Browsing Biomedical Sciences by Author "Doss, C. George Priya"
Now showing items 1-14 of 14
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Analysis of signaling cascades from myeloma cells treated with pristimerin
Almaghrbi, Heba; Elkardawy, Rehab; Kumar. S, Udhaya; Kuttikrishnan, Shilpa; Abunada, Taghreed; Kashyap, Manoj Kumar; Ahmad, Aamir; Uddin, Shahab; Doss. C, George Priya; Zayed, Hatem... more authors ... less authors ( Elsevier , 2022 , Book chapter)Multiple myeloma (MM) is the 2nd most frequently diagnosed blood cancer after non-Hodgkin's lymphoma. The present study aimed to identify the differentially expressed genes (DEGs) between the control and pristimerin-treated ... -
Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA
Tanwar, Himani; Kumar, D Thirumal; Doss, C George Priya; Zayed, Hatem ( Springer US , 2019 , Article)Mucopolysaccharidosis (MPS) IIIA, also known as Sanfilippo syndrome type A, is a severe, progressive disease that affects the central nervous system (CNS). MPS IIIA is inherited in an autosomal recessive manner and is ... -
Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
Doss, C. George Priya; Alasmar, Dima R.; Bux, Reem I.; Sneha, P.; Bakhsh, Fadheela Dad; Al-Azwani, Iman; El Bekay, Rajaa; Zayed, Hatem... more authors ... less authors ( Nature Publishing Group , 2016 , Article)A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) ... -
Implication of salt stress induces changes in pigment production, antioxidant enzyme activity, and qRT-PCR expression of genes involved in the biosynthetic pathway of Bixa orellana L.
Sankari, M; Hridya, H; Sneha, P; Doss, C George Priya; Christopher, J Godwin; Mathew, Jill; Zayed, Hatem; Ramamoorthy, Siva... more authors ... less authors ( Springer Verlag , 2019 , Article)The effect of salt stress on pigment synthesis and antioxidant enzyme activity as well as in the genes involved in the biosynthetic pathway of bixin was studied. The 14-day germinated seedlings of Bixa orellana were induced ... -
Integrated gene network analysis sheds light on understanding the progression of Osteosarcoma
Dey, Hrituraj; Vasudevan, Karthick; Doss C, George Priya; Kumar, S. Udhaya; El Allali, Achraf; Alsamman, Alsamman M.; Zayed, Hatem... more authors ... less authors ( National library of medicine , 2023 , Article)Introduction: Osteosarcoma is a rare disorder among cancer, but the most frequently occurring among sarcomas in children and adolescents. It has been reported to possess the relapsing capability as well as accompanying ... -
Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer.
Kumar, S Udhaya; Kumar, D Thirumal; R, Siva; Doss, C George Priya; Zayed, Hatem ( Frontiers Media , 2019 , Article)Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might be involved in the molecular pathogenesis of OC. In the present ... -
Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III.
Kumar, S Udhaya; Sankar, Srivarshini; Kumar, D Thirumal; Younes, Salma; Younes, Nadin; Siva, R; Doss, C George Priya; Zayed, Hatem... more authors ... less authors ( Springer , 2021 , Article)Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the ... -
Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach
S, Udhaya Kumar; R, Bithia; D, Thirumal Kumar; Doss, C George Priya; Zayed, Hatem ( Taylor and Francis , 2020 , Article)K-Ras is a small GTPase and acts as a molecular switch by recruiting GEFs and GAPs, and alternates between the inert GDP-bound and the dynamic GTP-bound forms. The amino acid at position 12 of K-Ras is a hot spot for ... -
Potential routes of spread of Zika virus to the Middle East, North Africa and Asia: Action must be taken
Zayed, Hatem; Doss C, George Priya; El Zowalaty, Mohamed Ezzat ( Future Medicine Ltd. , 2017 , Article Review)[No abstract available] -
Retinopathy of Type 1 Diabetes in Arab Countries: Systematic Review and Meta-Analysis.
Zayed, Hatem; Abdel Motal, Ussama M; Gopalakrishnan, Akila; Ponnuraja, Chinnayan; Doss, C George Priya; Rizk, Nasser; Shebl, Fatma M... more authors ... less authors ( Karger , 2018 , Article Review)To conduct a systematic review and meta-analysis of retinopathy prevalence in patients with type 1 diabetes (T1D) in 22 Arab countries. We systematically searched 4 different literature databases (PubMed, Science Direct, ... -
A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing
Kumar, S. Udhaya; Priya, N. Madhana; Nithya, S. R.; Kannan, Priyanka; Jain, Nikita; Kumar, D. Thirumal; Magesh, R.; Younes, Salma; Zayed, Hatem; Doss, C. George Priya... more authors ... less authors ( Springer Verlag , 2021 , Article Review)Coronavirus disease (COVID-19) pandemic is instigated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of March 13, 2021, more than 118.9 million cases were infected with COVID-19 worldwide. SARS-CoV-2 ... -
Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2.
Kumar D, Thirumal; Shaikh, Nishaat; Kumar S, Udhaya; Doss C, George Priya; Zayed, Hatem ( Frontiers Media , 2021 , Article)The number of confirmed COVID-19 cases is rapidly increasing with no direct treatment for the disease. Few repurposed drugs, such as Remdesivir, Chloroquine, Hydroxychloroquine, Lopinavir, and Ritonavir, are being tested ... -
Unraveling the Dysbiosis of Vaginal Microbiome to Understand Cervical Cancer Disease Etiology—An Explainable AI Approach
Sekaran, Karthik; Varghese, Rinku Polachirakkal; Gopikrishnan, Mohanraj; Alsamman, Alsamman M.; El Allali, Achraf; Zayed, Hatem; Doss C, George Priya... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Microbial Dysbiosis is associated with the etiology and pathogenesis of diseases. The studies on the vaginal microbiome in cervical cancer are essential to discern the cause and effect of the condition. The present study ... -
Whole-exome sequencing analysis of NSCLC reveals the pathogenic missense variants from cancer-associated genes
Kumar S, Udhaya; Balasundaram, Ambritha; Cathryn R, Hephzibah; Varghese, Rinku Polachirakkal; R, Siva; R, Gnanasambandan; Younes, Salma; Zayed, Hatem; Doss C, George Priya... more authors ... less authors ( Elsevier , 2022 , Article)Background: Non-small-cell lung cancer (NSCLC) is the most common type of lung cancer. NSCLC accounts for 84% of all lung cancer cases. In recent years, advances in pathway understanding, methods for discovering novel ...