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Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model.

Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; ... more authors ... less authors ( MDPI , 2022 , Article)

Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ...

JC-10 probe as a novel method for analyzing the mitochondrial membrane potential and cell stress in whole zebrafish embryos

Younes, Nadin; Alsahan, Bana S.; Al-Mesaifr, Asmaa J.; Da'as, Sahar I.; Pintus, Gianfranco; ... more authors ... less authors ( Oxford University Press , 2021 , Article)

Background: A sensitive method to investigate cellular stress and cytotoxicity is based on measuring mitochondrial membrane potential. Recently, JC-10, was developed to measure mitochondrial membrane potential in vitro and ...

Effect of Water-Pipe Smoking on the Normal Development of Zebrafish

Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; ... more authors ... less authors ( MDPI , 2021 , Article)

Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ...

Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model

Zakaria, Zain Z; Mahmoud, Nouf N; Benslimane, Fatiha M; Yalcin, Huseyin C.; Al Moustafa, Ala-Eddin; ... more authors ... less authors ( American Chemical Society , 2022 , Article)

Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ...

Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model

Sokary, Sara; Zakaria, Zain; Bawadi, Hiba; Al-Asmakh, Maha ( MDPI , 2023 , Article)

Cancer is the second leading cause of death worldwide, and triple-negative breast cancer (TNBC) patients show the poorest prognosis and survival and the highest metastasis prevalence among all breast cancer subtypes. Matcha ...

Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model.

Al-Kandari, Halema; Younes, Nadin; Al-Jamal, Ola; Zakaria, Zain Z; Najjar, Huda; ... more authors ... less authors ( MDPI , 2019 , Article)

Advanced oxidation processes (AOPs) have recently attracted great interest in water pollution management. Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen ...

Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model

Abou-Saleh, Haissam; Younes, Nadin; Rasool, Kashif; Younis, Manaf H.; Prieto, Rafael M.; ... more authors ... less authors ( MDPI , 2019 , Article)

The use of chitosan nanoparticles (ChNPs) in various biological and environmental applications is attracting great interest. However, potential side effects related to ChNP toxicity remain the major limitation hampering ...

Zebrafish larvae as a model to demonstrate secondary iron overload.

Nasrallah, Gheyath K; Younes, Nadin N; Baji, Missbah H; Shraim, Amjad M; Mustafa, Ibrahim ( Wiley , 2018 , Article)

Thalassemia is the most common genetically inherited blood disorder arising from a defect in hemoglobin production, resulting in ineffective erythropoiesis and severe hemolytic anemia. While transfusion therapy corrects ...

Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)

Giordo, Roberta; Nasrallah, Gheyath; Al-Jamal, Ola; Paliogiannis, Panagiotis; Pintus, Gianfranco ( MDPI , 2020 , Article)

Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. ...

Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish

Da'as, Sahar I; Thanassoulas, Angelos; Calver, Brian L; Beck, Konrad; Salem, Rola; ... more authors ... less authors ( Wiley , 2019 , Article)

Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. ...