Browsing Biomedical Sciences by Title
Now showing items 641-660 of 685
-
Thrombotic and Hypercoagulability Complications of COVID-19: An Update
( Dovepress , 2021 , Article)The current COVID-19 pandemic emerged in December 2019, in China, affecting millions of people worldwide. COVID-19 is mainly a disease of the respiratory system, yet systematic complications have also been reported among ... -
Thymoquinone Suppresses Cell Proliferation and Enhances Apoptosis of HL60 Leukemia Cells through Re-Expression of JAK/STAT Negative Regulators.
( West Asia Organization for Cancer Prevention (WAOCP) , 2021 , Article)The natural compound, thymoquinone (TQ) has demonstrated potential anticancer properties in inhibiting cell proliferation and promoting apoptosis in myeloid leukemia cells, breast cancer cells, and others. However, the ... -
Thymoquinone, as a Novel Therapeutic Candidate of Cancers
( MDPI , 2021 , Article)To date, natural products are widely used as pharmaceutical agents for many human diseases and cancers. One of the most popular natural products that have been studied for anticancer properties is thymoquinone (TQ). As ... -
TLR4 Receptor D299G/T399I Haplotype Polymorphism Is Associated with Insulin Resistance in Obese Female Subjects
(2020 , Article)Background: Activation of Toll-like-receptor 4 (TLR4) causes chronic inflammation that can result in obesity and metabolic syndrome (MeS). Aim: This study aimed to investigate the role of TLR4 polymorphisms of TLR4D299G/T399I, ... -
Total and high molecular weight adiponectin in patients with coronary artery disease
( Wolters Kluwer Health , 2009 , Article)BACKGROUND: Serum adiponectin inversely correlates with the extent of coronary artery disease (CAD). OBJECTIVES: To investigate the clinical significance of measuring high molecular weight (HMW) adiponectin in addition to ... -
Toxicity evaluation of selected ionic liquid compounds on embryonic development of Zebrafish.
( Elsevier , 2018 , Article)Hydrate formation in seafloor pipelines is considered an economic and flow assurance issue for the oil and gas industries. Ionic liquids (ILs) have been recently used as potential hydrate inhibitors. Although branded as ... -
Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model
( MDPI , 2022 , Article)Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate ... -
The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1
( Public Library of Science , 2020 , Article)The SARS-CoV-2 (COVID-19) pandemic is a global crisis that threatens our way of life. As of November 18, 2020, SARS-CoV-2 has claimed more than 1,342,709 lives, with a global mortality rate of ~2.4% and a recovery rate of ... -
Traumatic brain injury: Oxidative stress and novel anti-oxidants such as mitoquinone and edaravone
( MDPI , 2020 , Article Review)Traumatic brain injury (TBI) is a major health concern worldwide and is classified based on severity into mild, moderate, and severe. The mechanical injury in TBI leads to a metabolic and ionic imbalance, which eventually ... -
Trilayer composite scaffold for urethral reconstruction: in vitro evaluation of mechanical, biological, and angiogenic properties
( IOP Publishing , 2024 , Article)Regeneration of damaged urethral tissue remains a major challenge in the field of lower urinary tract reconstruction. To address this issue, various synthetic and natural biodegradable biomaterials are currently being ... -
Tumor reversion: a dream or a reality.
( Pubmed , 2021 , Article)Reversion of tumor to a normal differentiated cell once considered a dream is now at the brink of becoming a reality. Different layers of molecules/events such as microRNAs, transcription factors, alternative RNA splicing, ... -
Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar
( BMJ Publishing Group , 2023 , Article)Objective To assess the evolution of COVID-19 severity and fatality in a unique setting that consistently applied, throughout the pandemic, rigorous and standardised criteria for defining severe COVID-19 outcomes. Methods ... -
Two patients with Canavan disease and structural modeling of a novel mutation.
( Springer US , 2017 , Article)Canavan disease (CD) is a rare fatal childhood neurological autosomal recessive genetic disease caused by mutations in the ASPA gene, which lead to catalytic deficiency of the ASPA enzyme, which catalyzes the hydrolysis ... -
Two prolonged viremic SARS-CoV-2 infections with conserved viral genome for two months
( Elsevier , 2021 , Article)We document two cases of viremic and prolonged active infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) where the viral genome was conserved for two months, but infection was with little or ... -
Uncommon presentation of complicated internal hernia through the appendices epiploicae ring of adhesion: a clinical case study
( Frontiers Media , 2024 , Article)Background: Internal hernias are infrequent, yet serious, medical conditions with potentially severe consequences. An internal hernia resulting from an Appendices epiploicae (AE) ring is an especially rare cause, with a ... -
UNCONVENTIONAL ANIMAL MODELS IN INFECTIOUS DISEASE RESEARCH
( Frontiers , 2021 , E-Book)Apart from genetics and physiology, our understanding of other important aspects of the biological life, such as host-pathogen interactions stayed at its infancy for many years. Back then, many infectious diseases lacked ... -
Understanding Gene Expression and Transcriptome Profiling of COVID-19: An Initiative Towards the Mapping of Protective Immunity Genes Against SARS-CoV-2 Infection.
( Frontiers Media , 2021 , Article)The COVID-19 pandemic has created an urgent situation throughout the globe. Therefore, it is necessary to identify the differentially expressed genes (DEGs) in COVID-19 patients to understand disease pathogenesis and the ... -
Understanding the genetics of early onset obesity in a cohort of children from Qatar.
( Oxford University Press , 2023 , Article)Monogenic obesity is a rare form of obesity due to pathogenic variants in genes implicated in the leptin-melanocortin signaling pathway and accounts for around 5% of severe early onset obesity. Mutations in the genes ... -
Understanding the structure-function relationship of HPRT1 missense mutations in association with Lesch-Nyhan disease and HPRT1-related gout by in silico mutational analysis.
( Elsevier , 2019 , Article)The nucleotide salvage pathway is used to recycle degraded nucleotides (purines and pyrimidines); one of the enzymes that helps to recycle purines is hypoxanthine guanine phosphoribosyl transferase 1 (HGPRT1). Therefore, ... -
Unraveling the Dysbiosis of Vaginal Microbiome to Understand Cervical Cancer Disease Etiology—An Explainable AI Approach
( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)Microbial Dysbiosis is associated with the etiology and pathogenesis of diseases. The studies on the vaginal microbiome in cervical cancer are essential to discern the cause and effect of the condition. The present study ...