are the leading causes of mortality worldwide. Among them, hypertension and its pathological complications pose a major risk for the development of other cardiovascular diseases, including heart ...

    • Seroprevalence of West Nile Virus among Healthy Blood Donors from Different National Populations Residing in Qatar 

      Soha R., Dargham; Al-Sadeq, Duaa W.; Yassine, Hadi M.; Ahmed, Muna; Kunhipurayil, Hasna; ... more authors ( Elsevier , 2020 , Article)
      ObjectiveTo estimate the age- and nationality-specific West Nile virus (WNV) seroprevalence in select Middle East and North Africa (MENA) populations residing in Qatar. MethodsSera were collected from male blood donors ...

    • Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines 

      Sohail, Muhammad U.; Al-Mansoori, Layla; Al-Jaber, Hend; Georgakopoulos, Costas; Donati, Francesco; ... more authors ( Frontiers Media , 2020 , Article)
      © Copyright © 2020 Sohail, Al-Mansoori, Al-Jaber, Georgakopoulos, Donati, Botrè, Sellami and Elrayess. Objectives: Circulating cytokines and oxidative stress markers vary in response to different exercise regimens. This ...

    • Host Genetic Variants Potentially Associated With SARS-CoV-2: A Multi-Population Analysis. 

      Smatti, Maria K; Al-Sarraj, Yasser A; Albagha, Omar; Yassine, Hadi M ( Frontiers Media , 2020 , Article)
      Clinical outcomes of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) showed enormous inter-individual and inter-population differences, possibly due to host ...

    • Within-Host Diversity of SARS-CoV-2 in COVID-19 Patients With Variable Disease Severities. 

      Al Khatib, Hebah A; Benslimane, Fatiha M; Elbashir, Israa E; Coyle, Peter V; Al Maslamani, Muna A; ... more authors ( Frontiers Media , 2020 , Article)
      The ongoing pandemic of SARS-COV-2 has already infected more than eight million people worldwide. The majority of COVID-19 patients either are asymptomatic or have mild symptoms. Yet, about 15% of the cases experience ...

    • Immune Modulatory Effects of Vitamin D on Viral Infections. 

      Siddiqui, Maheen; Manansala, Judhell S; Abdulrahman, Hana A; Nasrallah, Gheyath K; Smatti, Maria K; ... more authors ( MDPI , 2020 , Article)
      Viral infections have been a cause of mortality for several centuries and continue to endanger the lives of many, specifically of the younger population. Vitamin D has long been recognized as a crucial element to the ...

    • Seasonality of Respiratory Viral Infections: Will COVID-19 Follow Suit? 

      Audi, Amani; AlIbrahim, Malak; Kaddoura, Malak; Hijazi, Ghina; Yassine, Hadi M; ... more authors ( Frontiers Media , 2020 , Article Review)
      Respiratory viruses, including coronaviruses, are known to have a high incidence of infection during winter, especially in temperate regions. Dry and cold conditions during winter are the major drivers for increased ...

    • Rapid Antibody-Based COVID-19 Mass Surveillance: Relevance, Challenges, and Prospects in a Pandemic and Post-Pandemic World. 

      Augustine, Robin; Das, Suvarthi; Hasan, Anwarul; S, Abhilash; Abdul Salam, Shaheen; ... more authors ( MDPI , 2020 , Article Review)
      The aggressive outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) as COVID-19 (coronavirus disease-2019) pandemic demands rapid and simplified testing tools for its effective management. Increased ...

    • Performance evaluation of five ELISA kits for detecting anti-SARS-COV-2 IgG antibodies 

      Hadi M., Yassine; Al-Jighefee, Hadeel; Al-Sadeq, Duaa W.; Dargham, Soha R.; Younes, Salma N.; ... more authors ( Elsevier , 2020 , Article)
      ObjectivesTo evaluate and compare the performances of five commercial ELISA assays (EDI, AnshLabs, Dia.Pro, NovaTec, and Lionex) for detecting anti-SARS-CoV-2 IgG. Methods70 negative control samples (collected before the ...

    • Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids. 

      Diboun, Ilhame; Al-Mansoori, Layla; Al-Jaber, Hend; Albagha, Omar; Elrayess, Mohamed A ( Endocrine Society , 2020 , Article)
      The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ...

    • Growth factor loaded in situ photocrosslinkable poly(3-hydroxybutyrate-co-3-hydroxyvalerate)/gelatin methacryloyl hybrid patch for diabetic wound healing 

      Augustine, Robin; Hasan, Anwarul; Dalvi, Yogesh B.; Rehman, Syed Raza Ur; Varghese, Ruby; ... more authors ( Elsevier , 2021 , Article)
      © 2020 The Authors Management of chronic diabetic ulcers remains as a major challenge in healthcare which requires extensive multidisciplinary approaches to ensure wound protection, management of excess wound exudates and ...

    • Application of a flow-induced stress wave and investigation of associated injuries on cell monolayers using a parallel plate flow chamber 

      Shurbaji, Samar; Al-Ruweidi, Mahmoud Khatib A.A.; Ali, Fatma Hassan; Benslimane, Fatiha M.; Yalcin, Huseyin C. ( MDPI , 2020 , Article)
      © 2020 by the authors. Licensee MDPI, Basel, Switzerland. Parallel plate flow chambers are widely used to expose cultured cells to physiological flows for the investigation of a variety of diseases. These applications ...

    • Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model 

      Da'as, Sahar I.; Yalcin, Huseyin C.; Nasrallah, Gheyath K.; Mohamed, Iman A.; Nomikos, Michail; ... more authors ( Wiley , 2020 , Article)
      © 2020 Wiley Periodicals, Inc. Myosin-binding protein C 3 (MYBPC3) variants are the most common cause of hypertrophic cardiomyopathy (HCM). HCM is a complex cardiac disorder due to its significant genetic and clinical ...

    • A Global Declaration on Appropriate Use of Antimicrobial Agents across the Surgical Pathway 

      Sartelli, Massimo; Kluger, Yoram; Ansaloni, Luca; Carlet, Jean; Brink, Adrian; ... more authors ( Mary Ann Liebert Inc. , 2017 , Article)
      This declaration, signed by an interdisciplinary task force of 234 experts from 83 different countries with different backgrounds, highlights the threat posed by antimicrobial resistance and the need for appropriate use ...

    • Calreticulin regulates Src kinase in osteogenic differentiation from embryonic stem cells 

      Zahra, Alvandi; Al-Mansoori, Layla J.R; Opas, Michal ( Elsevier , 2020 , Article)
      Calreticulin, the major Ca2+ buffer of the endoplasmic reticulum plays an important role in the choice of fate by embryonic stem cells. Using the embryoid body method of organogenesis, we showed impaired osteogenesis in ...