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JC-10 probe as a novel method for analyzing the mitochondrial membrane potential and cell stress in whole zebrafish embryos

Younes, Nadin; Alsahan, Bana S.; Al-Mesaifr, Asmaa J.; Da'as, Sahar I.; Pintus, Gianfranco; ... more authors ... less authors ( Oxford University Press , 2021 , Article)

Background: A sensitive method to investigate cellular stress and cytotoxicity is based on measuring mitochondrial membrane potential. Recently, JC-10, was developed to measure mitochondrial membrane potential in vitro and ...

Non-coding RNAs as biomarkers of myocardial infarction

Almaghrbi, Heba; Giordo, Roberta; Pintus, Gianfranco; Zayed, Hatem ( Elsevier , 2023 , Article)

Non-coding RNAs (ncRNAs) encompass a family of ubiquitous RNA molecules that lack protein-coding potential and have tissue-specific expression. A significant body of evidence indicates that ncRNA's aberrant expression plays ...

Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells

Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; ... more authors ... less authors ( Taylor & Francis , 2022 , Article)

Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ...

The mitochondria: A target of polyphenols in the treatment of diabetic cardiomyopathy

Bhagani, Humna; Nasser, Suzanne A.; Dakroub, Ali; El-Yazbi, Ahmed F.; Eid, Assaad A.; ... more authors ... less authors ( MDPI , 2020 , Article)

Diabetic cardiomyopathy (DCM) is a constellation of symptoms consisting of ventricular dysfunction and cardiomyocyte disarray in the presence of diabetes. The exact cause of this type of cardiomyopathy is still unknown; ...

Herbal medicine for slowing aging and aging-associated conditions: Efficacy, mechanisms and safety

Phu, Hoa T.; Thuan, Duong T.B.; Nguyen, Thi H.D.; Posadino, Anna M.; Eid, Ali H.; ... more authors ... less authors ( Bentham , 2020 , Article)

Aging and aging-associated diseases are issues with unsatisfactory answers in the medical field. Aging causes important physical changes which, even in the absence of the usual risk factors, render the cardiovascular system ...

Nox2 activity is required in obesity-mediated alteration of bone remodeling

Rahman, Md Mizanur; El Jamali, Amina; Halade, Ganesh V.; Ouhtit, Allal; Abou-Saleh, Haissam; ... more authors ... less authors ( Hindawi Limited , 2018 , Article)

Despite increasing evidence suggesting a role for NADPH oxidases (Nox) in bone pathophysiology, whether Nox enzymes contribute to obesity-mediated bone remodeling remains to be clearly elucidated. Nox2 is one of the ...

High-sensitive detection and quantitation of thyroid-stimulating hormone (TSH) from capillary/fingerstick and venepuncture whole-blood using fluorescence-based rapid lateral flow immunoassay (LFIA)

Samar, Shurbaji; Al Tamimi, Faleh; Al Ghwairi, Mahmoud M.; El Chaar, Dayana; Younes, Salma; ... more authors ... less authors ( Elsevier , 2023 , Article)

BackgroundIn the last decade, point of care testing (POCT) such as lateral flow immunoassays (LFIA) were developed for rapid TSH measurement. Most of these TSH-LFIAs are designed for qualitative measurements (i.e., if TSH ...

Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis

Ramli, Iman; Cheriet, Thamere; Posadino, Anna Maria; Giordo, Roberta; Zayed, Hatem; ... more authors ... less authors ( IMR Press Limited , 2023 , Article)

Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring ...

MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.

Dehaini, Hassan; Awada, Hussein; El-Yazbi, Ahmed; Zouein, Fouad A; Issa, Khodr; ... more authors ... less authors ( MDPI , 2019 , Article)

Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), ...

Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model.

Al-Kandari, Halema; Younes, Nadin; Al-Jamal, Ola; Zakaria, Zain Z; Najjar, Huda; ... more authors ... less authors ( MDPI , 2019 , Article)

Advanced oxidation processes (AOPs) have recently attracted great interest in water pollution management. Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen ...