Show simple item record

AuthorAlateyah, Nouralhuda
AuthorAlsafran, Mohammed
AuthorUsman, Kamal
AuthorOuhtit, Allal
Available date2023-10-10T07:35:59Z
Publication Date2023-10-07
Publication NameNutrients
Identifierhttp://dx.doi.org/10.3390/nu15194276
CitationAlateyah, N.; Alsafran, M.; Usman, K.; Ouhtit, A. Molecular Evidence of Breast Cancer Cell Proliferation Inhibition by a Combination of Selected Qatari Medicinal Plants Crude Extracts. Nutrients 2023, 15, 4276. https://doi.org/10.3390/nu15194276
URIhttp://hdl.handle.net/10576/48390
Abstract: Breast cancer (BC) is the most common malignancy, and conventional medicine has failed to establish efficient treatment modalities. Conventional medicine failed due to lack of knowledge of the mechanisms that underpin the onset and metastasis of tumors, as well as resistance to treatment regimen. However, Complementary and Alternative medicine (CAM) modalities are currently drawing the attention of both the public and health professionals. Our study examined the effect of a super-combination (SC) of crude extracts, which were isolated from three selected Qatari medicinal plants, on the proliferation, motility and death of BC cells. Our results revealed that SC attenuated cell growth and caused the cell death of MDA-MB-231 cancer cells when compared to human normal neonatal fibroblast cells. On the other hand, functional assays showed that SC reduced BC cell migration and invasion, respectively. SC-inhibited cell cycle and SC-regulated apoptosis was most likely mediated by p53/p21 pathway and p53-regulated Bax/BCL-2/Caspace-3 pathway. Our ongoing experiments aim to validate these in vitro findings in vivo using a BC-Xenograft mouse model. These findings support our hypothesis that SC inhibited BC cell proliferation and induced apoptosis. These findings lay the foundation for further experiments, aiming to validate SC as an effective chemoprevention and/or chemotherapeutic strategy that can ultimately pave the way towards translational research/clinical trials for the eradication of BC.
SponsorThis research was made possible by support from the Qatar University’s-Japan Research Collaboration Grant (M-QJRC-2020-10) and the Qatar National Research Fund (UREP21-080-1-015 and UREP29-186-3-059).
Languageen
PublisherMDPI
Subjectbreast tumors
cell growth and cell survival
cell death
cell motility and invasion
TitleMolecular Evidence of Breast Cancer Cell Proliferation Inhibition by a Combination of Selected Qatari Medicinal Plants Crude Extracts
TypeArticle
Issue Number19
Volume Number15
ESSN2072-6643
dc.accessType Open Access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record