Browsing Biomedical Sciences by Title
Now showing items 621-640 of 718
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Spectrum of mutations of cystic fibrosis in the 22 Arab countries: A systematic review.
( Wiley , 2018 , Article)Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, with various clinical manifestations that affect pulmonary, digestive, exocrine and male reproductive functions as well ... -
Spectrum of mutations of familial hypercholesterolemia in the 22 Arab countries.
( Elsevier , 2018 , Article)Familial hypercholesterolemia (FH) is an inherited genetic disorder of lipid metabolism characterized by a high serum LDL-cholesterol profile and xanthoma formation, and FH increases the risk of premature atherosclerosis ... -
The Spectrum of Mutations of Homocystinuria in the MENA Region
( MDPI , 2020 , Article Review)Homocystinuria is an inborn error of metabolism due to the deficiency in cystathionine beta-synthase (CBS) enzyme activity. It leads to the elevation of both homocysteine and methionine levels in the blood and urine. ... -
Strategies to enhance graphic and results interpretation of a regression-based approach for method comparison studies.
( Future Science Ltd , 2017 , Article)To improve the effectiveness of a previous regression-based approach for the assessment of the agreement between different analytical methods, two modifications/integrations to the original scheme by means of log10 ... -
Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach
( Wiley Periodicals, Inc , 2017 , Article)Larsen syndrome (LRS) is a rare genetic disease associated with variable manifestations including skeletal malformations, dislocations of the large joints, and notable changes in facial and limb features. Genetic variants ... -
Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.
( Wiley , 2018 , Article)Galactosemia type 2 is an autosomal recessive disorder characterized by the deficiency of galactokinase (GALK) enzyme due to missense mutations in GALK1 gene, which is associated with various manifestations such as hyper ... -
Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope
( Elsevier (Cell Press) , 2017 , Article)The heavy chain IGHV1-69 germline gene exhibits a high level of polymorphism and shows biased use in protective antibody (Ab) responses to infections and vaccines. It is also highly expressed in several B cell malignancies ... -
Structural modeling of p.V31F variant in the aspartoacylase gene.
( Springer Verlag , 2016 , Article)Aspartoacylase (ASPA) is an abundant enzyme in the brain, which catalyzes the conversion of N-acetylaspartate into acetate and aspartate, deficiency in its activity leads to degeneration of the white matter of the brain ... -
Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2.
( Frontiers Media , 2021 , Article)The number of confirmed COVID-19 cases is rapidly increasing with no direct treatment for the disease. Few repurposed drugs, such as Remdesivir, Chloroquine, Hydroxychloroquine, Lopinavir, and Ritonavir, are being tested ... -
Student perspectives on the integration of artificial intelligence into healthcare services
( SAGE Publications Inc. , 2023 , Article)Background: Healthcare workers are often overworked, underfunded, and face many challenges. Integration of artificial intelligence into healthcare service provision can tackle these challenges by relieving burdens on ... -
Substances Secreted by Starved Human Dermal Fibroblasts Enhancing the Wound Healing Process in Rat without Scar: A Potential Acellular System for Wound Healing
( Hamad Bin Khalifa University Press , 2016 , Conference Paper)Background Despite being a major cellular component of various engineered skin substituent, underlying mechanism of successful fibroblast transplantation in wound healing is not clear. Here we show that substances derived ... -
Substitution impact of highly conserved arginine residue at position 75 in GJB1 gene in association with X-linked Charcot-Marie-tooth disease: A computational study.
( Elsevier , 2018 , Article)X-linked Charcot-Marie-Tooth type 1 X (CMTX1) disease is a subtype of Charcot-Marie-Tooth (CMT), which is mainly caused by mutations in the GJB1 gene. It is also known as connexin 32 (Cx32) that leads to Schwann cell ... -
Sulforaphane Downregulates Hepatic Fibroblast Growth Factor 21 (FGF21) of Diet Induced Obese Mice
( The Obesity Society , 2020 , Conference Paper)Background: Fibroblast growth factor 21 is a hormone-like protein that plays a critical role as an energy regulator. Sulforaphane (SFN) is expected to have potential therapeutic effects in treating obesity. This study aims ... -
Sulforaphane reduces obesity by reversing leptin resistance.
( eLife Sciences Publications , 2022 , Article)The ascending prevalence of obesity in recent decades is commonly associated with soaring morbidity and mortality rates, resulting in increased health-care costs and decreased quality of life. A systemic state of stress ... -
Supervised practice program guided by the Accreditation Council for Education in Nutrition and Dietetics standards improves potential employability of nutrition/dietetics graduates: perspective of employers and preceptors.
( BMC , 2019 , Article)This study investigated employers' perspectives on the impact of a supervised practice program (SPP), guided by international accreditation standards on the skill development and potential employability of dietetics students. ... -
Synthesis and Optimization of a Highly Stable and Efficient BN/TiO2 Nanocomposite for Phenol Degradation: A Photocatalytic, Mechanistic and Environmental Impact Study
( Wiley , 2021 , Article)Different BN/TiO2 nanocomposites were prepared hydrothermally, and their ratio was optimized to get the best photocatalytic performance towards phenol degradation. They were characterized by x-ray photoelectron spectroscopy, ... -
Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles.
( MDPI , 2019 , Article)The development of advanced nanomaterials and technologies is essential in biomedical engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their ... -
Synthesis, characterization, and antimicrobial properties of novel double layer nanocomposite electrospun fibers for wound dressing applications
( Dove Press , 2017 , Article)Herein, novel hybrid nanomaterials were developed for wound dressing applications with antimicrobial properties. Electrospinning was used to fabricate a double layer nanocomposite nanofibrous mat consisting of an upper ... -
The synthetic cannabinoids menace: a review of health risks and toxicity
( Springer Nature , 2024 , Article)Synthetic cannabinoids (SCs) are chemically classified as psychoactive substances that target the endocannabinoid system in many body organs. SCs can initiate pathophysiological changes in many tissues which can be severe ... -
A systematic investigation of the bio-toxicity of core-shell magnetic mesoporous silica microspheres using zebrafish model
( Elsevier , 2018 , Article)Abstract In this work, shearing interface coassembly in biliquid phase systems is employed to synthesize biocompatible core-shell magnetic mesoporous silica microspheres with uniform size of about 600 nm, perpendicular ...