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A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis

Udhaya Kumar, S.; Saleem, Aisha; Thirumal Kumar, D.; Anu Preethi, V.; Younes, Salma; ... more authors ... less authors ( Elsevier , 2021 , Book chapter)

Background and aim: The persistence of extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (MTB) continue to pose a significant challenge to the treatment and control of tuberculosis infections worldwide. ...

An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)-A systems biology approach

Udhaya Kumar, S.; Madhana Priya, N.; Thirumal Kumar, D.; Anu Preethi, V.; Kumar, Vibhaa; ... more authors ... less authors ( Elsevier , 2021 , Book chapter)

Lung Emphysema is an abnormal enlargement of the air sacs followed by the destruction of alveolar walls without any prominent fibrosis. This study primarily identifies the differentially expressed genes (DEGs), interactions ...

Analysis of signaling cascades from myeloma cells treated with pristimerin

Almaghrbi, Heba; Elkardawy, Rehab; Kumar. S, Udhaya; Kuttikrishnan, Shilpa; Abunada, Taghreed; ... more authors ... less authors ( Elsevier , 2022 , Book chapter)

Multiple myeloma (MM) is the 2nd most frequently diagnosed blood cancer after non-Hodgkin's lymphoma. The present study aimed to identify the differentially expressed genes (DEGs) between the control and pristimerin-treated ...

A review of bioinformatics tools and web servers in different microarray platforms used in cancer research

Hephzibah Cathryn, R.; Udhaya Kumar, S.; Younes, Salma; Zayed, Hatem; George Priya Doss, C. ( Elsevier , 2022 , Book chapter)

Over the past decade, conventional lab work strategies have gradually shifted from being limited to a laboratory setting towards a bioinformatics era to help manage and process the vast amounts of data generated by omics ...

Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface

Thirumal Kumar, D.; Udhaya Kumar, S.; Jain, Nikita; Sowmya, Baviri; Balsekar, Kamakshi; ... more authors ... less authors ( Elsevier , 2022 , Book chapter)

Breast cancer type 1 susceptibility protein (BRCA1) is closely related to the BRCA2 (breast cancer type 2 susceptibility protein) and BARD1 (BRCA1-associated RING domain-1) proteins. The homodimers were formed through their ...

Integrative ontology and pathway-based approach identifies distinct molecular signatures in transcriptomes of esophageal squamous cell carcinoma

Udhaya Kumar, S.; Balasundaram, Ambritha; Anu Preethi, V.; Chatterjee, Sayoni; Kameshwari Gollakota, G.V.; ... more authors ... less authors ( Elsevier , 2022 , Book chapter)

Esophageal squamous cell carcinoma (ESCC) remains a serious concern globally due to many factors that including late diagnosis, lack of an ideal biomarker for diagnosis and prognosis, and high rate of mortality. In this ...

Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis

Udhaya Kumar, S.; Datta, Ankur; Gnanasambandan, Ramanathan; Younes, Salma; Medha, Tamma; ... more authors ... less authors ( Elsevier , 2022 , Book chapter)

Multiple Sclerosis (MS) is a neurodegenerative autoimmune and organ-specific demyelinating disorder, known to affect the central nervous system (CNS). While genetic studies have revealed several critical genes and diagnostic ...

Chapter Three Elucidating the mechanism of antimicrobial resistance in Mycobacterium tuberculosis using gene interaction networks

Keerthana, G.; Vasudevan, Karthick; Dey, Hrituraj; Kausar, Tasmia; Udhaya Kumar, S.; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Antimicrobial resistance (AMR) in microorganisms is an urgent global health threat. AMR of Mycobacterium tuberculosis is associated with significant morbidity and mortality. It is of great importance to underpin the ...

Molecular characterization of circadian gene expression and its correlation with survival percentage in colorectal cancer patients

Ankur, Datta; R., Hephzibah Cathryn; Udhaya Kumar, S.; Vasudevan, Karthick; Thirumal Kumar, D.; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Colorectal cancer (CRC) is a form of cancer characterized by many symptoms and readily metastasizes to different organs in the body. Circadian rhythm is one of the many processes that is observed to be dysregulated in ...

Chapter Four Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach

N., Madhana Priya; Balasundaram, Ambritha; Sidharth Kumar, N.; Udhaya Kumar, S.; Thirumal Kumar, D.; ... more authors ... less authors ( Elsevier , 2023 , Book chapter)

Cyclin-dependent kinase 6 (CDK6) is an essential kinase in cell cycle progression, which is a viable target for inhibitors in various malignancies, including breast cancer. This study aimed to virtually screen efficient ...