تصفح Biomedical Sciences حسب العنوان

السجلات المعروضة 642 -- 661 من 690

    • Therapeutic angiogenesis: From conventional approaches to recent nanotechnology-based interventions 

      Augustine R.; Prasad P.; Khalaf I.M.N. ( Elsevier Ltd , 2019 , Article Review)
      Intentional and regulated induction of blood vessels formation which is generally referred to as therapeutic angiogenesis has a lot of potential in the management of various kinds of ischemic complications as well as in ...

    • Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms 

      Hasan, Slika; Mansour, Hadi; Wehbe, Nadine; Nasser, Suzanne A.; Iratni, Rabah; ... more authors ( Elsevier , 2022 , Article)
      Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ...

    • The therapeutic potential of matcha tea: A critical review on human and animal studies 

      Sokary, Sara; Al-Asmakh, Maha; Zakaria, Zain; Bawadi, Hiba ( Elsevier , 2023 , Article Review)
      Matcha is a powdered form of Japanese green tea that has been gaining global popularity recently. Matcha tea has various health benefits, including an enhancing effect on cognitive function, cardio-metabolic health, and ...

    • Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes 

      Razali, Rozaimi Mohamad; Rodriguez-Flores, Juan; Ghorbani, Mohammadmersad; Naeem, Haroon; Aamer, Waleed; ... more authors ( Nature Research , 2021 , Article)
      Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ...

    • Thrombotic and Hypercoagulability Complications of COVID-19: An Update 

      Shibeeb, sapha; Ahmad, Muneera Naseer ( Dovepress , 2021 , Article)
      The current COVID-19 pandemic emerged in December 2019, in China, affecting millions of people worldwide. COVID-19 is mainly a disease of the respiratory system, yet systematic complications have also been reported among ...

    • Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators. 

      Almajali, Belal; Al-Jamal, Hamid Ali Nagi; Wan Taib, Wan Rohani; Ismail, Imilia; Johan, Muhammad Farid; ... more authors ( West Asia Organization for Cancer Prevention (WAOCP) , 2021 , Article)
      The natural compound, thymoquinone (TQ) has demonstrated potential anticancer properties in inhibiting cell proliferation and promoting apoptosis in myeloid leukemia cells, breast cancer cells, and others. However, the ...

    • Thymoquinone, as a Novel Therapeutic Candidate of Cancers 

      Almajali, Belal; Nagi, Hamid Ali; Taib, Wan Rohani Wan; Ismail, Imilia Ismail; Johan, Muhammad Farid; ... more authors ( MDPI , 2021 , Article)
      To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As ...

    • TLR4 Receptor D299G/T399I Haplotype Polymorphism Is Associated with Insulin Resistance in Obese Female Subjects 

      Sharif, Elham; Al-Wakeel, Mariam; Mohamed, Afnan; kerkadi, Abdelhamid; Rizk, Nasser M (2020 , Article)
      Background: Activation of Toll-like-receptor 4 (TLR4) causes chronic inflammation that can result in obesity and metabolic syndrome (MeS). Aim: This study aimed to investigate the role of TLR4 polymorphisms of TLR4D299G/T399I, ...

    • Total and high molecular weight adiponectin in patients with coronary artery disease 

      El-Menyar, Ayman; Rizk, Nasser; Al Nabti, Abdulrahman D.; Hassira, Sana Abu; Singh, Rajvir; ... more authors ( Wolters Kluwer Health , 2009 , Article)
      BACKGROUND: Serum adiponectin inversely correlates with the extent of coronary artery disease (CAD). OBJECTIVES: To investigate the clinical significance of measuring high molecular weight (HMW) adiponectin in addition to ...

    • Toxicity evaluation of selected ionic liquid compounds on embryonic development of Zebrafish. 

      Younes, Nadin; Salem, Rola; Al-Asmakh, Maha; Altamash, Tausif; Pintus, Gianfranco; ... more authors ( Elsevier , 2018 , Article)
      Hydrate formation in seafloor pipelines is considered an economic and flow assurance issue for the oil and gas industries. Ionic liquids (ILs) have been recently used as potential hydrate inhibitors. Although branded as ...

    • Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model 

      Da’as, Sahar Isa; Hasan, Waseem; Salem, Rola; Younes, Nadine; Abdelrahman, Doua; ... more authors ( MDPI , 2022 , Article)
      Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ...

    • The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1 

      Alsamman, Alsamman M; Zayed, Hatem ( Public Library of Science , 2020 , Article)
      The SARS-CoV-2 (COVID-19) pandemic is a global crisis that threatens our way of life. As of November 18, 2020, SARS-CoV-2 has claimed more than 1,342,709 lives, with a global mortality rate of ~2.4% and a recovery rate of ...

    • Traumatic brain injury: Oxidative stress and novel anti-oxidants such as mitoquinone and edaravone 

      Ismail, Helene; Shakkour, Zaynab; Tabet, Maha; Abdelhady, Samar; Kobaisi, Abir; ... more authors ( MDPI , 2020 , Article Review)
      Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually ...

    • Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties 

      Abbas, Tariq O.; Parangusan, Hemalatha; Yalcin, Huseyin C.; Hassan, Mohamed; Zakrif, Lubna; ... more authors ( IOP Publishing , 2024 , Article)
      Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ...

    • Tumor reversion: a dream or a reality. 

      Tripathi, Avantika; Kashyap, Anjali; Tripathi, Greesham; Yadav, Joni; Bibban, Rakhi; ... more authors ( Pubmed , 2021 , Article)
      Reversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative RNA splicing, ...

    • Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar 

      Chemaitelly, Hiam; Ayoub, Houssein H; Faust, Jeremy Samuel; Coyle, Peter; Tang, Patrick; ... more authors ( BMJ Publishing Group , 2023 , Article)
      Objective To assess the evolution of COVID-19 severity and fatality in a unique setting that consistently applied, throughout the pandemic, rigorous and standardised criteria for defining severe COVID-19 outcomes. Methods ...

    • Two patients with Canavan disease and structural modeling of a novel mutation. 

      Zaki, Osama K; Krishnamoorthy, Navaneethakrishnan; El Abd, Heba S; Harche, Soumaya A; Mattar, Reem A; ... more authors ( Springer US , 2017 , Article)
      Canavan disease (CD) is a rare fatal childhood neurological autosomal recessive genetic disease caused by mutations in the ASPA gene, which lead to catalytic deficiency of the ASPA enzyme, which catalyzes the hydrolysis ...

    • Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months 

      Laith J., Abu-Raddad; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; ... more authors ( Elsevier , 2021 , Article)
      We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ...

    • Uncommon presentation of complicated internal hernia through the appendices epiploicae ring of adhesion: a clinical case study 

      Ghali, Mohamed Said; Shehata, Mona S.; Al Obahi, Mohammed; Al-Zoubi, Raed M.; Zarour,Ahmad ( Frontiers Media , 2024 , Article)
      Background: Internal hernias are infrequent, yet serious, medical conditions with potentially severe consequences. An internal hernia resulting from an Appendices epiploicae (AE) ring is an especially rare cause, with a ...

    • UNCONVENTIONAL ANIMAL MODELS IN INFECTIOUS DISEASE RESEARCH 

      Nasrallah, Gheyath Khaled; Kamareddine, Layla; Baddal, Buket ( Frontiers , 2021 , E-Book)
      Apart from genetics and physiology, our understanding of other important aspects of the biological life, such as host-pathogen interactions stayed at its infancy for many years. Back then, many infectious diseases lacked ...