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AuthorSouchelnytskyi, N.
AuthorKost, A.
AuthorSouchelnytskyi, S.
Available date2023-09-18T09:52:24Z
Publication Date2020
Publication NameProceedings of the Shevchenko Scientific Society. Medical Sciences
ResourceScopus
URIhttp://dx.doi.org/10.25040/ntsh2020.01.07
URIhttp://hdl.handle.net/10576/47639
AbstractDiagnostic based on analysis of living tumor cells is frequently used in oncology. Circulating tumor cells in the blood and cells obtained from a tumor biopsy are used to access their carcinogenic properties and subsequently to predict possible development of the disease. Here we report use of these two tests to assess aggressiveness and metastatic potential of a bronchial adenocarcinoma. The circulating tumor cells test was negative, no circulating cells was observed. It indicates that there was no metastatic spread. However, test with the surgery biopsy showed presence of aggressive cellular clones. The tumor cells from the biopsy proliferated and spread from the cultured tissue. Moreover, the tumor cells formed colonies of cells which lost contact inhibition. This is an indication of aggressive carcinogenic features of the cells in tumor organoids. Combination of both tests showed that the local tumor had an aggressive phenotype, but no detectable spreading of cells. Therefore, these tests support a management plan with removal the primary tumor and regular monitoring, without need of an extensive chemotherapy.
Languageen
PublisherDanylo Halytskyi Lviv National Medical University
SubjectCirculating Neoplastic Cells
Breast Neoplasms
Circulating Tumor DNA
TitleCell-based diagnostic of bronchial carcinoma: Case study of a diagnostic value of tests of circulating tumor cells and organoid culture
TypeArticle
Pagination93-98
Issue Number1
Volume Number59
dc.accessType Abstract Only


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