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Chapter Four Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach

Priya, N. Madhana; Balasundaram, Ambritha; Kumar , N. Sidharth; Udhaya Kumar, S.; Kumar, S. Udhaya; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Cyclin-dependent kinase 6 (CDK6) is an essential kinase in cell cycle progression, which is a viable target for inhibitors in various malignancies, including breast cancer. This study aimed to virtually screen efficient ...

Chapter Three Elucidating the mechanism of antimicrobial resistance in Mycobacterium tuberculosis using gene interaction networks

Keerthana, G.; Vasudevan, Karthick; Dey, Hrituraj; Kausar, Tasmia; Kumar, S. Udhaya; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Antimicrobial resistance (AMR) in microorganisms is an urgent global health threat. AMR of Mycobacterium tuberculosis is associated with significant morbidity and mortality. It is of great importance to underpin the ...

Molecular characterization of circadian gene expression and its correlation with survival percentage in colorectal cancer patients

Datta, Ankur; Cathryn R., Hephzibah; Kumar S., Udhaya; Vasudevan, Karthick; Kumar, Thirumal D.; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Colorectal cancer (CRC) is a form of cancer characterized by many symptoms and readily metastasizes to different organs in the body. Circadian rhythm is one of the many processes that is observed to be dysregulated in ...

Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis

S., Sri Hari; G., Keerthana; Dey, Hrituraj; Sangoji, Rahul V.; Thirumal Kumar, D.; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Colorectal cancer (CRC) is third cancer causing death in the world. CRC is associated with disrupting the circadian rhythm (CR), closely associating the CRC progression and the dysregulation of genes involved in the ...

Chapter Seven Exploring the effect of disease causing mutations in metal binding sites of human ARSA in metachromatic leukodystrophy

Madhana Priya, N.; Sidharth Kumar, N.; Udhaya Kumar, S.; Mohanraj, G.; Magesh, R.; ... more authors ... less authors ( Elsevier , 2024 , Book chapter)

The arylsulfatase A (ARSA) gene is observed to be deficient in patients with metachromatic leukodystrophy (MLD), a type of lysosomal storage disease. MLD is a severe neurodegenerative disorder characterized by an autosomal ...

Senolytics in diseases: killing to survive

Massoud, Gaelle P.; Eid, Ali E.; Booz, George W.; Rached, Layale; Yabluchanskiy, Andriy; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Since the discovery of cellular senescence in 1961, numerous studies have investigated the role of senescent cells in the pathogenesis of many chronic diseases. Cellular senescence, defined by irreversible cell cycle arrest, ...

Taxane formulations: From plant to clinic

Elhissi, A.; Mahmood, R.; Parveen, I.; Vali, A.; Ahmed, W.; ... more authors ... less authors ( Springer International Publishing , 2017 , Book chapter)

Taxanes including paclitaxel and docetaxel are highly active against many types of cancers. The main obstacle with developing delivery systems of taxanes is their poor water solubility. In this chapter, taxanes were reviewed ...

Hepatitis E Viruses : Emerging and Transboundary Animal Viruses

Kumar, Harsh; Kamar, Nassim; Nasrallah, Gheyath K.; Kumar, Dinesh ( Springer , 2020 , Book chapter)

Hepatitis E virus (HEV), member of genus Orthohepevirus in the family Hepeviridae, is the leading cause of hepatitis E. More than 20 million cases of hepatitis E virus (HEV) infection have been reported globally, out of ...

Computational and modeling approaches to understand the impact of the Fabry's disease causing mutation (D92Y) on the interaction with pharmacological chaperone 1-deoxygalactonojirimycin (DGJ).

Thirumal Kumar, D; Judith, E; Priyadharshini Christy, J; Siva, R; Tayubi, Iftikhar Aslam; ... more authors ... less authors ( Elsevier , 2019 , Book chapter)

Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in α-galactosidase A (GLA) protein were widely found to be causative for the Fabry's disease. These mutations ...

A comparative computational approach toward pharmacological chaperones (NN-DNJ and ambroxol) on N370S and L444P mutations causing Gaucher's disease.

Thirumal Kumar, D; Iyer, Sharada; Christy, J Priyadharshini; Siva, R; Tayubi, Iftikhar Aslam; ... more authors ... less authors ( Elsevier , 2019 , Book chapter)

Gaucher's disease (GD) is the most commonly known lysosomal disorder that occurs due to mutations in the β-glucocerebrosidase (GBA) protein. Our previous findings (Thirumal Kumar, Eldous, Mahgoub, George Priya Doss, Zayed, ...