Search
Now showing items 131-140 of 140
The mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy
(
MDPI
, 2020 , Article)
Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; ...
Antibody Response to SARS-CoV-2: A Cohort Study in Qatar's Primary Care Settings.
(
SAGE Publications
, 2021 , Article)
Globally, countries are rolling out Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) quarantine policies and vaccination programs. Research studies are needed in helping understand the likelihood of acquired ...
Diagnostic Efficiency of Three Fully Automated Serology Assays and Their Correlation with a Novel Surrogate Virus Neutralization Test in Symptomatic and Asymptomatic SARS-COV-2 Individuals
(
MDPI
, 2020 , Article)
Abstract: To support the deployment of serology assays for population screening during the
COVID-19 pandemic, we compared the performance of three fully automated SARS-CoV-2 IgG assays: Mindray CL-900i® (target: spike [S] ...
The prevalence of HEV among non-A-C hepatitis in Qatar and efciency of serological markers for the diagnosis of hepatitis E
(
BMC
, 2021 , Article)
Background: The rapid growth of Qatar in the last two decades has attracted a large influx of immigrant workers
who mostly come from HEV-hyperendemic countries. Thus, we aim to investigate the prevalence of HEV among acute ...
The impact of microbial composition on postprandial glycaemia and lipidaemia: A systematic review of current evidence
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
Postprandial hyperglycaemia is associated with increased risk of cardiovascular disease. Recent studies highlight the role of the gut microbiome in influencing postprandial glycaemic (PPG) and lipidaemic (PPL) responses. ...
The role of polymorphisms in vitamin d-related genes in response to vitamin d supplementation
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2020 , Article)
Background. Vitamin D deficiency represents a major healthcare problem. Vitamin D status is influenced by genetic and environmental determinants. Several observational studies have evaluated the association of single-nucleotide ...
Immunomodulatory effects of vitamin d supplementation in a deficient population
(
Multidisciplinary Digital Publishing Institute (MDPI)
, 2021 , Article)
In addition to its canonical functions, vitamin D has been proposed to be an important mediator of the immune system. Despite ample sunshine, vitamin D deficiency is prevalent (>80%) in the Middle East, resulting in a high ...
Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia
(
Elsevier
, 2020 , Article)
Propionic Acidemia (PA) is an inborn error of metabolism caused by variants in the or genes, leading to mitochondrial accumulation of propionyl-CoA and its by-products. Here, we report a 2 year-old Egyptian boy with PA ...
A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease
(
Elsevier
, 2021 , Article)
The World Health Organization declared Ebola virus disease(EVD) as the major outbreak in the 20th century. EVD was firstidentified in 1976 in South Sudan and the Democratic Republicof the Congo. EVD was transmitted from ...
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes
(
Nature Research
, 2021 , Article)
Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ...