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    تصفح Biomedical Sciences حسب العنوان

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    السجلات المعروضة 76 -- 95 من 833

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      • Thumbnail

        Between Inflammation and Autophagy: The Role of Leptin-Adiponectin Axis in Cardiac Remodeling 

        Kamareddine, Layla; Ghantous, Crystal; Allouch, Soumaya; Al-Ashmar, Sara; Anlar, Gulsen; Kannan, Surya; Djouhri, Laiche; Korashy, Hesham; Agouni, Abdelali; Zeidan, Asad... more authors ... less authors ( Dove Medical Press , 2021 , Article Review)
        Cardiac remodeling is the process by which the heart adapts to stressful stimuli, such as hypertension and ischemia/reperfusion; it ultimately leads to heart failure upon long- term exposure. Autophagy, a cellular catabolic ...
      • Bidirectional communication between the Aryl hydrocarbon Receptor (AhR) and the microbiome tunes host metabolism 

        Korecka, Agata; Dona, Anthony; Lahiri, Shawon; Tett, Adrian James; Al-Asmakh, Maha; Braniste, Viorica; D'Arienzo, Rossana; Abbaspour, Afrouz; Reichardt, Nicole; Fujii-Kuriyama, Yoshiaki; Rafter, Joseph; Narbad, Arjan; Holmes, Elaine; Nicholson, Jeremy; Arulampalam, Velmurugesan; Pettersson, Sven... more authors ... less authors ( Nature Publishing Group in partnership with Nanyang Technological University , 2016 , Article)
        The ligand-induced transcription factor, aryl hydrocarbon receptor (AhR) is known for its capacity to tune adaptive immunity and xenobiotic metabolism-biological properties subject to regulation by the indigenous microbiome. ...
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        Biochemical and cellular basis of oxidative stress: Implications for disease onset 

        Aramouni, Karl; Assaf, Roland; Shaito, Abdullah; Fardoun, Manal; Al-Asmakh, Maha; Sahebkar, Amirhossein; Eid, Ali H.... more authors ... less authors ( Wiley , 2023 , Article Review)
        Cellular oxidation–reduction (redox) systems, which encompass pro- and antioxidant molecules, are integral components of a plethora of essential cellular processes. Any dysregulation of these systems can cause molecular ...
      • Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria 

        Al-Sadeq, Duaa W.; Conter, Carolina; Thanassoulas, Angelos; Al-Dewik, Nader; Safieh-Garabedian, Bared; Martínez-Cruz, Luis Alfonso; Nasrallah, Gheyath K.; Astegno, Alessandra; Nomikos, Michail... more authors ... less authors ( Portland Press Ltd , 2024 , Article)
        Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 50-phosphate (PLP)-dependent enzyme in the transsulfuration ...
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        Biocompatibility and toxicity of novel iron chelator Starch-Deferoxamine (S-DFO) compared to zinc oxide nanoparticles to zebrafish embryo: An oxidative stress based apoptosis, physicochemical and neurological study profile. 

        Nasrallah, Gheyath; Salem, Rola; Da'as, Sahar; Al-Jamal, Ola Loay Ahmad; Scott, Mark; Mustafa, Ibrahim... more authors ... less authors ( Elsevier , 2019 , Article)
        Clinically approved iron chelators are effective in decreasing significant transfusional iron accumulation. Starch-Deferoxamine (S-DFO), a novel high molecular weight iron chelator, was produced to increase binding capacity ...
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        Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA 

        Tanwar, Himani; Kumar, D Thirumal; Doss, C George Priya; Zayed, Hatem ( Springer US , 2019 , Article)
        Mucopolysaccharidosis (MPS) IIIA, also known as Sanfilippo syndrome type A, is a severe, progressive disease that affects the central nervous system (CNS). MPS IIIA is inherited in an autosomal recessive manner and is ...
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        Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach 

        Sekaran, Karthik; Alsamman, Alsamman M.; George Priya Doss, C.; Zayed, Hatem ( Springer , 2023 , Article)
        The progressive, chronic nature of Alzheimer's disease (AD), a form of dementia, defaces the adulthood of elderly individuals. The pathogenesis of the condition is primarily unascertained, turning the treatment efficacy ...
      • Biological and biomedical functions of Penta-O-galloyl-D-glucose and its derivatives 

        Cao, Yanyan; Himmeldirk, Klaus B.; Qian, Yanrong; Ren, Yulin; Malki, Ahmed; Chen, Xiaozhuo... more authors ... less authors ( Springer Nature , 2014 , Article Review)
        Penta-O-galloyl-D-glucose (PGG) is a simple hydrolysable tannin in plants. PGG exists in two anomeric forms, α-PGG and β-PGG. While β-PGG can be found in a wide variety of plants, α-PGG is rather rare in nature. Numerous ...
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        Biological applications of imiquimod analogues: An update (Review) 

        Obeid, Joelle; Shaito, Abdullah; Hajj, Hiba El; Deleuze-Masquefa, Carine; Bonnet, Pierre Antoine; El-Sabban, Marwan; Saliba, Jessica... more authors ... less authors ( Spandidos Publications , 2023 , Article Review)
        The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of ...
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        Biological Performance of Primary Dental Pulp Stem Cells Treated with Gold Nanoparticles 

        Abuarqoub, Duaa; Mahmoud, Nouf; Alshaer, Walhan; Mohammad, Marwa; Ibrahim, Abed Alqader; Al-Mrahleh, Mairvat; Alnatour, Mohammad; Alqudah, Dana A.; Esawi, Ezaldeen; Awidi, Abdalla... more authors ... less authors ( MDPI , 2023 , Article)
        Gold nanoparticles (AuNPs) are one of the most stable nanoparticles that have been prevalently used as examples for biological and biomedical applications. Herein, we evaluate the effect of AuNPs on the biological processes ...
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        Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences 

