Biomedical Sciences: المرسلات الحديثة
السجلات المعروضة 1 -- 20 من 829
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Diet-induced mechanical stress promotes immune and metabolic alterations in the Drosophila melanogaster digestive tract
( Elsevier , 2025 , Article)A fundamental query in immunology is how cells recognize danger in the tissue milieu. For many years, standpoints were mainly centered around damaged cells or structures of invading pathogens, like lipopolysaccharide, being ... -
The role of soluble CD40L in autoimmune diseases
( Elsevier , 2025 , Article)CD40−CD40L is essential for immune system modulation because it coordinates both adaptive and inflammatory responses.Systemic lupus erythematosus, multiple sclerosis, inflammatory bowel disease, thrombocytopenic purpura, ... -
Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity
( Microbiology Society , 2025 , Article)Introduction. Pre-existing immunity to human coronaviruses (HCoVs) may shape the immune response in COVID-19 patients. Increasing evidence suggests that immune cross-reactivity between SARS-CoV-2 and other coronaviruses ... -
Antibody-dependent enhancement of SARS-CoV-2, the impact of variants and vaccination
( Taylor and Francis Group , 2025 , Article)This study characterized antibody-dependent enhancement (ADE) in serum samples from individuals exposed to SARS-CoV-2 via infection or vaccination and evaluated its association with SARS-CoV-2 variants (Wuhan and Omicron), ... -
The impact of pre-existing immunity on the emergence of within-host immune-escape mutations in Omicron lineages
( Microbiology Society , 2025 , Article)The Omicron variant of SARS-CoV-2 circulating amongst highly immunized populations is anticipated to induce immunological pressures, potentially compromising existing immunity. This study investigates vaccine-induced ... -
Glucosamine Schiff bases as fluorescent sensors for recognition of Al+3 and Zn+2 ions
( Elsevier , 2025 , Article)Glucosamine salicylidene (GAS) and Glucosamine-4-nitrosalicylidene (GANS) were synthesized using microwave and investigated as water-soluble chemosensors for aluminum and zinc ions. UV–vis, fluorescence titration, binding ... -
Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer
( John Wiley & Sons , 2025 , Article)Background: Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can ... -
Current epidemiological status of mosquito-borne arboviruses in Gulf countries: a systematic review and meta-analysis
( Springer Nature , 2025 , Article)Background: Mosquito-borne viral (MBV) infections caused by dengue virus (DENV), Rift Valley fever virus (RVFV), West Nile virus (WNV), and chikungunya virus (CHIKV) pose a significant global public health concern. The aim ... -
Role of Exosome in Solid Cancer Progression and Its Potential Therapeutics in Cancer Treatment
( John Wiley & Sons , 2025 , Article)Background: Exosomes are extracellular vesicles ranging from 40 to 100 nm in diameter that mediate intercellular communication by transferring proteins, lipids, nucleic acids, and other metabolites. In the context of cancer, ... -
Cardio-Rheumatic Diseases: Inflammasomes Behaving Badly
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Cardio-rheumatology is an evolving and interdisciplinary field lying at the intersection of rheumatology and cardiovascular medicine that recognizes that individuals with autoimmune and inflammatory rheumatic complications ... -
Exploring endothelial dysfunction in major rheumatic diseases: current trends and future directions
( Springer Science and Business Media Deutschland GmbH , 2025 , Article Review)The relationship between rheumatic diseases (RDs) and endothelial dysfunction (ED) is intricate and multifaceted, with chronic inflammation and immune system dysregulation playing key roles. RDs, including Osteoarthritis ... -
Medicinal Phytocompounds as Potential Inhibitors of p300-HIF1? Interaction: A Structure-Based Screening and Molecular Dynamics Simulation Study
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Background: Hypoxia plays a key role in cancer progression, mainly by stabilizing and activating hypoxia-inducible factor-1 (HIF-1). For HIF-1 to function under low oxygen conditions, it must interact with the transcriptional ... -
Protection conferred by SARS-CoV-2 infection across a spectrum of reinfection symptoms and severities
( BMJ Publishing Group , 2025 , Article)Background SARS-CoV-2 infection is associated with protection against reinfection. This study analysed this protection across different reinfection symptoms and severities, comparing the preomicron and omicron eras. Methods ... -
Integrating pharmacogenomics in three Middle Eastern countries' healthcare (Lebanon, Qatar, and Saudi Arabia): Current insights, challenges, and strategic directions
( Public Library of Science , 2025 , Article)Background and objectives Pharmacogenomics (PGx) leverages genomic information to tailor drug therapies, enhancing precision medicine. Despite global advancements, its implementation in Lebanon, Qatar, and Saudi Arabia ... -
Therapeutic potential and challenges of mesenchymal stem cells in neurological disorders: A concise analysis
( Oxford University Press , 2025 , Article)Neurological diseases comprise a wide array of conditions affecting both the central and peripheral nervous systems. Neurodegenerative diseases encompass a group of debilitating and often fatal neurological disorders for ... -
Spectrum of genetic variants associated with maple syrup urine disease in the Middle East, North Africa, and Türkiye (MENAT): a systematic review
( BioMed Central Ltd , 2025 , Article)Background Maple syrup urine disease (MSUD) is a hereditary metabolic disorder caused by a deficiency in the branched-chain α-keto acid dehydrogenase (BCKD) enzymatic complex. The Middle East and North Africa, and Türkiye ... -
Prevalence of hepatitis C virus infection in Qatar's resident population based on a national screening campaign
( Nature Research , 2025 , Article)Hepatitis C virus (HCV) infection poses a global health challenge, yet its epidemiology in Qatar remains underexplored. This study estimated HCV antibody (Ab) prevalence in Qatar and examined associated socio-demographic ... -
Artificial Intelligence in Bacterial Infections Control: A Scoping Review
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article Review)Background/Objectives: Artificial intelligence has made significant strides in healthcare, contributing to diagnosing, treating, monitoring, preventing, and testing various diseases. Despite its broad adoption, clinical ... -
Accre 8 emerging point of care CLIA system for vitamin B12 assessment compared with three established assays
( Nature Research , 2025 , Article)Accurate Vitamin B12 (Vit B12) quantification is essential for diagnosing deficiencies linked to neurological and hematological disorders. The Accre 8 Point-of-Care (POC) Chemiluminescent Immunoassay (CLIA) system offers ... -
Indoleacetylglutamine Pathway Is a Potential Biomarker for Cardiovascular Diseases
( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality. Metabolomics allows for the identification of important biomarkers for CVDs, essential for early detection and risk assessment. This ...
