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المؤلفEl-Baba, Chirine
المؤلفEid, Ali H.
المؤلفShaito, Abdallah
المؤلفKobeissy, Firas
المؤلفDarwiche, Nadine
تاريخ الإتاحة2023-09-25T10:26:15Z
تاريخ النشر2022
اسم المنشورHandbook of Oxidative Stress in Cancer: Mechanistic Aspects
المصدرScopus
معرّف المصادر الموحدhttp://dx.doi.org/10.1007/978-981-15-9411-3_186
معرّف المصادر الموحدhttp://hdl.handle.net/10576/47933
الملخصRetinoids are a large family of structurally related natural and synthetic molecules that exhibit a variety of effects in embryogenesis and adult life. The parent compound of retinoids is vitamin A which was first discovered for its impact on vision and later on cell proliferation, cell differentiation, and cell death. Clinically, retinoids were used for six decades in cancer management as they exhibit antitumor effects such as inhibiting cellular proliferation, inducing apoptosis, modulating cell cycle, and cell differentiation. Initially, early research focused on the mechanism of action of retinoids by their binding to retinoic acid receptors. However, recently accumulated evidence points that retinoids can act independent of the retinoid receptor signaling pathway for example by inducing stress, changes in redox balance, and reactive oxygen species (ROS) generation, and modulation of pathways that do not require binding of transcription factors to retinoic acid responsive DNA sequences. This review focuses on the mechanism of action of natural as well as synthetic retinoids, in particular, on the generation of ROS in in vitro and in vivo tumor models. A better understanding of the effects of retinoids on cellular redox balance and oxidative stress will impact future strategies of cancer management and therapy.
اللغةen
الناشرSpringer Nature
الموضوعCancer therapeutics
Cell death
Oxidative stress
Reactive oxygen species
Retinoids
العنوانRetinoids and Reactive Oxygen Species in Cancer Cell Death and Therapeutics
النوعBook chapter
الصفحات2589-2610
رقم المجلد3
dc.accessType Abstract Only


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