Browsing Biomedical Sciences by Author "Nasrallah, Gheyath"
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Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
Al-Sharshani, Dalal; Velayutham, Dinesh; Samara, Muthanna; Gazal, Reham; Al Haj Zen, Ayman; Ismail, Mohamed A.; Ahmed, Mahmoud; Nasrallah, Gheyath; Younes, Salma; Rizk, Nasser; Hammuda, Sara; Qoronfleh, M. Walid; Farrell, Thomas; Zayed, Hatem; Abdulrouf, Palli Valapila; AlDweik, Manar; Silang, John Paul Ben; Rahhal, Alaa; Al-Jurf, Rana; Mahfouz, Ahmed; Salam, Amar; Al Rifai, Hilal; Al-Dewik, Nader I.... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Background: Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Objective: The study aimed to investigate ... -
Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile.
Nasrallah, Gheyath; Salem, Rola; Da'as, Sahar; Al-Jamal, Ola Loay Ahmad; Scott, Mark; Mustafa, Ibrahim... more authors ... less authors ( Elsevier , 2019 , Article)Clinically approved iron chelators are effective in decreasing significant transfusional iron accumulation. Starch-Deferoxamine (S-DFO), a novel high molecular weight iron chelator, was produced to increase binding capacity ... -
Comparative Serological Study for the Prevalence of Anti-MERS Coronavirus Antibodies in High- and Low-Risk Groups in Qatar
Al Kahlout, Reham; Nasrallah, Gheyath; Farag, Elmoubasher; Wang, Lingshu; Lattwein, Erik; Müller, Marcel; El Zowalaty, Mohamed; Al Romaihi, Hamad; Graham, Barney; Al Thani, Asmaa; Yassine, Hadi... more authors ... less authors ( Hindawi Publishing Corporation , 2019 , Article)Infection with Middle East respiratory syndrome coronavirus (MERS-CoV) could be asymptomatic or cause mild influenza-like illness. Therefore, the prevalence of MERS-CoV infections in the general population could be ... -
Co‑prevalence of human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) in healthy blood donors from diverse nationalities in Qatar
Gupta, Ishita; Nasrallah, Gheyath; Sharma, Anju; Jabeen, Ayesha; Smatti, Maria; Al‑Thawadi, Hamda; Sultan, Ali; Alkhalaf, Moussa; Vranic, Semir; Al Moustafa, Ala‑Eddin... more authors ... less authors ( BMC , 2020 , Article)Background: Infections by both human oncoviruses, human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) are very common in the adult human population and are associated with various malignancies. While HPV is ... -
Curcumin a Colorimetric and Fluorimetric Cyanide Probe in Aqueous System and Living Cells
Hijji, Yousef; Elsafi, Anas; Al Easa, Hala; Attili, Bassam; Abdelrasoul, Mahmoud; Mohamed, Nura; Nasrallah, Gheyath... more authors ... less authors ( Royal Society of Chemistry , 2019 , Article)Curcumin, 1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hepta-diene-3,5-dione, is a natural product obtained from the rhizome of Curcuma longa. Curcumin has been demonstrated to be a strong antioxidant with anticancer properties ... -
D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis
Paliogiannis, Panagiotis; Mangoni, Arduino; Dettori, Paola; Nasrallah, Gheyath; Pintus, Gianfranco; Zinellu, Angelo... more authors ... less authors ( Frontiers Media , 2020 , Article Review)Coronavirus disease 2019 (COVID-19) is a recently described infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since late 2019, COVID-19 has rapidly spread in virtually all countries, ... -
Ecotoxicological assessment of Ti3C2Tx (MXene) using a zebrafish embryo model
Nasrallah, Gheyath; Al-Asmakh, Maha; Rasool, Kashif; Mahmoud, Khaled ( Royal Society of Chemistry , 2018 , Article)The recent application of 2D Ti3C2Tx (MXene) nanomaterials as adsorbents and membranes for water treatment as well as for biomedical applications is attracting a growing interest. However, the environmental impact of MXene ... -
