Browsing Biomedical Sciences by Type "Article"
Now showing items 1-20 of 568
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3D culture of cancer cells in alginate hydrogel beads as an effective technique for emergency cell storage and transportation in the pandemic era
( Wiley , 2021 , Article)Due to the restrictions in access to research lab during the pandemic time and due to existence of challenges in providing proper storage and transportation of cells in developing countries, having an effective and feasible ... -
7-O-methylpunctatin, a novel homoisoflavonoid, inhibits phenotypic switch of human arteriolar smooth muscle cells
( MDPI AG , 2019 , Article)Remodeling of arterioles is a pivotal event in the manifestation of many inflammation-based cardio-vasculopathologies, such as hypertension. During these remodeling events, vascular smooth muscle cells (VSMCs) switch from ... -
A Comparison Study in the Management of Ectopic Pregnancy between State of Qatar and Kingdom of Bahrain
( Hamad bin Khalifa University Press (HBKU Press) , 2007 , Article)Ectopic pregnancy is of increasing concern to gynecologists since it is a major cause of maternal mortality and morbidity in reproductive age women. It occurs when the conceptus implants in an abnormal position other than ... -
A cross-sectional study on the impact of the COVID-19 pandemic on psychological outcomes: Multiple indicators and multiple causes modeling
( Public Library of Science , 2022 , Article)Although the psychological impact of coronavirus disease 2019 (COVID-19) has been evaluated in the literature, further research is needed, particularly on post-traumatic stress disorder (PTSD) and psychological outcomes, ... -
A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation
( Taylor and Francis Ltd. , 2023 , Article)Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by insufficient aspartylglucosaminidase (AGA) activity leading to chronic neurodegeneration. We utilized the PhosphoSitePlus tool to identify the AGA ... -
A population study of clinically actionable genetic variation affecting drug response from the Middle East
( Nature Research , 2022 , Article)Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ... -
Aberrant DNA methylation of PTPRG as one possible mechanism of its under-expression in CML patients in the State of Qatar
( Wiley Open Access , 2020 , Article)Several studies showed that aberrant DNA methylation is involved in leukemia and cancer pathogenesis. Protein tyrosine phosphatase receptor gamma (PTPRG) expression is a natural inhibitory mechanism that is downregulated ... -
ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review
( Elsevier , 2021 , Article)Introduction The SARS-CoV-2 pandemic has been affecting the health and economic, as well as social, life of the entire globe since the end of 2019. The virus causes COVID-19, with a wide range of symptoms among the infected ... -
Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches.
( BMC , 2024 , Article)The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ... -
Accredited genetic testing in the Arab Gulf region: reinventing the wheel.
( Nature Publishing Group , 2016 , Article)Accredited genetic testing in the Arab Gulf region: reinventing the wheel. -
Actionable genomic variants in 6045 participants from the Qatar Genome Program
(2021 , Article)In a clinical setting, DNA sequencing can uncover findings unrelated to the purpose of genetic evaluation. The American College of Medical Genetics and Genomics (ACMG) recommends the evaluation and reporting of 59 genes ... -
Activation of the pro-oxidant PKC?IIp66Shc Signaling pathway contributes to pericyte dysfunction in skeletal muscles of patients with diabetes with critical limb Ischemia
( American Diabetes Association Inc. , 2016 , Article)Critical limb ischemia (CLI), foot ulcers, former amputation, and impaired regeneration are independent risk factors for limb amputation in subjects with diabetes. The present work investigates whether and by which mechanism ... -
Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia
( American Diabetes Association , 2016 , Article)Critical limb ischemia (CLI), foot ulcers, former amputation and impaired regeneration are independent risk factors for limb amputation in diabetic subjects. The present work investigates whether and by which mechanism ... -
Addressing bias in the definition of SARS-CoV-2 reinfection: implications for underestimation
( Frontiers Media , 2024 , Article)Introduction: Reinfections are increasingly becoming a feature in the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, accurately defining reinfection poses methodological ... -
Adiponectin Ameliorates Hyperglycemia-Induced Retinal Endothelial Dysfunction, Highlighting Pathways, Regulators, and Networks
( dovepress , 2022 , Article)Background: The pathophysiology of diabetic retinopathy (DR) is multifaced. A low level of circulating adiponectin (APN) in type 2 diabetes is associated with microvasculature complications, and its role in the evolution ... -
Adipose tissue dysfunction in cancer cachexia
( Wiley Periodicals, Inc. , 2018 , Article)Cancer cachexia is a complex disorder that is driven by inflammation and metabolic imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer cachexia, is an essential metabolic and secretory ... -
Adult appendicitis score versus Alvarado score: A comparative study in the diagnosis of acute appendicitis
( Elsevier , 2023 , Article)Background Acute Appendicitis (AA) is the most common abdominal surgical emergency. It requires proper management to decrease mortality and morbidity. Clinical scoring systems for diagnosing AA aimed to decrease the use ... -
AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos
( SpringerOpen , 2020 , Article)© 2020, The Author(s). Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. ... -
Airway and Oral microbiome profiling of SARS-CoV-2 infected asthma and non-asthma cases revealing alterations-A pulmonary microbial investigation
( NLM (Medline) , 2023 , Article)New evidence strongly discloses the pathogenesis of host-associated microbiomes in respiratory diseases. The microbiome dysbiosis modulates the lung's behavior and deteriorates the respiratory system's effective functioning. ... -
Akkermansia, a possible microbial marker for poor glycemic control in qataris children consuming arabic diet—a pilot study on pediatric t1dm in qatar
( MDPI , 2021 , Article)In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, ...
