Biomedical Sciences: Recent submissions
Now showing items 1-20 of 774
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Efficient and regioselective synthesis of ortho-diiodinated homobenzylic alcohol derivatives: in silico evaluation as potential anticancer IDO/TDO inhibitors
( Royal Society of Chemistry , 2024 , Article)A simple and direct synthesis of 2,6-diiodophenylethanol building blocks through highly regioselective metalation (MIE)/oxirane SN2-type ring opening of 1,2,3-triiodobenzene is described. A significant impact of the nature ... -
The journey of female surgeons in the arab region: A scoping review
( Elsevier , 2024 , Article)BackgroundIn the Arab region, there's a dearth of research on female surgeons' experiences and challenges. To address this gap, a scoping review aims to map existing literature. It seeks to understand the hurdles faced by ... -
The Yemeni genetic structure revealed by the Y chromosome STRs
( Springer , 2025 , Article)Yemen, with its rich historical background and strategic geographical position at a major crossroads of trade and migration, offers an ideal setting for exploring population genetics. This study aimed to develop a Y-STR ... -
The role of PTP1B in cardiometabolic disorders and endothelial dysfunction
( Taylor and Francis Ltd. , 2025 , Article Review)Cardiovascular diseases (CVD) are a global health concern that accounts for a large share of annual mortality. Endothelial dysfunction is the main underlying factor that eventually leads to cardiovascular events. Recent ... -
Exploring TGF-β Signaling in Cancer Progression: Prospects and Therapeutic Strategies
( Dove Medical Press Ltd , 2025 , Article Review)Cancer persists as a ubiquitous global challenge despite the remarkable advances. It is caused by uncontrolled cell growth and metastasis. The Transforming Growth Factor-beta (TGF-β) signaling pathway is considered a primary ... -
A customizable multiplex protein microarray for antibody testing and its application for tick-borne and other infectious diseases
( Springer Nature , 2025 , Article)Tick-borne infections are the most common vector-borne diseases in the USA. Ticks harbor and transmit several infections with Lyme disease being the most common tickborne infection in the US and Europe. Lack of awareness ... -
Finite Element Analysis of Evolut Transcatheter Heart Valves: Effects of Aortic Geometries and Valve Sizes on Post-TAVI Wall Stresses and Deformations
( MDPI , 2025 , Article)Background/Objectives: For transcatheter aortic valve implantation (TAVI) therapy, a catheter-guided crimped valve is deployed into the aortic root. Valve types such as Edwards balloon-expandable valves and Medtronic ... -
Regioselective domino C–C/C–O arylation of 1,2,3-triiodobenzenes and 1,3-diketones: Synthesis and in silico evaluation of 7-iodobenzo[b]furan as potential ALK inhibitors
( Elsevier , 2025 , Article)We report a simple, direct, and regioselective protocol for the synthesis of 2,3-disubstituted 7-iodobenzo[b]furans via domino double CC/CO arylations of 1,2,3-triiodobenzene and 1,3-dicarbonyl compounds. Remarkably, the ... -
Highly fluorescent push-pull bis-coumarinyl sulfone: Synthesis, photophysical behavior, and solvatochromic response
( Elsevier , 2025 , Article)In this work, 3,3′-sulfonylbis(7-(diethylamino)-2H-chromen-2-one), an effective fluorescent push-pull system, is synthesized and photophysically characterized. The donor-π–acceptor–π–donor (D–π–A–π–D) architecture of the ... -
Machine learning for predicting outcomes of transcatheter aortic valve implantation: A systematic review
( Elsevier , 2025 , Article)BackgroundTranscatheter aortic valve implantation (TAVI) therapy has demonstrated its clear benefits such as low invasiveness, to treat aortic stenosis. Despite associated benefits, still post-procedural complications might ... -
Rapid wall shear stress prediction for aortic aneurysms using deep learning: a fast alternative to CFD
( Springer Nature , 2025 , Article)Abstract: Aortic aneurysms pose a significant risk of rupture. Previous research has shown that areas exposed to low wall shear stress (WSS) are more prone to rupture. Therefore, precise WSS determination on the aneurysm ... -
Evaluating chemiluminescent immunoassays for syphilis detection: A comparative analysis
( Elsevier , 2025 , Article)BackgroundSyphilis, caused by Treponema pallidum (TP), remains a significant global public health concern, with approximately 8 million new cases annually. Diagnosing syphilis is challenging due to its often-asymptomatic ... -
Evaluating Hospital Admission Data as Indicators of COVID-19 Severity: A National Assessment in Qatar.
( Oxford University Press , 2025 , Article)Accurately assessing SARS-CoV-2 infection severity is essential for understanding the health impact of the infection and evaluating the effectiveness of interventions. This study investigated whether SARS-CoV-2-associated ... -
Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells
( Springer Nature , 2025 , Article)Background: Cancer cells can modulate the expression of many proteins that are essential for supporting their uncontrolled proliferation. Heat shock protein 90 (HSP90) is ubiquitously expressed in most cell types and ... -
The molecular mechanism of nitric oxide in memory consolidation and its role in the pathogenesis of memory-related disorders
( Springer Nature , 2025 , Article)Memory is a dynamic process of encoding, storing, and retrieving information. It includes sensory, short-term, and long-term memory, each with unique characteristics. Nitric oxide (NO) is a biological messenger synthesized ... -
Indications and clinical outcomes of percutaneous cholecystostomies in acute cholecystitis: a study from Qatar.
( BioMed Central , 2025 , Article)Acute cholecystitis (AC) is a prevalent condition in emergency departments (EDs). Standard care involves early laparoscopic cholecystectomy; however, in cases of delayed presentation, high surgical risk, or during situations ... -
Advancing Medical Research Through Artificial Intelligence: Progressive and Transformative Strategies: A Literature Review
( John Wiley & Sons , 2025 , Article)Background and Aims: Artificial intelligence (AI) has become integral to medical research, impacting various aspects such as data analysis, writing assistance, and publishing. This paper explores the multifaceted influence ... -
Seroprevalence of influenza A H1N1 and influenza D viruses in ruminants in Qatar
( Elsevier , 2025 , Article)BackgroundInfluenza is among the most common viruses affecting humans and many animals worldwide. While influenza A (IAV) and D (IDV) viruses are associated with respiratory disease in humans and animals, respectively, ... -
Association between clinical laboratory indicators and WOMAC scores in Qatar Biobank participants: The impact of testosterone and fibrinogen on pain, stiffness, and functional limitation
( Walter de Gruyter GmbH , 2025 , Article)Objectives: The association between baseline laboratory parameters and experienced well-being in healthy individuals remains uncertain. This study explored the relationship between clinical laboratory profiles and Western ... -
Unveiling GATA3 Signaling Pathways in Health and Disease: Mechanisms, Implications, and Therapeutic Potential
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)GATA binding protein 3 (GATA3), a member of the GATA family transcription factors, is a key player in various physiological and pathological conditions. It is known for its ability to bind to the DNA sequence "GATA", which ...