Ecotoxicological assessment of two surfactant on the emryonic development
Al-dosari, Aldana; Younes, Nadin; Nasrallah, Gheyath ( Qatar University Press , 2021 , Poster)In this study, zebrafish (Danio rerio) embryos was served as a model for marine fauna to determine if there is any potential of organ-specific toxicity (neuromuscular, hepatic, cytotoxic, and cardiac) caused by Silicone-Q-22 ... -
EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: potential link with oxidative stress
Giordo, Roberta; Mohammed, Yusra; Allam, Hilda; Abusnana, Salah; Pappalardo, Lucia; Nasrallah, Gheyath; Mangoni, Arduino; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media , 2021 , Article)Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. ... -
Human c-MYBPC3 RNA Targeted Therapy, Reversal of Hypertrophic Cardiomyopathy in the Zebrafish Model
Yalcin, Huseyin; Da'As, Sahar; Mohammed, Iman; Nasrallah, Gheyath; Al Suwaidi, Jasim; Yacoub, Magdi... more authors ... less authors ( Qscience. , 2016 , Conference Paper)Hypertrophic cardiomyopathy (HCM) is a serious heart disease and is defined as abnormal left ventricular (LV) wall thickening with diastolic dysfunction. HCM is an autosomal dominant monogenic disease caused by a mutation ... -
Immunomodulatory and Anti-Inflammatory Effects of Berberine in Lung Tissue and its Potential Application in Prophylaxis and Treatment of COVID-19
Majdalawieh, Amin; Yousef, Sarah; Abu-Yousef, Imad; Nasrallah, Gheyath ( IMR Press , 2022 , Article Review)Natural products with known safety profiles are a promising source for the discovery of new drug leads. Berberine presents an example of one such phytochemical that has been extensively studied for its anti-inflammatory ... -
Incidence, risk factors, and feto-maternal outcomes of inappropriate birth weight for gestational age among singleton live births in Qatar: A population-based study
Younes, Salma; Samara, Muthanna; Salama, Noor; Al-Jurf, Rana; Nasrallah, Gheyath; Al-Obaidly, Sawsan; Salama, Husam; Olukade, Tawa; Hammuda, Sara; Abdoh, Ghassan; Abdulrouf, Palli Valapila; Farrell, Thomas; AlQubaisi, Mai; Al Rifai, Hilal; Al-Dewik, Nader... more authors ... less authors ( Public Library of Science , 2021 , Article)Background Abnormal fetal growth can be associated with factors during pregnancy and at postpartum. Objective In this study, we aimed to assess the incidence, risk factors, and feto-maternal outcomes associated with ... -
Incidence, Risk Factors, and Outcomes of Preterm and Early Term Births: A Population-Based Register Study
Younes, Salma; Samara, Muthanna; Al-Jurf, Rana; Nasrallah, Gheyath; Al-Obaidly, Sawsan; Salama, Husam; Olukade, Tawa; Hammuda, Sara; Ismail, Mohamed; Abdoh, Ghassan; Abdulrouf, Palli Valapila; Farrell, Thomas; AlQubaisi, Mai; Al Rifai, Hilal; Al-Dewik, Nader... more authors ... less authors ( MDPI , 2021 , Article)Preterm birth (PTB) and early term birth (ETB) are associated with high risks of perinatal mortality and morbidity. While extreme to very PTBs have been extensively studied, studies on infants born at later stages of ... -
Increased Receptor Affinity and Reduced Recognition by Specific Antibodies Contribute to Immune Escape of SARS-CoV-2 Variant Omicron
Vogt, Anne-Cathrine; Augusto, Gilles; Martina, Byron; Chang, Xinyue; Nasrallah, Gheyath; Speiser, Daniel; Vogel, Monique; Bachmann, Martin; Mohsen, Mona... more authors ... less authors ( MDPI , 2022 , Article)In this report, we mechanistically reveal how the Variant of Concern (VOC) SARS-CoV-2 Omicron (B.1.1.529) escapes neutralizing antibody responses, by physio-chemical characterization of this variant in comparison to the ... -
Is it the time for Hepatitis E virus (HEV) Testing for Blood Donors in Qatar?
