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المؤلفHammoud, Safaa H.
المؤلفAlZaim, Ibrahim
المؤلفAl-Dhaheri, Yusra
المؤلفEid, Ali H.
المؤلفEl-Yazbi, Ahmed F.
تاريخ الإتاحة2023-07-31T05:51:52Z
تاريخ النشر2021-08-02
اسم المنشورFrontiers in Endocrinology
المعرّفhttp://dx.doi.org/10.3389/fendo.2021.707126
الاقتباسHammoud, S. H., AlZaim, I., Al-Dhaheri, Y., Eid, A. H., & El-Yazbi, A. F. (2021). Perirenal adipose tissue inflammation: novel insights linking metabolic dysfunction to renal diseases. Frontiers in Endocrinology, 12, 707126.
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85112782066&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/46416
الملخصA healthy adipose tissue (AT) is indispensable to human wellbeing. Among other roles, it contributes to energy homeostasis and provides insulation for internal organs. Adipocytes were previously thought to be a passive store of excess calories, however this view evolved to include an endocrine role. Adipose tissue was shown to synthesize and secrete adipokines that are pertinent to glucose and lipid homeostasis, as well as inflammation. Importantly, the obesity-induced adipose tissue expansion stimulates a plethora of signals capable of triggering an inflammatory response. These inflammatory manifestations of obese AT have been linked to insulin resistance, metabolic syndrome, and type 2 diabetes, and proposed to evoke obesity-induced comorbidities including cardiovascular diseases (CVDs). A growing body of evidence suggests that metabolic disorders, characterized by AT inflammation and accumulation around organs may eventually induce organ dysfunction through a direct local mechanism. Interestingly, perirenal adipose tissue (PRAT), surrounding the kidney, influences renal function and metabolism. In this regard, PRAT emerged as an independent risk factor for chronic kidney disease (CKD) and is even correlated with CVD. Here, we review the available evidence on the impact of PRAT alteration in different metabolic states on the renal and cardiovascular function. We present a broad overview of novel insights linking cardiovascular derangements and CKD with a focus on metabolic disorders affecting PRAT. We also argue that the confluence among these pathways may open several perspectives for future pharmacological therapies against CKD and CVD possibly by modulating PRAT immunometabolism.
راعي المشروعThis work was supported by AUB-Faculty of Medicine Medical Practice Plan Grant #320148 and an AUB President Collaborative Research Stimulus Grant to AE-Y.
اللغةen
الناشرFrontiers Media S.A.
الموضوعadipose tissue inflammation
cardiovascular disease
chronic kidney disease
metabolic dysfunction
perirenal adipose tissue
العنوانPerirenal Adipose Tissue Inflammation: Novel Insights Linking Metabolic Dysfunction to Renal Diseases
النوعArticle
رقم المجلد12
ESSN1664-2392
dc.accessType Open Access


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