        Hoteit, R.; Hoteit, Reem; Yassine, Hadi M. ( MDPI , 2022 , Article Review)
        Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million ...
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        Biomaterials in Traumatic Brain Injury: Perspectives and Challenges 

        Aqel, Sarah; Al-Thani, Najlaa; Haider, Mohammad Z.; Abdelhady, Samar; Al Thani, Asmaa A.; Kobeissy, Firas; Shaito, Abdullah A.... more authors ... less authors ( MDPI , 2023 , Article Review)
        Traumatic brain injury (TBI) is a leading cause of mortality and long-term impairment globally. TBI has a dynamic pathology, encompassing a variety of metabolic and molecular events that occur in two phases: primary and ...
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        Bivalent mRNA-1273.214 vaccine effectiveness against SARS-CoV-2 omicron XBB* infections 

        Chemaitelly, Hiam; Ayoub, Houssein H.; AlMukdad, Sawsan; Faust, Jeremy S.; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Khatib, Hebah A.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H.; Latif, Ali N.; Shaik, Riyazuddin M.; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed G.; Butt, Adeel A.; Al-Romaihi, Hamad E.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors (2023 , Article)
        In October of 2022, Qatar introduced COVID-19 bivalent vaccination for persons ≥ 12 years using the 50-μg mRNA-1273.214 vaccine combining SARS-CoV-2 ancestral and omicron BA.1 strains.1 We estimated this vaccine’s effectiveness ...
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        Bladder neoplasms and NF-κB: an unfathomed association. 

        Jebaraj Walter, Charles Emmanuel; Durairajan, Sankari; Periyandavan, Kalaiselvi; Priya Doss C, George; Davis G, Dicky John; Vasanthi A, Hannah Rachel; Johnson, Thanka; Zayed, Hatem... more authors ... less authors ( Taylor & Francis , 2020 , Article)
        Bladder cancer is the second most common genitourinary tract cancer and is often recurrent and/or chemoresistant after tumor resection. Cigarette smoking, exposure to aromatic amines, and chronic infection/inflammation are ...
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        Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality 

        Shibeeb, Sapha; Abdallah, Atiyeh; Shi, Zumin ( Springer Nature , 2024 , Article)
        Lead is a heavy, toxic metal and its exposure to humans can lead to increased risk of cardiovascular disease development and mortality. Lead exposure has been shown to induce hyperhomocysteinemia (HHCy) which may be a major ...
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        BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar. 

        Tang, Patrick; Hasan, Mohammad R; Chemaitelly, Hiam; Yassine, Hadi M; Benslimane, Fatiha M; Al Khatib, Hebah A; AlMukdad, Sawsan; Coyle, Peter; Ayoub, Houssein H; Al Kanaani, Zaina; Al Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F; Nasrallah, Gheyath K; Al Kuwari, Mohamed Ghaith; Al Romaihi, Hamad Eid; Butt, Adeel A; Al-Thani, Mohamed H; Al Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J... more authors ... less authors ( Nature Researc , 2021 , Article)
        With the global expansion of the highly transmissible SARS-CoV-2 Delta (B.1.617.2) variant, we conducted a matched test-negative case-control study to assess the real-world effectiveness of COVID-19 messenger RNA vaccines ...
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        BNT162b2 antigen dose and SARS-CoV-2 omicron infection in adolescents 

        Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Khatib, Hebah A.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Al-Romaihi, Hamad Eid; Butt, Adeel A.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Elsevier , 2023 , Other)
        COVID-19 vaccine antigen dose might affect protection against SARS-CoV-2 infection,1, 2 but direct evidence to quantify this effect is absent. We conducted a matched, retrospective, cohort study using a regression ...
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        BNT162b2 Versus mRNA-1273 Vaccines: Comparative Analysis of Long-Term Protection Against SARS-CoV-2 Infection and Severe COVID-19 in Qatar 

        Chemaitelly, Hiam; Ayoub, Houssein H; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R; Yassine, Hadi M; Al Thani, Asmaa A; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F; Nasrallah, Gheyath K; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J... more authors ... less authors ( Wiley , 2024 , Article)
        Background: This study provides a head-to-head comparison of the protection provided by the BNT162b2 and mRNA-1273 vaccines against SARS-CoV-2 infection and against severe COVID-19, covering primary series and third ...
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        Breaking Barriers: The Promise and Challenges of Immune Checkpoint Inhibitors in Triple-Negative Breast Cancer 

        Said, Sawsan Sudqi; Ibrahim, Wisam Nabeel ( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)
        Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with pronounced immunogenicity, exhibiting rapid proliferation and immune cell infiltration into the tumor microenvironment. TNBC’s heterogeneity poses ...
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        Breast cancer in the GCC countries: A focus on BRCA1/2 and non-BRCA1/2 genes. 

        Rahman, Sumaya; Zayed, Hatem ( Elsevier , 2018 , Article)
        The GCC is an economic alliance of six Arab countries, including Bahrain, Kuwait, Oman, Qatar, Saudi Arabia, and United Arab Emirates (UAE). The rate of endogamous marriage among the GCC countries is approaching 100%, with ...

        مركز المجموعات الرقمية لجامعة قطر هو مكتبة رقمية تديرها مكتبة جامعة قطر بدعم من إدارة تقنية المعلومات

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