Nasrallah, Gheyath; Hedaya, Laila; Ali, Fatima; Alhusaini, Abdellatif; Al Absi, Enas; Sami, Mariam; Taleb, Sara... more authors ... less authors ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Background: HEV is the etiologic agent of acute hepatitis E. Although HEV usually causes a self-limiting infection, the disease may develop into a chronic or fulminant form of Hepatitis. Sporadic HEV infections spread in ... -
Molecular Subtyping of Blastocystis from Diverse Animals in the United Arab Emirates.
AbuOdeh, Raed; Ezzedine, Sinda; Madkour, Mohamed; Stensvold, Christen Rune; Samie, Amidou; Nasrallah, Gheyath; AlAbsi, Enas; ElBakri, Ali... more authors ... less authors ( Elsevier , 2019 , Article)The contribution of Blastocystis from non-human hosts to zoonotic transmission is only partly known. The objective of this study was to determine the distribution of Blastocystis genetic subtypes in different animal species ... -
Natural History, with Clinical, Biochemical and Molecular Characterization, of Classical Homocystinuria in the Qatari Population
Al-Dewik, Nader; Ali, Alaa; Mahmoud, Yassmin; Shahbeck, Noora; Ali, Rehab; Mahmoud, Laila; Al-Mureikhi, Mariam; Al-Mesaifri, Fatma; Musa, Sara; El-Akouri, Karen; AlMulla, Mariam; Al Saadi, Reem; Nasrallah, Gheyath; Samara, Muthanna; Abdoh, Ghassan; Al Rifai, Hilal; Häberle, Johannes; Thöny, Beat; Kruger, Warren; Blom, Henk J; Ben-Omran, Tawfeg... more authors ... less authors ( Wiley , 2019 , Article)Classical homocystinuria (HCU) is the most common inborn error of metabolism in Qatar, with an incidence of 1:1800, and is caused by the Qatari founder p.R336C mutation in the CBS gene. This study describes the natural ... -
Negative epidemiological association between HSV-1 and HSV-2 infections
Nasrallah, Gheyath; Dargham, Soha; Laith, Abu-Raddad ( Elsevier , 2019 , Article)Objectives: Existing evidence on an epidemiological association between herpes simplex virus (HSV) type 1 and type 2 infections remains conflicting and inconclusive. Using a multi-national database of HSV-1/2 serologica ... -
Neutralization of MERS coronavirus through a scalable nanoparticle vaccine
Mohsen, Mona O; Rothen, Dominik; Balke, Ina; Martina, Byron; Zeltina, Vilija; Inchakalody, Varghese; Gharailoo, Zahra; Nasrallah, Gheyath; Dermime, Said; Tars, Kaspars; Vogel, Monique; Zeltins, Andris; Bachmann, Martin F... more authors ... less authors ( Springer Nature , 2021 , Article)MERS-CoV continues to cause human outbreaks, so far in 27 countries worldwide following the first registered epidemic in Saudi Arabia in 2012. In this study, we produced a nanovaccine based on virus-like particles (VLPs). ... -
P3. 210 Estimating the antibody prevalence of herpes simplex virus type 2 among select middle east and north africa populations
Dargham, Soha; Nasrallah, Gheyath; Al-Absi, Enas; Mohammed, Layla; Al Disi, Rana; Noufal, Mariam; Abu-Raddad, Laith... more authors ... less authors ( BMJ Publishing Group , 2017 , Conference Proceedings)Introduction There are very limited data on herpes simplex virus type 2 (HSV-2) infection in the Middle East and North Africa (MENA). We examined the overall and age-specific HSV-2 antibody prevalence among select MENA ...