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Investigating the Validity and Significance of Variant Calls by Next Generation Sequencing (NGS)
(Biomedical Sciences, 2016 , Master Thesis)
Whole genome or exome sequencing enables the fast generation of large volumes of data and is currently a hot topic in research. This technique has the subject of extensive research and has vast applications in healthcare ...
IN-DEPTH CHARACTERIZATION OF MESENCHYMAL STEM CELLS-DERIVED EXTRACELLULAR VESICLES USING QUANTITATIVE PROTEOMICS
(Biomedical Sciences, 2016 , Master Thesis)
As they home in on injured tissue, modulate the immune system and support tissue repairing, mesenchymal stem cells (MSCs) are considered a promising tool for many therapeutic applications. In vitro, MSCs have been shown ...
EFFECT OF ENDOPLASMIC RETICULUM STRESS MEDIATED BY HYPERGLYCEMIA ON BARRIER FUNCTION IN RETINAL CELLS
(Biomedical Sciences, 2016 , Master Thesis)
Background: Diabetic Retinopathy (DR) is an inflammatory disease mainly characterized by the dysfunction of the retinal blood vessels. Several studies reported a possible link between the hyperglycemia and the activation ...
SEROPREVALENCE AND PHYLOGENETIC GENOTYPING OF EPSTEIN BARR VIRUS (EBV) AMONG BLOOD DONORS IN QATAR
(Biomedical Sciences, 2016 , Master Thesis)
Background: EBV is a lymphotropic herpesvirus and the causative agent of infectious mononucleosis. EBV is highly prevalent and has been linked to several malignancies. The virus is generally transferred by oral secretions ...
Seroprevalence of Anti-Mers-CoV IgG in two groups of Qatar population: Blood donors and case contacts
(Biomedical Sciences, 2017 , Master Thesis)
Since its first isolation in September 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) has diffused across 27 countries infecting more than 1910 individuals with a high case fatality rate. However, MERS-CoV ...
TRANSCRIPTIONAL CHANGES OF MYCOPLASMA CONTAMINATION IN GENE EXPRESSION STUDIES
(Biomedical Sciences, 2016 , Master Thesis)
Mycoplasma, the smallest self-replicating microorganism, is one of the most significant problems in the cell-culture field. It characterized by the absence of the cell wall, causing resistance to commonly used antibiotics ...
Characterization Of Genomic Alterations And Tcrβ Repertoire Of Tumor- Infiltrating Lymphocytes In Breast Cancer
(Biomedical Sciences, 2018 , Master Thesis)
Breast cancer still remains a major cause of morbidity and mortality among
women in Qatar and worldwide. More recent studies indicate that the diversity and
the composition of the entire set of antigen receptors within ...
Molecular Analysis Of The Brca1 And Brca2 Genes In Hereditary Breast Or Ovarian Cancer Patients In Qatar (2015-2016)
(Biomedical Sciences, 2018 , Master Thesis)
The frequency of BRCA1 and BRCA2 mutations is understudied in Arab women
and there are no studies investigating BRCA1/2 mutations in Qatar. In this study, we
sequenced BRCA1 and BRCA2 genes in 183 patients suspected of ...
The Expression of Retinal miRNA Evoked by Hyperglycemia and After Adiponectin Treatment in Human Retinal Endothelial Cells
(Biomedical Sciences, 2018 , Master Thesis)
Background: Diabetes mellitus is a chronic metabolic disease resulting in microvascular complications including diabetic retinopathy (DR). Adiponectin (ApN) is an adipokine hormone, and recent studies demonstrated that ApN ...
Profiling of Chronic Myeloid Neoplasms through RNA Sequencing Analysis
(Biomedical Sciences, 2018 , Master Thesis)
Background: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder resulting from the neoplastic transformation of hematopoietic stem cells. A higher number of (54%) CML patients in Qatar failed to respond ...