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المؤلفHroncekova, Stefania
المؤلفBertok, Tomas
المؤلفHires, Michal
المؤلفJane, Eduard
المؤلفLorencova, Lenka
المؤلفVikartovska, Alica
المؤلفTanvir, Aisha
المؤلفKasak, Peter
المؤلفTkac, Jan
تاريخ الإتاحة2023-09-18T11:20:59Z
تاريخ النشر2020-05-01
اسم المنشورProcesses
المعرّفhttp://dx.doi.org/10.3390/PR8050580
الاقتباسHroncekova, S., Bertok, T., Hires, M., Jane, E., Lorencova, L., Vikartovska, A., ... & Tkac, J. (2020). Ultrasensitive Ti3C2TX MXene/chitosan nanocomposite-based amperometric biosensor for detection of potential prostate cancer marker in urine samples. Processes, 8(5), 580.‏
معرّف المصادر الموحدhttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85085886123&origin=inward
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47655
الملخصTwo-dimensional layered nanomaterial Ti3C2TX (a member of the MXene family) was used to immobilise enzyme sarcosine oxidase to fabricate a nanostructured biosensor. The device was applied for detection of sarcosine, a potential prostate cancer biomarker, in urine for the first time. The morphology and structures of MXene have been characterised by atomic force microscopy (AFM) and scanning electron microscopy (SEM). Electrochemical measurements, SEM and AFM analysis revealed that MXene interfaced with chitosan is an excellent support for enzyme immobilisation to fabricate a sensitive biosensor exhibiting a low detection limit of 18 nM and a linear range up to 7.8 μM. The proposed biosensing method also provides a short response time of 2 s and high recovery index of 102.6% for detection of sarcosine spiked into urine sample in a clinically relevant range.
راعي المشروعThe financial support received from, from the Slovak Research and Development Agency APVV 17-0300 is acknowledged. We would like to acknowledge the support from the ERC Proof of Concept grant (No. 825586). This work was made possible by NPRP grant # 9-219-2-105 from the Qatar National Research Fund (A Member of The Qatar Foundation). The findings achieved herein are solely the responsibility of the authors. We would like to acknowledge the support received from the Ministry of Health of the Slovak Republic under the project registration number 2019/68-CHÚSAV-1.
اللغةen
الناشرMDPI AG
الموضوعBiosensor
MXene
Nanocomposite
Prostate cancer
Sarcosine
Sarcosine oxidase
العنوانUltrasensitive Ti3C2TX MXene/chitosan nanocomposite-based amperometric biosensor for detection of potential prostate cancer marker in urine samples
النوعArticle
رقم العدد5
رقم المجلد8
dc.accessType Open Access


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