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    A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation causing breast cancer. 

    Thirumal Kumar, D; Jain, Nikita; Evangeline, Judith; Kamaraj, Balu; Siva, R; Zayed, Hatem; George Priya Doss, C... more authors ... less authors ( Elsevier , 2019 , Article)
    Breast cancer (BC) is the most commonly diagnosed cancer among females worldwide, and among the BC-associated mutations in various proteins, mutations in the RAC-alpha serine/threonine-protein kinase (AKT1) remain the most ...
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    Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach. 

    Thirumal Kumar, D; Jain, Nikita; S, Udhaya Kumar; GeorgePriya Doss, C; Zayed, Hatem ( Taylor & Francis , 2019 , Article)
    The autosomal recessive phosphomannomutase 2-congenital disorder of glycosylation (PMM2-CDG) is characterized by defective functioning of the PMM2 enzyme, which is necessary for the conversion of mannose-6-phosphate into ...
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    A comparative computational approach toward pharmacological chaperones (NN-DNJ and ambroxol) on N370S and L444P mutations causing Gaucher's disease. 

    Thirumal Kumar, D; Iyer, Sharada; Christy, J Priyadharshini; Siva, R; Tayubi, Iftikhar Aslam; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Book chapter)
    Gaucher's disease (GD) is the most commonly known lysosomal disorder that occurs due to mutations in the β-glucocerebrosidase (GBA) protein. Our previous findings (Thirumal Kumar, Eldous, Mahgoub, George Priya Doss, Zayed, ...
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    Computational modelling approaches as a potential platform to understand the molecular genetics association between Parkinson's and Gaucher diseases. 

    Thirumal Kumar, D; Eldous, Hend Ghasan; Mahgoub, Zainab Alaa; George Priya Doss, C; Zayed, Hatem ( Springer , 2018 , Article)
    Gaucher's disease (GD) is a genetic disorder in which glucocerebroside accumulates in cells and specific organs. It is broadly classified into type I, type II and type III. Patients with GD are at high risk of Parkinson's ...
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    Computational and modeling approaches to understand the impact of the Fabry's disease causing mutation (D92Y) on the interaction with pharmacological chaperone 1-deoxygalactonojirimycin (DGJ). 

    Thirumal Kumar, D; Judith, E; Priyadharshini Christy, J; Siva, R; Tayubi, Iftikhar Aslam; Chakraborty, Chiranjib; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2019 , Book chapter)
    Fabry's disease (FD) is the second most commonly occurring lysosomal storage disorders (LSDs). The mutations in α-galactosidase A (GLA) protein were widely found to be causative for the Fabry's disease. These mutations ...
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    Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2. 

    Thirumal Kumar, D; Jerushah Emerald, L; George Priya Doss, C; Sneha, P; Siva, R; Charles Emmanuel Jebaraj, W; Zayed, Hatem... more authors ... less authors ( Springer US , 2018 , Article)
    The 2-hydroxyglutaric aciduria (2-HGA) is a rare neurometabolic disorder that leads to the development of brain damage. It is classified into three categories: D-2-HGA, L-2-HGA, and combined D,L-2-HGA. The D-2-HGA includes ...
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    Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene. 

    Udhaya Kumar, S; Thirumal Kumar, D; Mandal, Pinky D; Sankar, Srivarshini; Haldar, Rishin; Kamaraj, Balu; Walter, Charles Emmanuel Jebaraj; R, Siva; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Elsevier , 2020 , Article)
    Sjögren-Larsson syndrome (SLS) is an autoimmune disorder inherited in an autosomal recessive pattern. To date, 80 missense mutations have been identified in association with the Aldehyde Dehydrogenase 3 Family Member A2 ...
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    Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome. 

    Thirumal Kumar, D; Udhaya Kumar, S; Nishaat Laeeque, Ahmed Shaikh; Apurva Abhay, Shivalkar; Bithia, R; Magesh, R.; Kumar, Maignana; Zayed, Hatem; George Priya Doss, C... more authors ... less authors ( Elsevier , 2020 , Article)
    Blau syndrome (BS), which affects the eyes, skin, and joints, is an autosomal dominant genetic inflammatory disorder. BS is caused by mutations in the NOD2 gene. However, there are no direct treatments, and treatment with ...
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    Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients - A Bioinformatics Approach. 

    Udhaya Kumar, S; Thirumal Kumar, D; Siva, R; George Priya Doss, C; Younes, Salma; Younes, Nadin; Sidenna, Mariem; Zayed, Hatem... more authors ... less authors ( Frontiers Media , 2020 , Article)
    Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disorder that is clinically complex and has increased production of autoantibodies. Via emerging technologies, researchers have identified genetic variants, ...
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    Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach. 

    Udhaya Kumar, S; Thirumal Kumar, D; Bithia, R; Sankar, Srivarshini; Magesh, R.; Sidenna, Mariem; George Priya Doss, C; Zayed, Hatem... more authors ... less authors ( Frontiers Media , 2020 , Article)
    Familial hypercholesterolemia (FH) is one of the major risk factor for the progression of atherosclerosis and coronary artery disease. This study focused on identifying the dysregulated molecular pathways and core genes ...
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    Author
    • Thirumal Kumar, D (16)
    • Zayed, Hatem (16)
    • George Priya Doss, C (15) Udhaya Kumar, S (5) ... View More
    Type
      Article (14) Book chapter (2)
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      Molecular dynamics (6) Molecular docking (4) Variant classification (4) expression profiling data (2) ... View More
    Publication Date
      2019 (7) 2020 (6) 2018 (3)
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      2019 (9) 2020 (6) 2018 (1)
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