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    Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model. 

    Al-Thani, Hissa F; Shurbaji, Samar; Zakaria, Zain Zaki; Hasan, Maram H; Goracinova, Katerina; Korashy, Hesham M; Yalcin, Huseyin C... more authors ... less authors ( MDPI , 2022 , Article)
    Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells' proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their ...
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    JC-10 probe as a novel method for analyzing the mitochondrial membrane potential and cell stress in whole zebrafish embryos 

    Younes, Nadin; Alsahan, Bana S.; Al-Mesaifr, Asmaa J.; Da'as, Sahar I.; Pintus, Gianfranco; Majdalawieh, Amin F.; Nasrallah, Gheyath K.... more authors ... less authors ( Oxford University Press , 2021 , Article)
    Background: A sensitive method to investigate cellular stress and cytotoxicity is based on measuring mitochondrial membrane potential. Recently, JC-10, was developed to measure mitochondrial membrane potential in vitro and ...

    Effect of Water-Pipe Smoking on the Normal Development of Zebrafish 

    Zakaria, Zain Zaki; Aladwi, Shaima Ahmad; Benslimane, Fatiha; Al-Absi, Enas S.; Al-Shafai, Mashael; Yalcin, Huseyin C.; Khalil, Ashraf; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( MDPI , 2021 , Article)
    Background: Among all types of tobacco consumption,Water-Pipe Smoking (WPS) is the most widely used in the Middle East and second-most in several other countries. The effect of WPS on normal development is not yet fully ...
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    Developmental Toxicity of Surface-Modified Gold Nanorods in the Zebrafish Model 

    Zakaria, Zain Z; Mahmoud, Nouf N; Benslimane, Fatiha M; Yalcin, Huseyin C.; Al Moustafa, Ala-Eddin; Al-Asmakh, Maha... more authors ... less authors ( American Chemical Society , 2022 , Article)
    Background: nanotechnology is one of the fastest-growing areas, and it is expected to have a substantial economic and social impact in the upcoming years. Gold particles (AuNPs) offer an opportunity for wide-ranging ...
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    Testing the Anticancer Effect of Matcha Using Zebrafish as an Animal Model 

    Sokary, Sara; Zakaria, Zain; Bawadi, Hiba; Al-Asmakh, Maha ( MDPI , 2023 , Article)
    Cancer is the second leading cause of death worldwide, and triple-negative breast cancer (TNBC) patients show the poorest prognosis and survival and the highest metastasis prevalence among all breast cancer subtypes. Matcha ...
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    Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model. 

    Al-Kandari, Halema; Younes, Nadin; Al-Jamal, Ola; Zakaria, Zain Z; Najjar, Huda; Alserr, Farah; Pintus, Gianfranco; Al-Asmakh, Maha A; Abdullah, Aboubakr M; Nasrallah, Gheyath K... more authors ... less authors ( MDPI , 2019 , Article)
    Advanced oxidation processes (AOPs) have recently attracted great interest in water pollution management. Using the zebrafish embryo model, we investigated the environmental impacts of two thermally (RGOTi)- and hydrogen ...
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    Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model 

    Abou-Saleh, Haissam; Younes, Nadin; Rasool, Kashif; Younis, Manaf H.; Prieto, Rafael M.; Yassine, Hadi M.; Mahmoud, Khaled A.; Pintus, Gianfranco; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2019 , Article)
    The use of chitosan nanoparticles (ChNPs) in various biological and environmental applications is attracting great interest. However, potential side effects related to ChNP toxicity remain the major limitation hampering ...
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    Zebrafish larvae as a model to demonstrate secondary iron overload. 

    Nasrallah, Gheyath K; Younes, Nadin N; Baji, Missbah H; Shraim, Amjad M; Mustafa, Ibrahim ( Wiley , 2018 , Article)
    Thalassemia is the most common genetically inherited blood disorder arising from a defect in hemoglobin production, resulting in ineffective erythropoiesis and severe hemolytic anemia. While transfusion therapy corrects ...
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    Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio) 

    Giordo, Roberta; Nasrallah, Gheyath; Al-Jamal, Ola; Paliogiannis, Panagiotis; Pintus, Gianfranco ( MDPI , 2020 , Article)
    Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. ...
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    Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish 

    Da'as, Sahar I; Thanassoulas, Angelos; Calver, Brian L; Beck, Konrad; Salem, Rola; Saleh, Alaaeldin; Kontogianni, Iris; Al-Maraghi, Ali; Nasrallah, Gheyath K; Safieh-Garabedian, Bared; Toft, Egon; Nounesis, George; Lai, F Anthony; Nomikos, Michail... more authors ... less authors ( Wiley , 2019 , Article)
    Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. ...
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      Al-Asmakh, Maha (3) Nasrallah, Gheyath K (3) Pintus, Gianfranco (3) Yalcin, Huseyin C. (3) ... View More
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