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Now showing items 11-20 of 21
Comparative computational assessment of the pathogenicity of mutations in the Aspartoacylase enzyme
(
Springer US
, 2017 , Article)
Aspartoacylase (ASPA) is a zinc-dependent abundant enzyme in the brain, which catalyzes the conversion of N-acetyl aspartate (NAA) into acetate and aspartate. Mutations in the ASPA gene are associated with the development ...
Nanodiagnostics for tuberculosis detection
(
Taylor & Francis
, 2017 , Article)
Introduction
Tuberculosis (TB) is a leading killer worldwide. End TB strategy aims at ending the TB epidemic by 2030. Early, accurate, and affordable diagnosis represents a cornerstone to achieve this goal. Innovative ...
Combine iron Chelation therapy ameliorates decline of iron on iron loaded Zebrafish embryo
(2017 , Conference Proceedings)
Thalassemia is the most common genetically inherited blood disorder in the world arisen
from defect in hemoglobin production, resulting in ineffective erythropoiesis and rapid destruction
of RBC in the periphery that ...
Cellular immune activation in Sardinian middle-aged, older adults and centenarians
(
Elsevier
, 2017 , Article)
In addition to viral infections, malignant disorders, autoimmune diseases, and allograft rejection episodes, neopterin increases in older people where it is found to be predictive of overall mortality. Thus, the serum ...
Genotype-phenotype correlation in 18 Egyptian patients with glutaric acidemia type I
(
Springer US
, 2017 , Article)
Glutaric acidemia I (GAI) is an autosomal recessive metabolic disease caused by a deficiency of glutaryl-CoA dehydrogenase enzyme (GCDH). Patients with GAI are characterized by macrocephaly, acute encephalitis-like crises, ...
Taxane formulations: From plant to clinic
(
Springer International Publishing
, 2017 , Book chapter)
Taxanes including paclitaxel and docetaxel are highly active against many types of cancers. The main obstacle with developing delivery systems of taxanes is their poor water solubility. In this chapter, taxanes were reviewed ...
Seroprevalence and incidence of hepatitis E virus among blood donors: A review.
(
Wiley
, 2017 , Article)
Hepatitis E virus (HEV) is an RNA virus with 4 main genotypes. HEV-1 and HEV-2 infect solely humans, while HEV-3 and HEV-4 infect humans and various animals such as pigs, deer, and rabbits. HEV-5 and HEV-6 infect mainly ...
Prevention of oral cancer
(
Springer International Publishing
, 2017 , Book chapter)
Oral cancer has become a major debilitating incidence in both genders alike. Oral cancer, a part of head and neck cancer, is a combination of two types of cancer: oral cavity cancer and oropharyngeal cancer. The most common ...
Cysteamine revisited: repair of arginine to cysteine mutations.
(
Springer Verlag
, 2017 , Article)
Cysteamine is a small aminothiol endogenously derived from coenzyme A degradation. For some decades, synthetic cysteamine has been employed for the treatment of cystinosis, and new uses of the drug continue to emerge. In ...
Antitumor Activities of the Novel Isosteviol Derivative 10C Against Liver Cancer
(
International Institute of Anticancer Research
, 2017 , Article)
Background/Aim. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and the fifth most common primary malignancy with worldwide increasing incidence. The current study aims to investigate the anticancer ...